公开(公告)号：EP0917534B1

公开(公告)日：2002-12-04

申请号：EP97929071.5

申请日：1997-07-11

申请人： Inflazyme Pharmaceuticals, Ltd. ,  THE UNIVERSITY OF BRITISH COLUMBIA ,  UNIVERSITY OF ALBERTA

发明人： BURGOYNE, David, L. ,  SHEN, Yaping ,  LANGLANDS, John, M. ,  ROGERS, Christine ,  CHAU, Joseph, H.-L. ,  PIERS, Edward ,  SALARI, Hassan

IPC分类号： C07J1/00 ,  C07J51/00 ,  C07J17/00 ,  A61K31/56 ,  C07J71/00 ,  C07J21/00

CPC分类号： C07J9/00 ,  C07J1/0007 ,  C07J1/0011 ,  C07J1/0022 ,  C07J3/00 ,  C07J7/002 ,  C07J13/005 ,  C07J13/007 ,  C07J17/00 ,  C07J21/008 ,  C07J31/006 ,  C07J41/0016 ,  C07J51/00 ,  C07J71/001 ,  C07J71/0026 ,  Y02P20/55 ,  Y10S514/825 ,  Y10S514/826

摘要： Steroid compounds having various oxygen substitution on the steroid nucleus are disclosed. A specific functionality present on many of the steroid compounds is oxygen substitution at both of positions 6 and 7. Thus, certain steroids have oxygen substitution at C6 and C7, and some have specific stereochemistries such as 6 alpha and 7 beta oxygen substitution, and an alpha hydrogen at the 5 position in addition to having 6 alpha and 7 beta oxygen substitution. Steroids having 3,4-epoxy functionality are also disclosed. In addition, steroids having C17 pyran and delta -lactone functionality, with oxygen substitution at C6 and C7, or at C15, of the steroid nucleus, are disclosed.

公开(公告)号：EP0917534A2

公开(公告)日：1999-05-26

申请号：EP97929071.0

申请日：1997-07-11

申请人： Inflazyme Pharmaceuticals, Ltd. ,  THE UNIVERSITY OF BRITISH COLUMBIA ,  UNIVERSITY OF ALBERTA

发明人： BURGOYNE, David, L. ,  SHEN, Yaping ,  LANGLANDS, John, M. ,  ROGERS, Christine ,  CHAU, Joseph, H.-L. ,  PIERS, Edward ,  SALARI, Hassan

IPC分类号： A61K31 ,  C07J1 ,  C07J3 ,  C07J7 ,  C07J9 ,  C07J13 ,  C07J17 ,  C07J21 ,  C07J31 ,  C07J41 ,  C07J51 ,  C07J71

CPC分类号： C07J9/00 ,  C07J1/0007 ,  C07J1/0011 ,  C07J1/0022 ,  C07J3/00 ,  C07J7/002 ,  C07J13/005 ,  C07J13/007 ,  C07J17/00 ,  C07J21/008 ,  C07J31/006 ,  C07J41/0016 ,  C07J51/00 ,  C07J71/001 ,  C07J71/0026 ,  Y02P20/55 ,  Y10S514/825 ,  Y10S514/826

摘要： Steroid compounds having various oxygen substitution on the steroid nucleus are disclosed. A specific functionality present on many of the steroid compounds is oxygen substitution at both of positions 6 and 7. Thus, certain steroids have oxygen substitution at C6 and C7, and some have specific stereochemistries such as 6α and 7β oxygen substitution, and an alpha hydrogen at the 5 position in addition to having 6α and 7β oxygen substitution. Steroids having 3,4-epoxy functionality are also disclosed. In addition, steroids having C17 pyran and δ-lactone functionality, with oxygen substitution at C6 and C7, or at C15, of the steroid nucleus, are disclosed.