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公开(公告)号：EP3558391A1
公开(公告)日：2019-10-30
申请号：EP17835533.5
申请日：2017-12-21
申请人： Immunogen, Inc. , MacroGenics, Inc.
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公开(公告)号：EP3814378A1
公开(公告)日：2021-05-05
申请号：EP19748615.2
申请日：2019-06-25
申请人： ImmunoGen, Inc. , MacroGenics, Inc.
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3.发明公开TRI-SPECIFIC BINDING MOLECULES AND METHODS OF USE THEREOF 审中-公开维多利亚·维尔多瓦·达文（VERFAHREN ZUR VERWENDUNG DAVON）的TRISPEZIFISCHEBINDEMOLEKÜLE
公开(公告)号：EP3152235A1
公开(公告)日：2017-04-12
申请号：EP15799237.1
申请日：2015-05-29
申请人： MacroGenics, Inc.
发明人： JOHNSON, Leslie, S. , HUANG, Ling , CHICHILI, Gurunadh, Reddy , SHAH, Kalpana , LAM, Chia-Ying, Kao , BURKE, Stephen, James , LIU, Liqin , MOORE, Paul, A. , BONVINI, Ezio , BARAT, Bhaswati
IPC分类号： C07K16/18
CPC分类号： C07K16/28 , C07K16/2803 , C07K16/2809 , C07K16/2815 , C07K16/2827 , C07K16/283 , C07K16/2878 , C07K16/30 , C07K2317/31 , C07K2317/524 , C07K2317/526 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/626 , C07K2317/73 , C07K2317/92 , C07K2318/20 , C07K2319/00
摘要： The present invention relates to Tri-Specific Binding Molecules, which are multichain polypeptide molecules that possess three Binding Domains and are thus capable of mediating coordinated binding to three epitopes. The Binding Domains may be selected such that the Tri-Specific Binding Molecules are capable of binding to any three different epitopes. Such epitopes may be epitopes of the same antigen or epitopes of two or three different antigens. In a preferred embodiment, one of such epitopes will be capable of binding to CD3, the second of such epitopes will be capable of binding to CD8, and the third of such epitopes will be capable of binding to an epitope of a Disease-Associated Antigen. The invention also provides a novel ROR1-binding antibody, as well as derivatives thereof and uses for such compositions.
摘要翻译： 本发明涉及三特异性结合分子，其是具有三个结合域的多链多肽分子，因此能够介导与三个表位的协调结合。 三特异性结合分子的特征在于具有结合域，其允许其免疫特异性结合：（1）第一癌抗原的表位，（2）第二癌抗原的表位，和（3） 在免疫系统效应细胞的表面上表达的分子，因此能够将免疫系统效应细胞定位于表达癌抗原的细胞，从而有助于杀死这种癌细胞。
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4.发明公开DEIMMUNIZED SERUM-BINDING DOMAINS AND THEIR USE FOR EXTENDING SERUM HALF-LIFE 有权ENTIMMUNISIERTE血清结合域及其使用再生精华半衰期
公开(公告)号：EP2714079A2
公开(公告)日：2014-04-09
申请号：EP12789439.2
申请日：2012-05-16
申请人： MacroGenics, Inc.
IPC分类号： A61K39/395
CPC分类号： C07K16/32 , A61P35/00 , C07K14/315 , C07K16/2803 , C07K16/2809 , C07K16/283 , C07K16/2851 , C07K16/44 , C07K2317/24 , C07K2317/31 , C07K2317/567 , C07K2317/62 , C07K2317/624 , C07K2317/626 , C07K2317/73 , C07K2317/76 , C07K2317/90 , C07K2317/92 , C07K2319/31 , C07K2319/32 , C07K2319/73
摘要： The present invention is directed to a polypeptide (for example, an antigen-binding molecule) that comprises a polypeptide portion of a deimmunized serum-binding protein capable of binding to said serum protein. The presence of the serum-binding protein extends the serum half-life of the polypeptide, relative to the serum half-life of the polypeptide if lacking the polypeptide portion of the deimmunized serum-binding protein. The invention also pertains to methods and uses that employ such molecules.
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公开(公告)号：EP3954703A3
公开(公告)日：2022-05-18
申请号：EP21185550.7
申请日：2015-05-29
申请人： MacroGenics, Inc.
