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    COMPOSITIONS FOR STIMULATING CYTOKINE SECRETION AND INDUCING AN IMMUNE RESPONSE
    2.
    发明公开
    COMPOSITIONS FOR STIMULATING CYTOKINE SECRETION AND INDUCING AN IMMUNE RESPONSE 有权
    组合物细胞因子分泌的刺激和诱导的免疫反应

    公开(公告)号：EP1212085A2

    公开(公告)日：2002-06-12

    申请号：EP00956004.6

    申请日：2000-08-28

    申请人： Inex Pharmaceuticals Corp.

    发明人： SEMPLE, Sean, C. ,  HARASYM, Troy, O. ,  KLIMUK, Sandra, K. ,  KOJIC, Ljiljiana, D. ,  BRAMSON, Jonathan, L. ,  MUI, Barbara ,  HOPE, Michael, J.

    IPC分类号： A61K39/39 ,  A61K31/7088 ,  A61K9/127 ,  A61P37/04 ,  A61K35/00

    CPC分类号： A61K31/7088 ,  A61K9/1272 ,  A61K31/711 ,  A61K31/7125 ,  A61K39/39 ,  A61K2039/55555 ,  A61K2039/55561 ,  C12N2310/18

    摘要： Lipid-nucleic acid particles can provide therapeutic benefits, even when the nucleic acid is not complementary to coding sequences in target cells. It has been found that lipid-nucleic acid particles, including those containing non-sequence specific oligodeoxynucleotides, can be used to stimulate cytokine secretion, thus enhancing the overall immune response of a treated mammal. Further, immune response to specific target antigens can be induced by administration of an antigenic molecule in association with lipid particles containing non-sequence specific oligodeoxynucleotides. The nucleic acid which is included in the lipid-nucleic acid particle can be a phosphodiester (i.e., an oligodeoxynucleotide consisting of nucleotide residues joined by phosphodiester linkages) or a modified nucleic acid which includes phosphorothioate or other modified linkages, and may suitably be one which is non-complementary to the human genome, such that it acts to provide immunostimulation in a manner which is independent of conventional base-pairing interactions between the nucleic acid and nucleic acids of the treated mammal. In particular, the nucleic acid may suitably contain an immune-stimulating motif such as a CpG motif, or an immune stimulating palindromic sequence. The cationic lipid included in the nucleic acid particles may be suitably selected from among DODAP, DODMA, DMDMA, DOTAP, DC-Chol, DDAB, DODAC, DMRIE, DOSPA and DOGS. In addition, the lipid particle may suitably contain a modified aggregation-limiting lipid such as a PEG-lipid, a PAO-lipid or a ganglioside.