公开(公告)号：EP2914276A2

公开(公告)日：2015-09-09

申请号：EP13850219.0

申请日：2013-10-31

申请人： IPSEN PHARMA S.A.S.

发明人： DONG, Zheng, Xin ,  FERRANDIS, Eric

IPC分类号： A61K38/00

CPC分类号： C07K7/64 ,  A61K38/12 ,  G01N33/74 ,  G01N2333/726

摘要： The present invention relates to novel somatostatin analogs, dimers thereof, and methods of using the same to treat various diseases. Naturally occurring somatostatins (SSTs), which are also known as somatotropin release-inhibiting factors (SRIFs), have diverse biological effects in many cells and organs 10 throughout the body. They are produced by normal endocrine, gastrointestinal, immune and neuronal cells, as well as by certain tumors (Patel, Y. C, Frontiers in Neuroendocrinology, 20(3): 157-198 (1999); Froidevaux, et al., Biopolymers, 66(3): 161-83 (2002)).

摘要翻译： 本发明涉及新型促生长素抑制素类似物，其二聚体，及其用于治疗各种疾病的方法。 自然发生的生长激素抑制因子（SSTs）也称为生长激素释放抑制因子（SRIF），在整个身体的许多细胞和器官10中具有多种生物学作用。 它们由正常的内分泌，胃肠道，免疫和神经元细胞以及某些肿瘤产生（Patel，Y.C，Frontiers in Neuroendocrinology，20（3）：157-198（1999）; Froidevaux等人，Biopolymers ，66（3）：161-83（2002））。

公开(公告)号：EP2102162A1

公开(公告)日：2009-09-23

申请号：EP07866449.7

申请日：2007-10-26

申请人： IPSEN PHARMA S.A.S.

发明人： POITOUT, Lydie ,  HARNETT, Jeremiah ,  BIGG, Dennis ,  SACKUR, Carole ,  FERRANDIS, Eric

IPC分类号： C07D215/48 ,  C07D263/32 ,  C07D271/06 ,  C07D271/10 ,  C07D285/12 ,  C07D311/80 ,  C07D413/12 ,  C07C233/00 ,  A61K31/4245 ,  A61K31/433 ,  A61K31/47 ,  A61P37/00

CPC分类号： C07D271/107 ,  C07D215/48 ,  C07D263/32 ,  C07D271/06 ,  C07D285/12 ,  C07D311/80 ,  C07D413/12

摘要： The present invention relates to new phenylic derivatives, wherein these products exhibit a good affinity for certain sub-types of cannabinoid receptors, in particular the CB2 receptors. They are of particular interest for treating pathological conditions and diseases in which one or more cannabinoid receptors are involved. The invention also relates to pharmaceutical compositions containing said products, and to the use thereof for the preparation of a drug.