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公开(公告)号：EP3874036A1
公开(公告)日：2021-09-08
申请号：EP19806368.7
申请日：2019-10-31
发明人： GOLYNSKIY, Misha , MCDONALD, Seth , NIRANTAR, Saurabh , KELLINGER, Matthew , PREVITE, Michael , PEISAJOVICH, Sergio , HE, Molly
IPC分类号： C12N9/12 , C12Q1/6844
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2.发明公开
公开(公告)号：EP3201355A1
公开(公告)日：2017-08-09
申请号：EP15779120.3
申请日：2015-09-29
申请人： Illumina, Inc.
CPC分类号： C12N9/1252 , C12Q1/6844 , C12Q1/686 , C12Y207/07007 , C12Q2521/101
摘要： Presented herein are polymerase enzymes for improved incorporation of nucleotide analogs, in particular nucleotides which are modified at the 3′ sugar hydroxyl, as well as methods and kits using the same.
摘要翻译： 本文提供了用于改善核苷酸类似物掺入的聚合酶，特别是在3'糖羟基上修饰的核苷酸，以及使用其的方法和试剂盒。
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公开(公告)号：EP3143161A1
公开(公告)日：2017-03-22
申请号：EP15729968.6
申请日：2015-05-14
申请人： Illumina, Inc.
发明人： RONAGHI, Mostafa , HE, Molly , CHEN, Cheng-yao , PREVITE, Michael , BOWEN, Shane
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6874 , B01J19/0046 , B01J2219/00587 , B01J2219/00605 , B01J2219/00689 , B01J2219/00693 , B01J2219/00695 , B01J2219/00698 , B01J2219/00704 , B01J2219/00722 , C12Q2525/191 , C12Q2533/101 , C12Q2565/501 , C12Q2565/543
摘要： A method for synthesizing a nucleic acid includes synthesizing one or more nucleic acid fragments on a substrate. The synthesized one or more nucleic acid fragments may be amplified on the substrate. The method also includes sequencing the synthesized or amplified one or more nucleic acid fragments on the substrate. The sequencing may provide feedback to designs of the one or more nucleic acid fragments. The method further includes harvesting the synthesized or amplified one or more nucleic acid fragments based on sequencing. The synthesized or amplified one or more nucleic acid fragments may be assembled to generate a target nucleic acid.
摘要翻译： 合成核酸的方法包括在底物上合成一个或多个核酸片段。 合成的一个或多个核酸片段可以在底物上扩增。 该方法还包括对底物上合成或扩增的一个或多个核酸片段进行测序。 测序可以提供反馈到一个或多个核酸片段的设计。 该方法还包括基于测序收获合成的或扩增的一个或多个核酸片段。 可以组合合成或扩增的一个或多个核酸片段以产生靶核酸。
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公开(公告)号：EP4190912A1
公开(公告)日：2023-06-07
申请号：EP23152213.7
申请日：2016-05-09
申请人： Illumina, Inc.
发明人： BOUTELL, Jonathan Mark , GOLYNSKIY, Misha , HE, Molly , KELLINGER, Matthew William , PEISAJOVICH, Sergio , PREVITE, Michael
IPC分类号： C12Q1/68 , G01N33/53 , G01N33/573 , G01N33/569 , G01N21/76 , C12N15/10
摘要： A method of characterizing candidate agents including steps of (a) providing a library of candidate agents attached to nucleic acid tags; (b) contacting the library with a solid support to attach the candidate agents to the solid support, whereby an array of candidate agents is formed; (c) contacting the array with a screening agent, wherein one or more candidate agents in the array react with the screening agent; (d) detecting the array to determine that at least one candidate agent in the array reacts with the screening agent; (e) sequencing the nucleic acid tag to determine the tag sequences attached to candidate agents in the array; and (f) identifying the at least one candidate agent in the array that reacts with the screening agent based on the tag sequence that is attached to the at least one candidate agent.
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公开(公告)号：EP3822365A1
公开(公告)日：2021-05-19
申请号：EP20216661.7
申请日：2016-05-09
申请人： Illumina, Inc.
