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    SENSORS HAVING INTEGRATED PROTECTION CIRCUITRY
    3.
    发明公开
    SENSORS HAVING INTEGRATED PROTECTION CIRCUITRY 审中-公开

    公开(公告)号：EP4075135A1

    公开(公告)日：2022-10-19

    申请号：EP22177086.0

    申请日：2018-04-19

    申请人： Illumina, Inc.

    发明人： FUNG, Tracy Helen ,  CAI, Xiuyu ,  KWOK, Lisa ,  TRAN, Hai ,  SAMIEE, Kevan ,  QIANG, Liangliang ,  BOYANOV, Boyan

    IPC分类号： G01N33/543 ,  C12Q1/68 ,  G01N21/62 ,  G01N21/64 ,  G01N21/77 ,  B01L3/00

    摘要： An example sensor includes a detection device, including an optical waveguide, an optical sensor operatively associated with the optical waveguide and a device circuitry, including a reagent electrode, a first embedded metal layer electrically connected to the reagent electrode; and a second embedded metal layer electrically connected to the optical sensor wherein the first embedded metal layer is spaced from the second embedded metal layer by an electrically isolating gap, at least a portion of a passivation layer being in contact with the first embedded metal layer and an input region of the optical waveguide, the at least the portion of the passivation layer having a reaction site at least partially adjacent to the input region of the optical waveguide; and a lid operatively connected to the passivation layer to partially define a flow channel between the lid and the reaction site, wherein the reagent electrode is positioned to be in contact with a reagent to be introduced into the flow channel. A method for performing a sensing operation of a sensor in response to a reaction at the reaction site involving at least some reaction component of the reagent and during the sensing operation, applying an electrical bias that renders the reagent electrode one of an anode or a cathode and the embedded metal layer the other of the cathode or the anode, thereby providing cathodic protection or anodic protection to the embedded metal layer, is also disclosed.

    DEVICES FOR HIGH-THROUGHPUT SEQUENCING WITH SEMICONDUCTOR-BASED DETECTION
    4.
    发明公开
    DEVICES FOR HIGH-THROUGHPUT SEQUENCING WITH SEMICONDUCTOR-BASED DETECTION 审中-公开

    公开(公告)号：EP3957982A1

    公开(公告)日：2022-02-23

    申请号：EP21194143.0

    申请日：2019-01-07

    申请人： Illumina, Inc.

    发明人： DEHLINGER, Dietrich ,  FUNG, Tracy Helen ,  AGAH, Ali ,  KOSTEM, Emrah ,  HETHERINGTON, Craig

    IPC分类号： G01N21/64 ,  B01L3/00 ,  C12Q1/68 ,  C40B30/04 ,  H01L27/146 ,  C40B50/14 ,  G01N21/76 ,  B01L7/00 ,  C12Q1/6869

    摘要： In one embodiment, a sample surface of a biosensor includes pixel areas and holds a plurality of clusters during a sequence of sampling events such that the clusters are distributed unevenly over the pixel areas. In another embodiment, a biosensor has a sample surface that includes pixel areas and an array of wells overlying the pixel areas, the biosensor including two wells and two clusters per pixel area. The two wells per pixel area include a dominant well and a subordinate well. The dominant well has a larger cross section over the pixel area than the subordinate well. In another embodiment, an illumination system is coupled to a biosensor that illuminates the pixel areas (1204', 1214') with different angles of illumination (1201, 1211) during a sequence of sampling events, including, for a sampling event, illuminating each of the wells (1202, 1212) with off-axis illumination (1200A, 1200B) to produce asymmetrically illuminated well regions in each of the wells (1202, 1212).