公开(公告)号：EP2968525A1

公开(公告)日：2016-01-20

申请号：EP14774247.2

申请日：2014-03-04

申请人： Icahn School of Medicine at Mount Sinai ,  Memorial Sloan Kettering Cancer Center

发明人： PALESE, Peter ,  GARCIA-SASTRE, Adolfo ,  ZAMARIN, Dmitriy ,  ALLISON, James ,  WOLCHOK, Jedd, D.

IPC分类号： A61K39/17 ,  A61P35/00 ,  C12N15/09

CPC分类号： A61K35/768 ,  A61K39/3955 ,  A61K2039/505 ,  C07K16/2818 ,  C07K16/2827 ,  C07K16/2878 ,  C07K2317/76 ,  C12N7/00 ,  C12N2760/18121 ,  C12N2760/18122 ,  C12N2760/18132 ,  C12N2760/18133 ,  C12N2760/18143

摘要： Described herein are chimeric Newcastle disease viruses engineered to express an agonist of a co-stimulatory signal of an immune cell and compositions comprising such viruses. Also described herein are chimeric Newcastle disease viruses engineered to express an antagonist of an inhibitory signal of an immune cell and compositions comprising such viruses. The chimeric Newcastle disease viruses and compositions are useful in the treatment of cancer. In addition, described herein are methods for treating cancer comprising administering Newcastle disease viruses in combination with an agonist of a co-stimulatory signal of an immune and/or an antagonist of an inhibitory signal of an immune cell.

公开(公告)号：EP2482849B1

公开(公告)日：2018-06-06

申请号：EP10821297.8

申请日：2010-09-30

申请人： Memorial Sloan-Kettering Cancer Center ,  Board of Regents, The University of Texas System

发明人： ALLISON, James ,  SHARMA, Padmanee ,  QUEZADA, Sergio, A. ,  FU, Tihui

IPC分类号： A61K39/395 ,  A61P35/00 ,  C07K16/28

CPC分类号： C07K16/2818 ,  A61K38/1709 ,  A61K39/3955 ,  A61K39/39558 ,  A61K2039/505 ,  A61K2039/507 ,  C07K16/2803 ,  C07K16/2827 ,  C07K2317/73 ,  C07K2317/74 ,  C07K2317/75 ,  C07K2317/76 ,  A61K2300/00

摘要： Agonists to ICOS in combination with a blocking agent to a T cell inhibitory receptor (e.g., CTLA-4, PD-I, etc.) are demonstrated herein to be useful for the treatment of tumors.

公开(公告)号：EP3375791A1

公开(公告)日：2018-09-19

申请号：EP18169332.6

申请日：2010-09-30

申请人： Memorial Sloan Kettering Cancer Center ,  Board of Regents, The University of Texas System

发明人： ALLISON, James ,  SHARMA, Padmanee ,  QUEZADA, Sergio, A. ,  FU, Tihui

IPC分类号： C07K16/28 ,  A61K39/395 ,  A61P35/00

CPC分类号： C07K16/2818 ,  A61K38/1709 ,  A61K39/3955 ,  A61K39/39558 ,  A61K2039/505 ,  A61K2039/507 ,  C07K16/2803 ,  C07K16/2827 ,  C07K2317/73 ,  C07K2317/74 ,  C07K2317/75 ,  C07K2317/76 ,  A61K2300/00

摘要： The present invention provides agonists to ICOS in combination with a blocking agent to a T cell inhibitory receptor (e.g., CTLA-4, PD-1, etc.) are demonstrated herein to be useful for the treatment of tumors.

公开(公告)号：EP2482849A2

公开(公告)日：2012-08-08

申请号：EP10821297.8

申请日：2010-09-30

申请人： Memorial Sloan-Kettering Cancer Center ,  Board of Regents, The University of Texas System

发明人： ALLISON, James ,  SHARMA, Padmanee ,  QUEZADA, Sergio, A. ,  FU, Tihui

IPC分类号： A61K39/395 ,  A61P35/00

CPC分类号： C07K16/2818 ,  A61K38/1709 ,  A61K39/3955 ,  A61K39/39558 ,  A61K2039/505 ,  A61K2039/507 ,  C07K16/2803 ,  C07K16/2827 ,  C07K2317/73 ,  C07K2317/74 ,  C07K2317/75 ,  C07K2317/76 ,  A61K2300/00

摘要： Agonists to ICOS in combination with a blocking agent to a T cell inhibitory receptor (e.g., CTLA-4, PD-I, etc.) are demonstrated herein to be useful for the treatment of tumors.