专利检索 ap:("IRM, LLC") AND inv:"CHO, Charles" 第 1 页

1.

发明公开
METHODS AND COMPOSITION FOR MODULATING FOXO1 ACTIVITY AND INSULIN SIGNALING 审中-公开
标题翻译：方法和组合物调制FOXO1活动与胰岛素信号

公开(公告)号：EP1907016A2

公开(公告)日：2008-04-09

申请号：EP06787013.9

申请日：2006-07-11

申请人： IRM, LLC

发明人： CHO, Charles , CHANDA, Sumit , SCHULTZ, Peter G.

IPC分类号： A61K48/00 , C12N15/11

CPC分类号： C07K14/4702 , A61K48/00 , C12N15/1137 , C12N2310/111 , C12N2310/14 , C12N2310/53 , C12Y301/03048

摘要： The invention provides methods for modulating insulin signaling pathway and methods for treating insulin resistance. The methods employ agents which modulate FOXO1 subcellular localization. The invention also provides methods of screening for compounds that modulate insulin signaling related activities such as gluconeogenesis and cell proliferation.