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公开(公告)号：EP3165237A1
公开(公告)日：2017-05-10
申请号：EP16196898.7
申请日：2016-11-02
发明人： KO, Yi-Ju , LI, Jheng-Sian , LU, Maggie , LEE, On , CHENG, Ping-Fu , LIU, Chun-Min
IPC分类号： A61K47/38
CPC分类号： C07K7/02 , A61K47/551 , A61K47/6817 , A61K47/6889 , C07K5/0207
摘要： An antibody-drug conjugate (ADC) of formula (I) or a pharmaceutically acceptable salt or solvate thereof is provided. In formula (I), p is an integer ranging from 1 to 26, A is an antibody, and -(L-D) is a linker-drug unit. L is a linker unit having a glycopeptide, and D is a drug unit. The antibody is conjugated to the linker unit through a cysteine residue of the antibody. A method for forming an antibody-drug conjugate (ADC) is also provided.
摘要翻译： 提供式（I）的抗体 - 药物缀合物（ADC）或其药学上可接受的盐或溶剂化物。 式（I）中，p为1至26的整数，A为抗体， - （L-D）为接头 - 药物单元。 L是具有糖肽的接头单元，D是药物单元。 抗体通过抗体的半胱氨酸残基缀合至接头单元。 还提供了形成抗体 - 药物缀合物（ADC）的方法。
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2.发明公开
公开(公告)号：EP4368626A1
公开(公告)日：2024-05-15
申请号：EP23209387.2
申请日：2023-11-13
发明人： CHENG, Felice , CHENG, Ping-Fu , HWANG, Jenn-Tsang , FU, Chih-Wei , LIN, Ku-Feng , CHIU, Ya-Ling , LI, Jheng-Sian , WANG, Kang-Li , CHANG, Siou-Han , FAN, Chia-Yu
IPC分类号： C07F9/09 , C07F9/12 , C07F9/53 , C07F9/6509 , C07F9/6512
CPC分类号： C07F9/6512 , C07F9/5304 , C07F9/091 , C07F9/532 , C07F9/650952 , C07F9/12 , A61K9/127
摘要： A lipid compound or a derivative thereof and a pharmaceutical composition employing the same are provided. The lipid compound has a structure represented by Formula (I):
wherein Z1, Z2, Z3 and Z4 are as disclosed in the specification.-
公开(公告)号：EP3335734A1
公开(公告)日：2018-06-20
申请号：EP17207834.7
申请日：2017-12-15
发明人： LU, Maggie , CHANG, May-Hua , HWANG, Jenn-Tsang , CHENG, Ping-Fu , CHANG, Li-Wen , KO, Yi-Ju , HUNG, Chi-Y , LIU, Chun-Min , FAN, Chia-Yu
CPC分类号： A61K47/6889 , A61K31/4745 , A61K47/64 , A61K47/65 , A61K47/6803 , A61K47/6817 , A61K47/6851 , A61K47/6855 , A61P35/00 , C07K16/30
摘要： A linker-drug represented by formula (I). In formula (I), C is a conjugating linker, L is a linker unit, D is a drug unit, and n is an integer ranging from 1 to 4. The structure of the conjugating linker is represented by formula (II). In formula (II), X is a leaving group, both of R 1 and R 2 are single bond or -NH- and Z is aryl, substituted aryl, heteroaryl, substituted heteroaryl, linear alkyl, cycloalkyl, heterocycloalkyl, or a combination thereof. The wave line of formula (II) indicates the covalent attachment site to L. The antibody is conjugated to the linker unit through a cysteine residue of the antibody. An antibody-drug conjugate (ADC) is also provided.
C-(L-D) m (I)-
4.发明公开
公开(公告)号：EP2391654A1
公开(公告)日：2011-12-07
申请号：EP10735454.0
申请日：2010-01-27
发明人： LIN, Wei-Ya , YEH , Mary Ya-Ping , TSENG, Tzu-Ling , CHENG, Ping-Fu , HSU, Tsai-Wei , LI, Hung-Yi , CHEN, Yi-Ting , LIN, Yuh-Feng , CHEN, Giien-Shuen , LI , Yen-Peng
IPC分类号： C07K16/38 , C07K16/18 , C40B30/00 , G01N33/53 , G01N33/573 , G01N33/68 , C07K14/81 , C07K14/47
CPC分类号： G01N33/6893 , G01N2333/4728 , G01N2333/52 , G01N2333/71 , G01N2333/8125 , G01N2800/347 , G01N2800/52 , G01N2800/56
摘要： Use of urine and serum biomarkers in diagnosing diabetic nephropathy, staging diabetic nephropathy, monitoring diabetic nephropathy progress, and assessing efficacy of diabetic nephropathy treatments. These biomarkers include urine precursor alpha-2-HS-glycoprotein, urine alpha- 1 antitrypsin, urine alpha- 1 acid glycoprotein, urine osteopontin, serum osteopontin, their fragments, and combinations thereof.
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公开(公告)号：EP3845649A1
公开(公告)日：2021-07-07
申请号：EP20217127.8
申请日：2020-12-23
发明人： CHENG, Ping-Fu , CHIU, Ya-Ling , WANG, Kang-Li , LIN, Po-Yen , CHEN, Shih-Ta , LIU, Tseng-Huang , JIANG, Pei-Shin
IPC分类号： C12N15/115 , C12N15/117 , A61K31/7125 , A61P35/00
摘要： A nucleic acid-drug complex is provided in the present disclosure, which includes a nucleic acid sequence of an anti-PD-Ll aptamer and a CpG oligonucleotide sequence capable of activating TLR9, in which the CpG oligonucleotide sequence consists of a first fragment and a second fragment, and the nucleic acid sequence of the anti-PD-Ll aptamer is inserted between the first fragment and the second fragment.
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6.发明授权
公开(公告)号：EP2391654B1
公开(公告)日：2015-09-09
申请号：EP10735454.0
申请日：2010-01-27
发明人： LIN, Wei-Ya , YEH , Mary Ya-Ping , TSENG, Tzu-Ling , CHENG, Ping-Fu , HSU, Tsai-Wei , LI, Hung-Yi , CHEN, Yi-Ting , LIN, Yuh-Feng , CHEN, Giien-Shuen , LI , Yen-Peng
IPC分类号： C07K16/38 , C07K16/18 , C40B30/00 , G01N33/53 , G01N33/573 , G01N33/68 , C07K14/81 , C07K14/47
CPC分类号： G01N33/6893 , G01N2333/4728 , G01N2333/52 , G01N2333/71 , G01N2333/8125 , G01N2800/347 , G01N2800/52 , G01N2800/56
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