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1.发明公开METHODS FOR RAPID FORENSIC ANALYSIS OF MITOCHONDRIAL DNA AND CHARACTERIZATIONG OF MITOCHONDRIAL DNA HETEROPLASMY 有权VERFAHREN ZUR SCHNELLEN FORENSISCHENANALYSE MITOCHONDRIALER DNA UND CHARAKTERISIERUNG DER HETEROPLASMIEMITOCHONDRIALER DNA
公开(公告)号：EP1573065A4
公开(公告)日：2007-08-08
申请号：EP03810055
申请日：2003-12-05
发明人： ECKER DAVID J , CROOKE STANLEY T , BLYN LAWRENCE B , HALL THOMAS A , JIANG YUN , GRIFFEY RICHARD H , SAMPATH RANGARAJAN , HOFSTADLER STEVEN A , MCNEIL JOHN , HANNIS JAMES C , WHITE NEIL , SAMANT VIVEK , ESHOO MARK W , DRADER JARED J
IPC分类号： C07H21/04 , C12P19/34 , C12Q20060101 , C12Q1/68 , C12Q1/70
CPC分类号： C12Q1/686 , C12Q1/6806 , C12Q1/6844 , C12Q1/6858 , C12Q1/6872 , C12Q1/6888 , C12Q1/689 , C12Q2600/156 , G01N2333/28 , G01N2333/32 , G01N2333/35 , G01N2333/36 , C12Q2563/167 , C12Q2545/101 , C12Q2531/113 , C12Q2565/627 , C12Q2545/113
摘要： The present invention provides methods for rapid forensic analysis of mitochondrial DNA and methods for characterizing heteroplasmy of mitochondrial DNA, which can be used to assess the progression of mitochondrial diseases.
摘要翻译： 本发明提供线粒体DNA快速法医分析方法和线粒体DNA异质性表征方法，可用于评估线粒体疾病的进展。
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2.发明公开IDENTIFICATION OF MOLECULAR INTERACTION SITES IN RNA FOR NOVEL DRUG DISCOVERY 审中-公开在RNA分子间的相互作用点的DISCOVERY新药鉴定
公开(公告)号：EP1082462A4
公开(公告)日：2003-07-09
申请号：EP99922938
申请日：1999-05-12
发明人： ECKER DAVID J , SAMPATH RANGA , GRIFFEY RICHARD , MCNEIL JOHN
IPC分类号： C12N15/09 , A61K31/7105 , A61K31/713 , A61K48/00 , A61P31/04 , C07H21/02 , C07H21/04 , C12N15/11 , C12Q1/68
CPC分类号： C12Q1/6876
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公开(公告)号：EP1364064A4
公开(公告)日：2005-11-23
申请号：EP02709785
申请日：2002-03-04
IPC分类号： G01N27/62 , C12N15/09 , C12Q1/68 , C07H21/02 , C07K5/00 , C12P19/34 , C12Q1/70 , G01N33/53 , G01N33/566
CPC分类号： C12Q1/689 , C12Q1/686 , C12Q2600/156 , C12Q2565/627
摘要： Method for detecting and identifying unknown bioagents, including bacteria, viruses and the like, by a combination of nucleic acid amplification and molecular weight determination using primers which hybridize to conserved sequence regions of nucleic acids derived from a bioagent and which bracket variable sequence regions that uniquely identify the bioagent. The result is a 'base composition signature' (BCS) which is then matched against a database of base composition signatures, by which the bioagent is identified.
