公开(公告)号：EP1355928B1

公开(公告)日：2007-05-16

申请号：EP02700240.1

申请日：2002-02-01

申请人： Institut Curie ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  Institut National de la Santé et de la Recherche Médicale ,  Université Pierre et Marie Curie (Paris VI)

发明人： JOHANNES, Ludger ,  TARTOUR, Eric ,  GOUD, Bruno ,  FRIDMAN, Wolf, Hervé

IPC分类号： C07K14/25 ,  C07K19/00 ,  C07K17/00 ,  C12N15/31 ,  C12N1/21 ,  C12Q1/68 ,  A61K48/00 ,  A61K38/16

CPC分类号： A61K39/385 ,  A61K38/00 ,  A61K48/00 ,  A61K2039/6037 ,  A61K2039/627 ,  C07K14/25 ,  C07K2319/00

摘要： The present invention concerns an universal polypeptidic carrier for targeting directly or indirectly a molecule to Gb3 receptor expressing cells and having the following formula STxB-Z(n)-Cys, wherein: STxB is the Shiga Toxin B subunit or a functional equivalent thereof, Z is an amino-acid devoided of sulfydryl group, n being 0, 1 or a polypeptide, Cys is the amino-acid Cysteine. p

公开(公告)号：EP1355928A1

公开(公告)日：2003-10-29

申请号：EP02700240.1

申请日：2002-02-01

申请人： Institut Curie ,  Centre National De La Recherche Scientifique ,  Institut National de la Santé et de la Recherche Medicale ,  Université Pierre et Marie Curie (Paris VI)

发明人： JOHANNES, Ludger ,  TARTOUR, Eric ,  GOUD, Bruno ,  FRIDMAN, Wolf, Hervé

IPC分类号： C07K14/25 ,  C07K19/00 ,  C07K17/00 ,  C12N15/31 ,  C12N1/21 ,  C12Q1/68 ,  A61K48/00 ,  A61K38/16

CPC分类号： A61K39/385 ,  A61K38/00 ,  A61K48/00 ,  A61K2039/6037 ,  A61K2039/627 ,  C07K14/25 ,  C07K2319/00

摘要： The present invention concerns an universal polypeptidic carrier for targeting directly or indirectly a molecule to Gb3 receptor expressing cells and having the following formula STxB-Z(n)-Cys, wherein: STxB is the Shiga Toxin B subunit or a functional equivalent thereof, Z is an amino-acid devoided of sulfydryl group, n being 0, 1 or a polypeptide, Cys is the amino-acid Cysteine. p

公开(公告)号：EP1017715B1

公开(公告)日：2008-05-28

申请号：EP98939705.4

申请日：1998-07-17

申请人： Institut Curie ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

发明人： GOUD, Bruno ,  JOHANNES, Ludger

IPC分类号： C12N15/11 ,  C07K14/25 ,  C07K14/245 ,  C07K14/47 ,  C07K14/705 ,  A61K38/04 ,  C12N15/62

CPC分类号： C07K14/4748 ,  A61K38/00 ,  A61K39/0011 ,  A61K2039/53 ,  A61K2039/572 ,  C07K14/245 ,  C07K14/25 ,  C07K14/4712 ,  C07K14/705 ,  C07K2319/00 ,  C07K2319/40 ,  C07K2319/55

摘要： The invention concerns a polypeptide sequence comprising the fragment B of Shiga toxin or a functional equivalent thereof bound at the carboxy-terminal end with one or several polypeptides corresponding to the formula B - X in which B represents the fragment B of the Shiga toxin and X represents one or several polypeptides of therapeutic interest, and its use as active principle in a therapeutic composition.

公开(公告)号：EP2734978A1

公开(公告)日：2014-05-28

申请号：EP12740124.8

申请日：2012-07-19

申请人： Institut Curie ,  Centre National de la Recherche Scientifique (CNRS)

发明人： SCHAUER, Kristine ,  DUONG, Thanh Buu ,  GOUD, Bruno

IPC分类号： G06T7/00 ,  G06T7/20

CPC分类号： G06K9/00147 ,  B65D81/264 ,  B65D85/76 ,  G06T7/0016 ,  G06T7/277 ,  G06T2207/30004

摘要： The present invention relates to a method of processing data for comparing at least two images using data processing means. A first sample of coordinate values (X
1 ,...,X
n1 ) is extracted (100) from at least one first image (Im1) and a second sample of coordinate values (Y
1 ,...,Y
n2 ) is extracted (100) from at least one second image (Im2). A normal score value (Z) is then computed (200), with the processing means, based on a density test statistic function (
T ) applied on the first and second samples of coordinate values, wherein this density test statistic function has an asymptotic distribution, and a p-value, derived from the computed normal score value (Z), is compared (400) with a predetermined level of significance (α) in order to determine a similarity between the two images. Such a method can be used for example for determining the influence of a compound on a biological structure, monitoring a drug treatment comprising one or more specific treatment compound(s), assessing the cytotoxicity of a predetermined compound on a biological structure, determining cellular morphology changes due to modifications in the expression level of cellular constituents, determining the influence of a infection by pathogens or detecting morphological changes in a biological structure over time.

摘要翻译： 处理数据的使用数据处理元件比较至少两个图像的方法，包括：提取的坐标值的第一样本（X1，...，XN1）从至少一个第一图像（Im1的）和坐标值的第二样品（ Y1，...，Y N2）从至少一个第二图像（I M2）。 然后，正常得分值（Z）的计算，与处理元件，基于施加于坐标值的第一和第二样品的密度检验统计函数（[数（T）}），worin此密度检验统计函数具有 到为了渐近分布，以及p值，从所计算的标准值的分数（Z）衍生的，相比较（400）具有显着性（α）的预定水平确定性矿两个图像之间的相似性。 该方法可用于确定开采的影响和离开唱化合物，药物治疗监控的，确定性的采矿细胞形态的变化和感染的病原体的影响的细胞毒性。

公开(公告)号：EP1017715A2

公开(公告)日：2000-07-12

申请号：EP98939705.4

申请日：1998-07-17

申请人： Institut Curie ,  CENTRE NATIONAL DELA RECHERCHE SCIENTIFIQUE

发明人： GOUD, Bruno ,  JOHANNES, Ludger

IPC分类号： C07K14/00

CPC分类号： C07K14/4748 ,  A61K38/00 ,  A61K39/0011 ,  A61K2039/53 ,  A61K2039/572 ,  C07K14/245 ,  C07K14/25 ,  C07K14/4712 ,  C07K14/705 ,  C07K2319/00 ,  C07K2319/40 ,  C07K2319/55

摘要： The invention concerns a polypeptide sequence comprising the fragment B of Shiga toxin or a functional equivalent thereof bound at the carboxy-terminal end with one or several polypeptides corresponding to the formula B - X in which B represents the fragment B of the Shiga toxin and X represents one or several polypeptides of therapeutic interest, and its use as active principle in a therapeutic composition.

摘要翻译： 本发明涉及使用下式的嵌合多肽的方法：B-X其中B代表志贺毒素的B片段或其功能等同物，X代表一种或多种具有治疗意义的多肽。 也包括含多肽B-X的用于治疗用途的组合物。