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1.发明公开
公开(公告)号：EP3713554A1
公开(公告)日：2020-09-30
申请号：EP18803724.6
申请日：2018-11-22
申请人： Immunic AG
发明人： GRÖPPEL, Manfred , VITT, Daniel , KOHLHOF,Hella , MÜHLER, Andreas
IPC分类号： A61K31/192 , A61P29/00
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公开(公告)号：EP4452929A1
公开(公告)日：2024-10-30
申请号：EP22844140.8
申请日：2022-12-23
申请人： Immunic AG
发明人： GEGE, Christian , MÜHLER, Andreas , KOHLHOF, Hella , VITT, Daniel
IPC分类号： C07C233/60 , A61P29/00 , A61P35/00 , A61K31/192
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公开(公告)号：EP4426315A1
公开(公告)日：2024-09-11
申请号：EP22813903.6
申请日：2022-11-01
申请人： Immunic AG
发明人： GEGE, Christian , KOHLHOF, Hella , MÜHLER, Andreas , VITT, Daniel
IPC分类号： A61K31/7068 , A61P31/12 , A61P31/14 , A61P31/16 , A61P31/18
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公开(公告)号：EP4320100A1
公开(公告)日：2024-02-14
申请号：EP22721769.2
申请日：2022-04-08
申请人： Immunic AG
发明人： GEGE, Christian , KOHLHOF, Hella , MÜHLER, Andreas , VITT, Daniel
IPC分类号： C07D213/30 , C07D265/30 , C07D277/24 , C07D333/24
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公开(公告)号：EP3900717A1
公开(公告)日：2021-10-27
申请号：EP21169334.6
申请日：2021-04-20
申请人： Immunic AG
IPC分类号： A61K31/196 , A61K31/706 , A61P31/14
摘要： The present invention relates to a compound according to Formula (I)
or a salt, solvate and/or a hydrate thereof, wherein said compound inhibits dihydroorotate dehydrogenase (DHODH), for use in the treatment and prevention of viral infection. A preferred example is viral infection caused by coronavirus, in particular betacoronavirus, more particular SARS-CoV-2 and mutated versions thereof.-
6.发明公开
公开(公告)号：EP3765439A1
公开(公告)日：2021-01-20
申请号：EP19711350.9
申请日：2019-03-15
申请人： Immunic AG
IPC分类号： C07C233/60 , A61K31/16 , A61P37/00
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7.发明公开
公开(公告)号：EP4438591A1
公开(公告)日：2024-10-02
申请号：EP24172742.9
申请日：2019-03-15
申请人： Immunic AG
IPC分类号： C07C233/60 , A61K31/16 , A61P37/00
CPC分类号： C07C233/60
摘要： Subject matter of the present invention is a white crystalline polymorph A of the Ca salt of a compound according to formula I or a solvate and/or a hydrate thereof with a molar ratio of a compound according to formula I or a solvate and/or a hydrate thereof to calcium which is 2±0.3. Subject matter of the present invention is in particular a compound according to formula I or a solvate and/or a hydrate thereof which is characterized by an X-ray powder diffraction pattern having characteristic peaks expressed in degrees 2theta at ±0.2 of the values shown below: 2 theta = 5.91°, 9.64°, 16.78°, 17.81°, 19.81°, 25.41° In particular the invention refers to new polymorphs of calcium salts of the Ca salt of a compound according to formula I or a solvate and/or a hydrate thereof which inhibits dihydroorotate dehydrogenase (DHODH), a process for their manufacture, pharmaceutical compositions containing them and to their use for the treatment and prevention of diseases, in particular their use in diseases where there is an advantage in inhibiting dihydroorotate dehydrogenase (DHODH).
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公开(公告)号：EP4074708A1
公开(公告)日：2022-10-19
申请号：EP22176185.1
申请日：2018-09-06
申请人： Immunic AG
发明人： FELDING, Jakob , KOHLHOF, Hella , GRÖPPEL, Manfred , MÜHLER, Rolf Andreas , VITT, Daniel , CHEVRIER, Carine , ZAJA, Mirko , TASLER, Stefan
IPC分类号： C07D413/04 , A61K31/4155 , A61P37/00 , A61P17/06 , A61P5/14 , A61P1/04 , A61P9/10
摘要： The present invention relates to compounds of the general formula (I), and the pharmaceutically acceptable salts and solvates thereof, wherein Ar, Z and Y are as described herein and R1 is a group of the structure
wherein n is 0 or 1; R2 is H, deuterium or methyl; R3 is methyl, trifluoromethyl, ethyl, or taken with R2 together forms a cyclopropyl group, or R3 forms a methylene bridge to the carbon atom marked ∗ , which are suitable for the treatment of autoimmune diseases and chronic inflammation.-
公开(公告)号：EP3679034A1
公开(公告)日：2020-07-15
申请号：EP18762111.5
申请日：2018-09-06
申请人： Immunic AG
发明人： FELDING, Jakob , KOHLHOF, Hella , GRÖPPEL, Manfred , MÜHLER, Rolf Andreas , VITT, Daniel , CHEVRIER, Carine , ZAJA, Mirko , TASLER, Stefan
IPC分类号： C07D413/04 , A61K31/4155 , A61P37/00 , A61P17/06 , A61P5/14 , A61P1/04 , A61P9/10
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