发明人： BOUTELL, Jonathan Mark , GOLYNSKIY, Misha , HE, Molly , KELLINGER, Matthew William , PEISAJOVICH, Sergio , PREVITE, Michael
IPC分类号： C12Q1/68 , G01N33/53 , G01N33/573 , G01N33/569 , G01N21/76 , C12N15/10
摘要： A method of characterizing candidate agents including steps of (a) providing a library of candidate agents attached to nucleic acid tags; (b) contacting the library with a solid support to attach the candidate agents to the solid support, whereby an array of candidate agents is formed; (c) contacting the array with a screening agent, wherein one or more candidate agents in the array react with the screening agent; (d) detecting the array to determine that at least one candidate agent in the array reacts with the screening agent; (e) sequencing the nucleic acid tag to determine the tag sequences attached to candidate agents in the array; and (f) identifying the at least one candidate agent in the array that reacts with the screening agent based on the tag sequence that is attached to the at least one candidate agent.
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公开(公告)号：EP3760737A2
公开(公告)日：2021-01-06
申请号：EP20191289.6
申请日：2016-05-09
申请人： Illumina, Inc.
发明人： HE, Molly , PREVITE, Michael , GOLYNSKIY, Misha , KELLINGER, Matthew William , PEISAJOVICH, Sergio , BOUTELL, Jonathan Mark
IPC分类号： C12Q1/68 , G01N33/53 , G01N33/573 , G01N33/569 , G01N21/76 , C12N15/10
摘要： A method of characterizing candidate agents including steps of (a) providing a library of candidate agents attached to nucleic acid tags; (b) contacting the library with a solid support to attach the candidate agents to the solid support, whereby an array of candidate agents is formed; (c) contacting the array with a screening agent, wherein one or more candidate agents in the array react with the screening agent; (d) detecting the array to determine that at least one candidate agent in the array reacts with the screening agent; (e) sequencing the nucleic acid tag to determine the tag sequences attached to candidate agents in the array; and (f) identifying the at least one candidate agent in the array that reacts with the screening agent based on the tag sequence that is attached to the at least one candidate agent.
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公开(公告)号：EP4314327A1
公开(公告)日：2024-02-07
申请号：EP22715858.1
申请日：2022-03-21
发明人： SKINNER, Gary, Mark , EVANS, Geraint , GORMLEY, Niall , BOUTELL, Jonathan , KELLINGER, Matthew, W. , PREVITE, Michael , HE, Molly
IPC分类号： C12Q1/6806 , C12Q1/6837
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公开(公告)号：EP3760737A3
公开(公告)日：2021-02-17
申请号：EP20191289.6
申请日：2016-05-09
申请人： Illumina, Inc.
发明人： HE, Molly , PREVITE, Michael , GOLYNSKIY, Misha , KELLINGER, Matthew William , PEISAJOVICH, Sergio , BOUTELL, Jonathan Mark
IPC分类号： C12Q1/68 , G01N33/53 , G01N33/573 , G01N33/569 , G01N21/76 , C12N15/10
摘要： A method of characterizing candidate agents including steps of (a) providing a library of candidate agents attached to nucleic acid tags; (b) contacting the library with a solid support to attach the candidate agents to the solid support, whereby an array of candidate agents is formed; (c) contacting the array with a screening agent, wherein one or more candidate agents in the array react with the screening agent; (d) detecting the array to determine that at least one candidate agent in the array reacts with the screening agent; (e) sequencing the nucleic acid tag to determine the tag sequences attached to candidate agents in the array; and (f) identifying the at least one candidate agent in the array that reacts with the screening agent based on the tag sequence that is attached to the at least one candidate agent.
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公开(公告)号：EP3294911B1
公开(公告)日：2020-08-19
申请号：EP16793337.3
申请日：2016-05-09
申请人： Illumina, Inc.
发明人： HE, Molly , PREVITE, Michael , GOLYNSKIY, Misha , KELLINGER, Matthew William , PEISAJOVICH, Sergio , BOUTELL, Jonathan Mark
IPC分类号： C12Q1/68 , G01N33/53 , G01N33/573 , G01N33/569 , G01N21/76 , C12N15/10
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