公开(公告)号：EP2121739A1

公开(公告)日：2009-11-25

申请号：EP08712277.6

申请日：2008-02-01

申请人： Imagene Co., Ltd.

发明人： KIM, Sunghoon ,  HAN, Jung Min ,  PARK, Sang Gyu ,  LEE, Yoen Sook

IPC分类号： C07K14/47 ,  C12N15/12

CPC分类号： C07K14/4747

摘要： The present invention relates to a novel polypeptide having ant i- tumor activity through inducing apoptosis of endothelial cell and use thereof. More particularly, the present invention relates to a method for inducing apoptosis of endothelial cell, and for preventing or treating cancer, comprising administering to a subject in need thereof an effective amount of (a) an isolated polypeptide having the amino acid sequence of SEQ ID NO: 9 or the amino acid sequence having at least 90% sequence homology to the amino acid sequence of SEQ ID NO: 9; or (b) an isolated polynucleotide encoding the polypeptide of (a).