公开(公告)号：EP1304333A2

公开(公告)日：2003-04-23

申请号：EP02025269.8

申请日：1997-07-11

申请人： Inflazyme Pharmaceuticals, Ltd. ,  THE UNIVERSITY OF BRITISH COLUMBIA ,  UNIVERSITY OF ALBERTA

发明人： Piers, Edward ,  Chau, Joseph, H.L ,  Rogers, Christine ,  Salari, Hassan ,  Burgoyne, David, L. ,  Shen, Yaping ,  Langlands, John, M.

IPC分类号： C07J1/00 ,  C07J51/00 ,  C07J17/00 ,  A61K31/56 ,  C07J71/00 ,  C07J21/00

CPC分类号： C07J71/001 ,  C07J1/0007 ,  C07J1/0011 ,  C07J1/0022 ,  C07J3/00 ,  C07J7/002 ,  C07J9/00 ,  C07J13/005 ,  C07J13/007 ,  C07J17/00 ,  C07J21/008 ,  C07J31/006 ,  C07J41/0016 ,  C07J51/00 ,  C07J71/0026

摘要： Steroid compounds having various oxygen substitution on the steroid nucleus are disclosed. A specific functionality present on many of the steroid compounds is oxygen substitution at both of positions 6 and 7. Thus, certain steroids have oxygen substitution at C6 and C7, and some have specific stereochemistries such as 6α and 7β oxygen substitution, and an alpha hydrogen at the 5 position in addition to having 6α and 7β oxygen substitution. Steroids having 3,4-epoxy functionality are also disclosed. In addition, steroids having C17 pyran and δ-lactone functionality, with oxygen substitution at C6 and C7, or at C15, of the steroid nucleus, are disclosed.

摘要翻译： 公开了在类固醇核上具有各种氧取代的类固醇化合物。 存在于许多类固醇化合物上的具体功能是在6和7位都是氧取代。因此，某些类固醇在C6和C7具有氧取代，并且一些具有特异性立体化学例如6α和7β氧取代， 除了具有6个α和7个β氧取代之外，在5位的α氢。 还公开了具有3,4-环氧官能团的类固醇。 此外，公开了具有C17吡喃和δ-内酯官能团的类固醇，其在类固醇核的C6和C7或C15处具有氧取代。

公开(公告)号：EP1304333A3

公开(公告)日：2005-03-09

申请号：EP02025269.8

申请日：1997-07-11

申请人： Inflazyme Pharmaceuticals, Ltd. ,  THE UNIVERSITY OF BRITISH COLUMBIA ,  UNIVERSITY OF ALBERTA

发明人： Piers, Edward ,  Chau, Joseph, H.L ,  Rogers, Christine ,  Salari, Hassan ,  Burgoyne, David, L. ,  Shen, Yaping ,  Langlands, John, M.

IPC分类号： C07J1/00 ,  A61K31/56 ,  C07J21/00 ,  C07J51/00 ,  C07J71/00 ,  C07J17/00 ,  C07J13/00 ,  C07J9/00 ,  C07J7/00 ,  C07J3/00 ,  C07J31/00 ,  C07J41/00

CPC分类号： C07J71/001 ,  C07J1/0007 ,  C07J1/0011 ,  C07J1/0022 ,  C07J3/00 ,  C07J7/002 ,  C07J9/00 ,  C07J13/005 ,  C07J13/007 ,  C07J17/00 ,  C07J21/008 ,  C07J31/006 ,  C07J41/0016 ,  C07J51/00 ,  C07J71/0026

摘要： Steroid compounds having various oxygen substitution on the steroid nucleus are disclosed. A specific functionality present on many of the steroid compounds is oxygen substitution at both of positions 6 and 7. Thus, certain steroids have oxygen substitution at C6 and C7, and some have specific stereochemistries such as 6α and 7β oxygen substitution, and an alpha hydrogen at the 5 position in addition to having 6α and 7β oxygen substitution. Steroids having 3,4-epoxy functionality are also disclosed. In addition, steroids having C17 pyran and δ-lactone functionality, with oxygen substitution at C6 and C7, or at C15, of the steroid nucleus, are disclosed.