公开(公告)号：EP2475675A4

公开(公告)日：2013-05-15

申请号：EP10816206

申请日：2010-09-10

申请人： ISIS PHARMACEUTICALS INC

发明人： HUNG GENE ,  BENNETT C FRANK ,  FREIER SUSAN M ,  KORDASIEWICZ HOLLY ,  STANEK LISA ,  CLEVELAND DON W ,  CHENG SENG H ,  SHIHABUDDIN LAMYA

IPC分类号： C12N15/113 ,  A61K31/712 ,  A61K31/7125

CPC分类号： C12N15/113 ,  C12N2310/11 ,  C12N2310/113 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/345 ,  C12N2310/346 ,  C12N2310/3525

摘要： Provided herein are methods, compounds, and compositions for reducing expression of huntingtin mRNA and protein in an animal. Such methods, compounds, and compositions are useful to treat, prevent, delay, or ameliorate Huntington's disease, or a symptom thereof.