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公开(公告)号：EP2121739A1
公开(公告)日：2009-11-25
申请号：EP08712277.6
申请日：2008-02-01
申请人： Imagene Co., Ltd.
发明人： KIM, Sunghoon , HAN, Jung Min , PARK, Sang Gyu , LEE, Yoen Sook
CPC分类号： C07K14/4747
摘要： The present invention relates to a novel polypeptide having ant i- tumor activity through inducing apoptosis of endothelial cell and use thereof. More particularly, the present invention relates to a method for inducing apoptosis of endothelial cell, and for preventing or treating cancer, comprising administering to a subject in need thereof an effective amount of (a) an isolated polypeptide having the amino acid sequence of SEQ ID NO: 9 or the amino acid sequence having at least 90% sequence homology to the amino acid sequence of SEQ ID NO: 9; or (b) an isolated polynucleotide encoding the polypeptide of (a).
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2.发明授权DEATH EFFECTOR DOMAIN OF MAMMALIAN APOPTOSIS MEDIATOR, FADD, INDUCING BACTERIAL CELL DEATH 有权“死亡效应”哺乳动物细胞凋亡介体结构域，FADD，细菌细胞死亡触发器
公开(公告)号：EP1198476B1
公开(公告)日：2006-09-06
申请号：EP00942486.2
申请日：2000-07-11
发明人： KIM, Sunghoon , KIM, Key-Sun
CPC分类号： C07K14/715
摘要： The present invention relates to a death effector domain, FADD-DED (SEQ ID NO: 3) of mammalian apoptosis mediator, FADD (SEQ ID NO: 2) encoded by cDNA clone (SEQ ID NO: 1), wherein FADD-DED induces baterial cell death as well as mammalian cell death by enhancing cellular level of Reactive Oxygen Species (ROS).
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公开(公告)号：EP2121739A4
公开(公告)日：2010-03-10
申请号：EP08712277
申请日：2008-02-01
申请人： IMAGENE CO LTD
发明人： KIM SUNGHOON , HAN JUNG MIN , PARK SANG GYU , LEE YOEN SOOK
CPC分类号： C07K14/4747
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公开(公告)号：EP1976864B1
公开(公告)日：2012-09-26
申请号：EP06702901.7
申请日：2006-01-23
申请人： Imagene Co., Ltd.
发明人： KIM, Sung-hoon , HAN, Jung-min
CPC分类号： C07K14/47
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5.发明公开DEATH EFFECTOR DOMAIN OF MAMMALIAN APOPTOSIS MEDIATOR, FADD, INDUCING BACTERIAL CELL DEATH 有权“死亡效应”哺乳动物细胞凋亡介体结构域，FADD，细菌细胞死亡触发器
公开(公告)号：EP1198476A1
公开(公告)日：2002-04-24
申请号：EP00942486.2
申请日：2000-07-11
发明人： KIM, Sunghoon , KIM, Key-Sun
CPC分类号： C07K14/715
摘要： The present invention relates to a death effector domain, FADD-DED (SEQ ID NO: 3) of mammalian apoptosis mediator, FADD (SEQ ID NO: 2) encoded by cDNA clone (SEQ ID NO: 1), wherein FADD-DED induces baterial cell death as well as mammalian cell death by enhancing cellular level of Reactive Oxygen Species (ROS).
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公开(公告)号：EP1976864A4
公开(公告)日：2010-09-01
申请号：EP06702901
申请日：2006-01-23
申请人： IMAGENE CO LTD
发明人： KIM SUNG-HOON , HAN JUNG-MIN
CPC分类号： C07K14/47
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公开(公告)号：EP1976864A1
公开(公告)日：2008-10-08
申请号：EP06702901.7
申请日：2006-01-23
申请人： Imagene Co., Ltd.
发明人： KIM, Sung-hoon , HAN, Jung-min
CPC分类号： C07K14/47
摘要： The present invention relates to a novel peptide and use thereof, more particularly to an isolated peptide comprising 21-41 contiguous amino acids selected from the amino acid sequence of SEQ ID NO: 1 or the amino acid sequence having at least 90% sequence homology to the amino acid sequence of SEQ ID NO: 1 and methods for promoting fibroblast proliferation and wound healing, which comprise administering to a subject in need thereof an effective amount of the peptide.
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