公开(公告)号：EP1725686A4

公开(公告)日：2008-12-10

申请号：EP05856582

申请日：2005-02-18

申请人： ISIS PHARMACEUTICALS INC

发明人： MASSIRE CHRISTIAN ,  ESHOO MARK W ,  ECKER DAVID J ,  HALL THOMAS A ,  SAMPATH RANGARAJAN

IPC分类号： C12Q1/68 ,  C07H21/02

CPC分类号： C12Q1/689

摘要： The present invention provides oligonucleotide primers and compositions and kits containing the same for rapid identification of bacteria by amplification of a segment of bacterial nucleic acid followed by molecular mass analysis.

公开(公告)号：EP1623013A4

公开(公告)日：2008-08-27

申请号：EP04775904

申请日：2004-04-23

申请人： ISIS PHARMACEUTICALS INC

发明人： ECKER DAVID J ,  HOFSTADLER STEVEN A ,  SAMPATH RANGARAJAN ,  BLYN LAWRENCE B ,  HALL THOMAS A ,  MASSIRE CHRISTIAN

IPC分类号： C12N15/00 ,  C12N20060101 ,  C12Q1/68 ,  C12Q1/70

CPC分类号： C12Q1/701 ,  C12N2770/20011 ,  Y10T436/24

摘要： The present invention provides a method for rapid identification and quantitation of bacteria by amplification of a segment of bacterial nucleic acid followed by analysis by mass spectrometry. The compositions provide for characterization of the molecular masses and base compositions of bacterial nucleic acids which are used to rapidly identify bacteria.

公开(公告)号：EP1573065A4

公开(公告)日：2007-08-08

申请号：EP03810055

申请日：2003-12-05

申请人： ISIS PHARMACEUTICALS INC

发明人： ECKER DAVID J ,  CROOKE STANLEY T ,  BLYN LAWRENCE B ,  HALL THOMAS A ,  JIANG YUN ,  GRIFFEY RICHARD H ,  SAMPATH RANGARAJAN ,  HOFSTADLER STEVEN A ,  MCNEIL JOHN ,  HANNIS JAMES C ,  WHITE NEIL ,  SAMANT VIVEK ,  ESHOO MARK W ,  DRADER JARED J

IPC分类号： C07H21/04 ,  C12P19/34 ,  C12Q20060101 ,  C12Q1/68 ,  C12Q1/70

CPC分类号： C12Q1/686 ,  C12Q1/6806 ,  C12Q1/6844 ,  C12Q1/6858 ,  C12Q1/6872 ,  C12Q1/6888 ,  C12Q1/689 ,  C12Q2600/156 ,  G01N2333/28 ,  G01N2333/32 ,  G01N2333/35 ,  G01N2333/36 ,  C12Q2563/167 ,  C12Q2545/101 ,  C12Q2531/113 ,  C12Q2565/627 ,  C12Q2545/113

摘要： The present invention provides methods for rapid forensic analysis of mitochondrial DNA and methods for characterizing heteroplasmy of mitochondrial DNA, which can be used to assess the progression of mitochondrial diseases.

摘要翻译： 本发明提供线粒体DNA快速法医分析方法和线粒体DNA异质性表征方法，可用于评估线粒体疾病的进展。

公开(公告)号：EP1578399A4

公开(公告)日：2007-11-28

申请号：EP03814656

申请日：2003-12-05

申请人： ISIS PHARMACEUTICALS INC

发明人： ECKER DAVID J ,  GRIFFEY RICHARD H ,  SAMPATH RANGARAJAN ,  HOFSTADLER STEVEN A ,  MCNEIL JOHN ,  CROOKE STANLEY T ,  BLYN LAWRENCE B ,  RANKEN RAYMOND ,  HALL THOMAS A

IPC分类号： A61K20060101 ,  A61K9/00 ,  C07H21/00 ,  C12Q1/68 ,  C12Q1/70 ,  C07H21/02 ,  C12P19/34

CPC分类号： C12Q1/689 ,  C12Q1/6872 ,  C12Q1/70 ,  C12Q1/701 ,  C12Q2600/16 ,  G01N1/30 ,  G01N21/64 ,  G01N23/00 ,  G06F19/20

摘要： The present invention provides methods of: identifying pathogens in biological samples from humans and animals, resolving a plurality of etiologic agents present in samples obtained from humans and animals, determining detailed genetic information about such pathogens or etiologic agents, and rapid detection and identification of bioagents from environmental, clinical or other samples.