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1.发明公开OLIGOMERIC COMPOUNDS COMPRISING BICYCLIC NUCLEOTIDES AND USES THEREOF 有权维生素DVON OLIGOMERE VERBINDUNGEN MIT BICYCLISCHEN NUKLEOTIDEN
公开(公告)号：EP2839006A4
公开(公告)日：2015-12-16
申请号：EP13777683
申请日：2013-04-22
发明人： FREIER SUSAN M , SWAYZE ERIC E
IPC分类号： C12N15/113 , C12N15/11
CPC分类号： C12N15/113 , C12N15/111 , C12N15/1137 , C12N2310/11 , C12N2310/321 , C12N2310/3231 , C12N2310/341 , C12N2310/343 , C12N2310/3525 , C12N2320/51 , C12Y301/03016 , C12Y301/03048 , C12Y301/03067
摘要： The present invention provides oligomeric compounds. Certain such oligomeric compounds are useful for hybridizing to a complementary nucleic acid, including but not limited, to nucleic acids in a cell. In certain embodiments, hybridization results in modulation of the amount activity or expression of the target nucleic acid in a cell.
摘要翻译： 本发明提供低聚化合物。 某些这样的寡聚化合物可用于与互补核酸杂交，包括但不限于细胞中的核酸。 在某些实施方案中，杂交导致调节细胞中靶核酸的量活性或表达。
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公开(公告)号：EP2771463A4
公开(公告)日：2015-09-09
申请号：EP12843053
申请日：2012-10-25
发明人： FREIER SUSAN M , BHANOT SANJAY
CPC分类号： C12N15/1138 , A61K31/7088 , A61K31/7115 , A61K31/712 , A61K31/7125 , A61K45/06 , C07H21/04 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/3231 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525 , C12N2310/3521
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公开(公告)号：EP2699583A4
公开(公告)日：2015-04-15
申请号：EP12773736
申请日：2012-04-20
发明人： SWAYZE ERIC E , FREIER SUSAN M , MCCALEB MICHAEL L
IPC分类号： C07H21/02
CPC分类号： C12N15/1131 , C12N2310/11 , C12N2310/313 , C12N2310/315 , C12N2310/321 , C12N2310/3231 , C12N2310/3341 , C12N2310/341 , C12N2310/344 , C12N2310/346 , C12N2320/30 , C12N2310/3525
摘要： Disclosed herein are antisense compounds and methods for decreasing HBV mRNA, DNA and protein expression. Such methods, compounds, and compositions are useful to treat, prevent, or ameliorate HBV-related diseases, disorders or conditions.
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4.发明公开MODULATION OF SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3 (STAT3) EXPRESSION 审中-公开调制信号信号接收器发现信号转换3（STAT3） - 表达式
公开(公告)号：EP2697243A4
公开(公告)日：2015-04-01
申请号：EP12763390
申请日：2012-03-30
发明人： SWAYZE ERIC E , FREIER SUSAN M , MACLEOD ROBERT A , KIM YOUNGSOO
CPC分类号： C12N15/113 , C07H21/00 , C07H21/04 , C12N15/00 , C12N15/11 , C12N15/1135 , C12N2310/11 , C12N2310/315 , C12N2310/3231 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2320/30 , C12N2310/321 , C12N2310/3521 , C12N2310/3525
摘要： Disclosed herein are antisense compounds and methods for decreasing STAT3 mRNA and protein expression. Such methods, compounds, and compositions are useful to treat, prevent, or ameliorate hyperproliferative diseases.
摘要翻译： 本文公开了用于降低STAT3 mRNA和蛋白质表达的反义化合物和方法。 这些方法，化合物和组合物可用于治疗，预防或改善过度增殖性疾病。
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公开(公告)号：EP2475675A4
公开(公告)日：2013-05-15
申请号：EP10816206
申请日：2010-09-10
发明人： HUNG GENE , BENNETT C FRANK , FREIER SUSAN M , KORDASIEWICZ HOLLY , STANEK LISA , CLEVELAND DON W , CHENG SENG H , SHIHABUDDIN LAMYA
IPC分类号： C12N15/113 , A61K31/712 , A61K31/7125
CPC分类号： C12N15/113 , C12N2310/11 , C12N2310/113 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/345 , C12N2310/346 , C12N2310/3525
摘要： Provided herein are methods, compounds, and compositions for reducing expression of huntingtin mRNA and protein in an animal. Such methods, compounds, and compositions are useful to treat, prevent, delay, or ameliorate Huntington's disease, or a symptom thereof.