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4.发明公开
公开(公告)号：EP1083980A4
公开(公告)日：2004-01-07
申请号：EP99924185
申请日：1999-05-12
发明人： ECKER DAVID J , GRIFFEY RICHARD , CROOKE STANELY T , SAMPATH RANGA , SWAYZE ERIC , MOHAN VENKATRAMAN , HOFSTADLER STEVEN , MCNEIL JOHN
IPC分类号： G01N31/00 , A61K45/00 , A61P43/00 , B01J19/00 , C07B61/00 , C07K1/04 , C12N15/10 , C12N15/113 , C12P19/30 , C12Q1/68 , C40B20/00 , C40B30/00 , C40B30/02 , C40B40/02 , C40B50/02 , C40B50/06 , C40B60/14 , G01N33/53 , G01N33/566 , G01N33/68 , G06F17/30 , G06F17/50 , C12N15/11 , C12P19/34 , G01N33/543 , G06F15/18
CPC分类号： G01N33/6848 , B01J19/0046 , B01J2219/00286 , B01J2219/00308 , B01J2219/00313 , B01J2219/00351 , B01J2219/00585 , B01J2219/0059 , B01J2219/00659 , B01J2219/00689 , B01J2219/00695 , B01J2219/007 , B01J2219/0072 , C07K1/047 , C12N15/1048 , C12N15/113 , C12Q1/6811 , C40B60/14 , G01N33/68 , G01N33/6851
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5.发明公开
公开(公告)号：EP1578399A4
公开(公告)日：2007-11-28
申请号：EP03814656
申请日：2003-12-05
发明人： ECKER DAVID J , GRIFFEY RICHARD H , SAMPATH RANGARAJAN , HOFSTADLER STEVEN A , MCNEIL JOHN , CROOKE STANLEY T , BLYN LAWRENCE B , RANKEN RAYMOND , HALL THOMAS A
CPC分类号： C12Q1/689 , C12Q1/6872 , C12Q1/70 , C12Q1/701 , C12Q2600/16 , G01N1/30 , G01N21/64 , G01N23/00 , G06F19/20
摘要： The present invention provides methods of: identifying pathogens in biological samples from humans and animals, resolving a plurality of etiologic agents present in samples obtained from humans and animals, determining detailed genetic information about such pathogens or etiologic agents, and rapid detection and identification of bioagents from environmental, clinical or other samples.
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公开(公告)号：EP1581657A4
公开(公告)日：2007-09-12
申请号：EP03796752
申请日：2003-12-05
发明人： ECKER DAVID J , GRIFFEY RICHARD H , HOFSTADLER STEVEN A , SAMPATH RANGARAJAN , MCNEIL JOHN , CROOKE STANLEY T
CPC分类号： C12Q1/689 , C12Q1/686 , Y10T436/24 , C12Q2565/627
摘要： The present invention provides methods of: identifying pathogens in biological samples from humans and animals, resolving a plurality of etiologic agents present in samples obtained from humans and animals, determining detailed genetic information about such as pathogens or etiologic agents, and rapid detection and identification of bioagents from environmental, clinical or other samples.
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7.发明公开IDENTIFICATION OF GENETIC TARGETS FOR MODULATION BY OLIGONUCLEOTIDES AND GENERATION OF OLIGONUCLEOTIDES FOR GENE MODULATION 有权调制基因靶向由调制基因的寡核苷酸及其生产OLIGONUCLEOTIDES鉴定
公开(公告)号：EP1071826A4
公开(公告)日：2003-05-21
申请号：EP99922713
申请日：1999-04-13
发明人： COWSERT LEX M , BAKER BRENDA F , MCNEIL JOHN , FREIER SUSAN M , SASMOR HENRI M , BROOKS DOUGLAS G , OHASHI CARA , WYATT JACQUELINE R , BORCHERS ALEXANDER H , VICKERS TIMOTHY A
IPC分类号： C12N15/09 , C07B61/00 , C12N15/10 , C12Q1/68 , C40B30/02 , C40B40/02 , C40B50/02 , C40B50/06 , G06F17/30 , G06F17/50 , G06F19/18 , G06F19/22 , C12N15/11 , G06F19/00
CPC分类号： G06F19/18 , B01J2219/007 , C40B50/02 , G06F19/22
摘要： Iterative, preferably computer based iterative processes for generating synthetic compounds with desired physical, chemical and/or bioactive properties, i.e., active compounds, are provided. During iterations of the processes, a target nucleic acid sequence is provided or selected, and a library of candidate nucleobase sequences is generated in silico according to defined criteria. A 'virtual' oligonucleotide chemistry is chosen and a library of virtual oligonucleotide compounds having the selected nucleobase sequences is generated. These virtual compounds are reviewed and compounds predicted to have particular properties are selected. The selected compounds are robotically synthesized and are preferably robotically assayed for a desired physical, chemical or biological activity. Active compounds are thus generated and, at the same time, preferred sequences and regions of the target nucleic acid that are amenable to oligonucleotide or sequence-based modulation are identified.
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