发明人： JOHNSON, Leslie S. , HUANG, Ling , CHICHILI, Gurunadh Reddy , SHAH, Kalpana , LAM, Chia-Ying, Kao , BURKE, Stephen, James , LIU, Liqin , MOORE, Paul, A. , BONVINI, Ezio , BARAT, Bhaswati
IPC分类号： C07K16/18 , C07K16/28 , C07K16/30 , A61P1/04 , A61P1/16 , A61P5/00 , A61P9/10 , A61P11/00 , A61P13/10 , A61P13/12 , A61P17/00 , A61P19/00 , A61P21/00 , A61P35/02 , A61P35/00 , A61P35/04 , A61P1/18 , A61P13/00 , A61P13/08 , A61P15/00 , A61P25/00
摘要： The present invention relates to Tri-Specific Binding Molecules, which are multi-chain polypeptide molecules that possess three Binding Domains and are thus capable of mediating coordinated binding to three epitopes. The Binding Domains may be selected such that the Tri-Specific Binding Molecules are capable of binding to any three different epitopes. Such epitopes may be epitopes of the same antigen or epitopes of two or three different antigens. In a preferred embodiment, one of such epitopes will be capable of binding to CD3, the second of such epitopes will be capable of binding to CD8, and the third of such epitopes will be capable of binding to an epitope of a Disease-Associated Antigen. The invention also provides a novel ROR1-binding antibody, as well as derivatives thereof and uses for such compositions.
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公开(公告)号：EP3558368A1
公开(公告)日：2019-10-30
申请号：EP17882545.1
申请日：2017-12-21
申请人： MacroGenics, Inc.
发明人： LOO, Deryk, T. , SCRIBNER, Juniper, A. , BARAT, Bhaswati , DIEDRICH, Gundo , JOHNSON, Leslie, S. , BONVINI, Ezio
IPC分类号： A61K39/395 , A61P35/04 , C07K16/18 , C07K16/40
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公开(公告)号：EP2714079B2
公开(公告)日：2019-08-28
申请号：EP12789439.2
申请日：2012-05-16
申请人： MacroGenics, Inc.
IPC分类号： A61K39/395 , C07K16/28 , C07K16/32 , C07K16/44
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公开(公告)号：EP3954703A2
公开(公告)日：2022-02-16
申请号：EP21185550.7
申请日：2015-05-29
申请人： MacroGenics, Inc.
发明人： JOHNSON, Leslie S. , HUANG, Ling , CHICHILI, Gurunadh Reddy , SHAH, Kalpana , LAM, Chia-Ying, Kao , BURKE, Stephen, James , LIU, Liqin , MOORE, Paul, A. , BONVINI, Ezio , BARAT, Bhaswati
IPC分类号： C07K16/18 , C07K16/28 , C07K16/30 , A61P1/04 , A61P1/16 , A61P5/00 , A61P9/10 , A61P11/00 , A61P13/10 , A61P13/12 , A61P17/00 , A61P19/00 , A61P21/00 , A61P35/02 , A61P35/00 , A61P35/04 , A61P1/18 , A61P13/00 , A61P13/08 , A61P15/00 , A61P25/00
摘要： The present invention relates to Tri-Specific Binding Molecules, which are multi-chain polypeptide molecules that possess three Binding Domains and are thus capable of mediating coordinated binding to three epitopes. The Binding Domains may be selected such that the Tri-Specific Binding Molecules are capable of binding to any three different epitopes. Such epitopes may be epitopes of the same antigen or epitopes of two or three different antigens. In a preferred embodiment, one of such epitopes will be capable of binding to CD3, the second of such epitopes will be capable of binding to CD8, and the third of such epitopes will be capable of binding to an epitope of a Disease-Associated Antigen. The invention also provides a novel ROR1-binding antibody, as well as derivatives thereof and uses for such compositions.
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9.发明授权DEIMMUNIZED SERUM-BINDING DOMAINS AND THEIR USE FOR EXTENDING SERUM HALF-LIFE 有权ENTIMMUNISIERTE血清结合域及其使用再生精华半衰期
公开(公告)号：EP2714079B1
公开(公告)日：2016-09-14
申请号：EP12789439.2
申请日：2012-05-16
申请人： MacroGenics, Inc.
IPC分类号： A61K39/395 , C07K16/28 , C07K16/32 , C07K16/44
CPC分类号： C07K16/32 , A61P35/00 , C07K14/315 , C07K16/2803 , C07K16/2809 , C07K16/283 , C07K16/2851 , C07K16/44 , C07K2317/24 , C07K2317/31 , C07K2317/567 , C07K2317/62 , C07K2317/624 , C07K2317/626 , C07K2317/73 , C07K2317/76 , C07K2317/90 , C07K2317/92 , C07K2319/31 , C07K2319/32 , C07K2319/73
摘要： The present invention is directed to a polypeptide (for example, an antigen-binding molecule) that comprises a polypeptide portion of a deimmunized serum-binding protein capable of binding to said serum protein. The presence of the serum-binding protein extends the serum half-life of the polypeptide, relative to the serum half-life of the polypeptide if lacking the polypeptide portion of the deimmunized serum-binding protein. The invention also pertains to methods and uses that employ such molecules.
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