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6.发明公开ANTISENSE OLIGONUCLEOTIDES DIRECTED AGAINST CONNECTIVE TISSUE GROWTH FACTOR AND USES THEREOF 有权AGAINST THE结缔组织生长因子的前瞻性反义寡核苷酸及其用途
公开(公告)号：EP2331141A4
公开(公告)日：2013-01-23
申请号：EP09819622
申请日：2009-08-25
IPC分类号： C12N15/113 , A61K31/7088 , A61K48/00
CPC分类号： C12N15/1136 , C12N15/113 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/3231 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2320/30 , C12N2310/3521
摘要： This invention provides compounds which comprise modified oligonucleotides capable of inhibitory expression of connective tissue factor and composition containing same as well as methods of treating hyperprolific disorders and fibrotic diseases, and of reducing scarring resulting from wound healing using such compounds.
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公开(公告)号：EP1570082A4
公开(公告)日：2006-04-26
申请号：EP03789949
申请日：2003-11-21
发明人： FREIER SUSAN M , DOBIE KENNETH W
CPC分类号： C12N15/1138 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the expression of Notch2. The compositions comprise oligonucleotides, targeted to nucleic acid encoding Notch2. Methods of using these compounds for modulation of Notch2 expression and for diagnosis and treatment of disease associated with expression of Notch2 are provided.
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8.发明公开ANTISENSE INHIBITION OF ras GENE WITH CHIMERIC AND ALTERNATING OLIGONUCLEOTIDES 失效ras基因嵌合BY交替寡核苷酸反义抑制
公开(公告)号：EP0981648A4
公开(公告)日：2002-05-22
申请号：EP98923319
申请日：1998-04-30
IPC分类号： C12N15/09 , A61K31/7125 , A61K48/00 , A61P35/00 , C07H21/00 , C07H21/02 , C07H21/04 , C12N15/113 , C12Q1/68 , C07H19/06 , C07H19/067 , C07H19/09 , C07H19/16 , C07H19/167 , C07H19/173 , C12P19/34
CPC分类号： C12N15/1135 , C07H21/00 , C12N2310/315 , C12N2310/318 , C12N2310/321 , C12N2310/322 , C12N2310/341 , C12N2310/345 , C12N2310/346 , C12Q1/6876 , C12Q2600/158 , C12N2310/3525
摘要： Compositions and methods are provided for the modulation of expression of the human ras gene in both the normal and activated forms. Oligonucleotides are provided that have methylene(methylimino) linkages alternating with phosphorothioate or phosphodiester linkages. Further oligonucleotides are provided that have a first region having a methylene(methylimino) linkage alternating with a phosphorothioate or phosphodiester linkage and a second region having phosphorothioate linkages. Such oligonucleotides can be used for diagnostics as well as for research purposes including methods for diagnosis, detection and treatment of conditions arising from the activation of the H-ras gene.
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公开(公告)号：EP2640853A4
公开(公告)日：2015-01-07
申请号：EP11840796
申请日：2011-11-17
IPC分类号： C12Q1/68 , A61K48/00 , C07H21/04 , C12N15/113
CPC分类号： C12N15/113 , C12N2310/11 , C12N2310/315 , C12N2310/323 , C12N2310/3231 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/321 , C12N2310/3525
摘要： Disclosed herein are antisense compounds and methods for decreasing alpha-synuclein mRNA and protein expression. Also disclosed herein are methods for treating, preventing, and ameliorating neurodegenerative diseases in an individual in need thereof.
摘要翻译： 本文公开了用于降低α-突触核蛋白mRNA和蛋白质表达的反义化合物和方法。 本文还公开了在有需要的个体中治疗，预防和改善神经变性疾病的方法。
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公开(公告)号：EP2697244A4
公开(公告)日：2014-12-10
申请号：EP12771485
申请日：2012-04-13
发明人： BHANOT SANJAY , FREIER SUSAN M
IPC分类号： C07H21/04 , C12N15/113
CPC分类号： C12N15/1137 , A61K31/7088 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/3231 , C12N2310/3341 , C12N2310/34 , C12N2310/341 , C12N2310/346 , C12N2320/30 , C12Y301/03048 , C12N2310/3525
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