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    IMAGE SENSOR STRUCTURES AND METHOD
    2.
    发明公开
    IMAGE SENSOR STRUCTURES AND METHOD 审中-公开

    公开(公告)号：EP4050327A1

    公开(公告)日：2022-08-31

    申请号：EP22168476.4

    申请日：2018-12-17

    申请人： Illumina, Inc.

    发明人： CAI, Xiuyu ,  AGAH, Ali ,  FUNG, Tracy ,  DEHLINGER, Dietrich

    IPC分类号： G01N21/64 ,  G01J1/44 ,  G01J1/02 ,  H01L27/146 ,  G01N21/05

    摘要： An example image sensor structure includes an image layer with an array of light detectors disposed therein. A device stack is disposed over the image layer, with an array of light guides disposed therein. Each light guide is associated with at least one light detector of the array of light detectors. A passivation stack is disposed over the device stack, comprising a passivation layer and a chemical protection layer disposed over the passivation layer, and preferably including a bottom surface in direct contact with a top surface of the light guides. An array of nanowells is disposed in a top layer of the passivation stack, with the contours of the nanowells formed by a top layer of the passivation stack. Each nanowell is associated with a light guide. A crosstalk blocking metal structure is disposed in the passivation stack, which reduces crosstalk within the passivation stack.

    HIGH-THROUGHPUT SEQUENCING WITH SEMICONDUCTOR-BASED DETECTION
    6.
    发明公开
    HIGH-THROUGHPUT SEQUENCING WITH SEMICONDUCTOR-BASED DETECTION 审中-公开

    公开(公告)号：EP3913358A1

    公开(公告)日：2021-11-24

    申请号：EP21184096.2

    申请日：2019-01-07

    申请人： Illumina Inc

    发明人： DEHLINGER, Dietrich ,  AGAH, Ali ,  FUNG, Helen Tracy ,  KOSTEM, Emrah

    IPC分类号： G01N21/64 ,  B01L3/00 ,  G01N21/76 ,  B01L7/00 ,  C12Q1/6869

    摘要： A biosensor (102, 300) for base calling is provided. The biosensor (102, 300) comprises a sampling device (304), which includes a sample surface (334) that has an array of pixel areas (306', 308', 310', 312', 314') and a solid-state imager that has an array of sensors (306, 308, 310, 312, 314). Each sensor (306, 308, 310, 312, 314) generates pixel signals in each base calling cycle. Each pixel signal represents light gathered from a corresponding pixel area (306', 308', 310', 312', 314') of the sample surface (334). The biosensor (102, 300) further comprises a signal processor (130) configured for connection to the sampling device (304). The signal processor (130) receives and processes the pixel signals from the sensors (306, 308, 310, 312, 314) for base calling in a base calling cycle, and uses the pixel signals from fewer sensors (306, 308, 310, 312, 314) than a number of clusters (306AB, 308AB, 310AB, 312AB, 314AB) base called in the base calling cycle.

    PHOTONIC SUPERLATTICE-BASED DEVICES AND COMPOSITIONS FOR USE IN LUMINESCENT IMAGING, AND METHODS OF USING THE SAME
    9.
    发明公开
    PHOTONIC SUPERLATTICE-BASED DEVICES AND COMPOSITIONS FOR USE IN LUMINESCENT IMAGING, AND METHODS OF USING THE SAME 审中-公开

    公开(公告)号：EP4053545A1

    公开(公告)日：2022-09-07

    申请号：EP22164882.7

    申请日：2017-03-23

    申请人： Illumina, Inc.

    发明人： DEHLINGER, Dietrich ,  ZHONG, Cheng, Frank ,  TOPOLANCIK, Juraj

    IPC分类号： G01N21/64 ,  G02B5/20 ,  G02B21/00 ,  G02B21/18 ,  G02B21/36 ,  B01L3/00 ,  G01N21/03 ,  G01N21/25

    摘要： A device (300) is provided for use in luminescent imaging. The device (300) includes a photonic superlattice (310) including a first material, the first material having a first refractive index. The first material includes first and second major surfaces (311, 312) and first and second pluralities of wells (313, 314) defined though at least one of the first and second major surfaces (311, 312), the wells (313) of the first plurality differing in at least their size from the wells (314) of the second plurality. The photonic superlattice (310) supports propagation of a first wavelength (λ 1 ) and a second wavelength (λ 2 ) approximately at a first angle out of the photonic superlattice (310), the first and second wavelengths (λ 1 , λ 2 ) being separated from one another by a first non-propagating wavelength that does not selectively propagate at the first angle out of the photonic superlattice (310). The device (300) further can include a second material having a second refractive index that is different than the first refractive index. The second material can be disposed within, between, or over the first and second pluralities of wells and can include first and second luminophores (321, 322). The device (300) further includes a first optical component (330) disposed over one of the first and second major surfaces (311, 312) of the first material. The first optical component (330) receives luminescence emitted by the first luminophore (321) at the first wavelength (λ 1 ) approximately at the first angle, and receives luminescence emitted by the second luminophore (322) at the second wavelength (λ 2 ) approximately at the first angle.