公开(公告)号：EP0711286A1

公开(公告)日：1996-05-15

申请号：EP94924778.0

申请日：1994-07-18

申请人： ITALFARMACO S.p.A.

发明人： LEVI, Silvio ,  BENEDINI, Francesca ,  BERTOLINI, Giorgio ,  GROMO, Gianni ,  MIZRHAI, Jacques ,  SALA, Alberto

IPC分类号： A61K31 ,  A61P9 ,  C07D265 ,  C07D279 ,  C07D417

CPC分类号： C07D265/22 ,  C07D279/08

摘要： Compounds of general formula (I) wherein X is an oxygen or sulfur atom; Y is alkylene or cycloalkylene; A is hydroxy, alkoxy, acyloxy, mercapto, alkyl-sulfonyloxy, phenyl-sulfonyloxy, (a) or (b) wherein R3 is an alkyl or alkylene group φ-substituted by 2,3-dihydro-4H-1,3-benzoxazin-4-one-N-yl; R is hydrogen, alkyl or phenyl; R1 and R2 are independently hydrogen, halogen, alkoxy, trifluoromethyl or alkyl; and the pharmaceutically acceptable acid and base salts thereof, are useful as therapeutically active substances.

公开(公告)号：EP0748310A1

公开(公告)日：1996-12-18

申请号：EP95910509.0

申请日：1995-02-22

申请人： ITALFARMACO S.p.A.

发明人： SALA, Alberto ,  BERTOLINI, Giorgio ,  PAVICH, Gianfranco ,  MARUCCI, Fabrizio ,  GROMO, Gianni ,  PORRO, Giuliana

IPC分类号： A61K31 ,  A61P29 ,  A61P31 ,  A61P37 ,  C07C219 ,  C07D207 ,  C07D211 ,  C07D213 ,  C07D295

CPC分类号： C07D207/08 ,  C07C219/16 ,  C07C219/22 ,  C07C219/24 ,  C07C219/32 ,  C07C2601/14 ,  C07D211/22 ,  C07D295/088

摘要： Diesters of carbonic acid disubstituted with primary, secondary or tertiary amine groups, pharmaceutically acceptable salts thereof, and their use as antiviral and anti-inflammatory agents.

摘要翻译： 用伯，仲或叔胺基团二取代的碳酸二酯，其药学上可接受的盐，以及它们作为抗病毒和炎症介质的用途。

公开(公告)号：EP0901465B1

公开(公告)日：2000-09-27

申请号：EP97923053.9

申请日：1997-05-12

申请人： ITALFARMACO S.p.A.

发明人： BERTOLINI, Giorgio ,  BIFFI, Mauro ,  LEONI, Flavio ,  MIZRAHI, Jacques ,  PAVICH, Gianfranco ,  MASCAGNI, Paolo

IPC分类号： C07C259/10 ,  C07C259/08 ,  C07C243/38 ,  C07C243/24

CPC分类号： C07C259/10 ,  C07C275/42 ,  C07C2602/10 ,  C07C2603/18 ,  C07C2603/74 ,  C07D217/16

摘要： Compounds of formula (I), wherein R' is hydrogen or alkyl; A is adamantyl or a mono-, bi- or tricyclic residue optionally unsaturated, a heterocyclic residue and/or substituted by hydroxy, alkanoyloxy, amino, aminoalkyl, halogen, alkyl, trialkylammoniumalkyl; (a) is a chain of 1 to 5 carbon atoms optionally containing a double bond or a NR'; R is hydrogen or phenyl; X is O or NR' or is absent; r and m are independently 0, 1 or 2; B is phenylene or cyclohexylene; Y is hydroxy or aminoalkyl optionally interrupted by an O; have anti-inflammatory and immunosuppressive activities.

公开(公告)号：EP0748310B1

公开(公告)日：1999-06-02

申请号：EP95910509.9

申请日：1995-02-22

申请人： ITALFARMACO S.p.A.

发明人： SALA, Alberto ,  BERTOLINI, Giorgio ,  PAVICH, Gianfranco ,  MARCUCCI, Fabrizio ,  GROMO, Gianni ,  PORRO, Giuliana

IPC分类号： C07C219/16 ,  A61K31/265 ,  A61K31/44 ,  C07D213/30 ,  C07D211/22 ,  C07D295/08 ,  C07D207/08 ,  C07C219/32 ,  C07C219/22

CPC分类号： C07D207/08 ,  C07C219/16 ,  C07C219/22 ,  C07C219/24 ,  C07C219/32 ,  C07C2601/14 ,  C07D211/22 ,  C07D295/088

公开(公告)号：EP0901465A1

公开(公告)日：1999-03-17

申请号：EP97923053.0

申请日：1997-05-12

申请人： ITALFARMACO S.p.A.

发明人： BERTOLINI, Giorgio ,  BIFFI, Mauro ,  LEONI, Flavio ,  MIZRAHI, Jacques ,  PAVICH, Gianfranco ,  MASCAGNI, Paolo

IPC分类号： C07D217 ,  A61K31 ,  A61P29 ,  A61P37 ,  C07C243 ,  C07C259 ,  C07C275

CPC分类号： C07C259/10 ,  C07C275/42 ,  C07C2602/10 ,  C07C2603/18 ,  C07C2603/74 ,  C07D217/16

摘要： Compounds of formula (I), wherein R' is hydrogen or alkyl; A is adamantyl or a mono-, bi- or tricyclic residue optionally unsaturated, a heterocyclic residue and/or substituted by hydroxy, alkanoyloxy, amino, aminoalkyl, halogen, alkyl, trialkylammoniumalkyl; (a) is a chain of 1 to 5 carbon atoms optionally containing a double bond or a NR'; R is hydrogen or phenyl; X is O or NR' or is absent; r and m are independently 0, 1 or 2; B is phenylene or cyclohexylene; Y is hydroxy or aminoalkyl optionally interrupted by an O; have anti-inflammatory and immunosuppressive activities.

摘要翻译： 式（I）的酰胺化合物是新的。 R'= H或1-4C烷基; A =金刚烷基或单环，双环或三环的任选部分或完全不饱和的，其可以含有一个或多个选自N，S和O的杂原子，并且任选被OH，烷酰氧基，伯，仲或叔氨基取代， 1-4C氨基烷基，一或二（1-4C烷基）氨基（1-4C烷基）卤素，1-4C烷基或ti（1-4C烷基）铵（1-4C烷基）; Z =任选含有双键或NR'基团的1-5C碳链; R = H或苯基; X = O或NR'或不存在; r，m = 0-2; B =亚苯基或亚环己基; Y = OH或任选被O中断的氨基（1-4C烷基） 条件是只有当相同的X不为O且Y不为OH时，A为芴基，除非芴基被三（1-4C烷基）铵（1-4C烷基）基团取代。