专利检索 ap:("Institut Curie" OR "INSERM (Institut National de la Santé et de la Recherche Médicale)") AND inv:"MANEL, Nicolas" 第 1 页

1.

发明公开
MYELOID CELLS OVEREXPRESSING BCL2 审中-实审

公开(公告)号：EP4346912A1

公开(公告)日：2024-04-10

申请号：EP22730822.8

申请日：2022-05-25

申请人： Institut Curie , INSERM (Institut National de la Santé et de la Recherche Médicale)

发明人： MANEL, Nicolas , LAHAYE, Xavier , FUENTEALBA, Jaime , SAITAKIS, Michael , AMIGORENA, Sebastian

IPC分类号： A61K48/00 , C07K14/47 , C07K14/725 , C12N5/0784 , A61K35/17 , A61K39/00 , C12N15/10 , C12N15/86

2.

发明公开
METHOD TO MONITOR AND QUANTIFY INTERPHASE NUCLEAR ENVELOPE RUPTURE EVENTS 审中-公开

公开(公告)号：EP3417287A1

公开(公告)日：2018-12-26

申请号：EP17705642.1

申请日：2017-02-17

申请人： Institut Curie , INSERM (Institut National de la Santé et de la Recherche Médicale) , Centre National de la Recherche Scientifique

发明人： PIEL, Matthieu , GENTILI, Matteo , RAAB, Matthew , MANEL, Nicolas

IPC分类号： G01N33/50 , G01N33/569

CPC分类号： G01N33/5035 , G01N33/56966 , G01N2333/9125

摘要： The present invention provides an in vitro method for monitoring interphase nuclear envelope rupture events in a eukaryotic cell or screening or identifying compound capable of increasing or decreasing the intensity and/or frequency of interphase nuclear envelope rupture events in a eukaryotic cell. These methods relate on a protein having a cytosolic non-nuclear localization in interphase and a non-sequence specific DNA binding activity. Interphase nuclear envelope rupture events are characterized by the presence of the protein of the invention in the nucleus of the eukaryotic cell.

3.

发明授权
METHOD FOR PREPARING VIRAL PARTICLES WITH CYCLIC DINUCLEOTIDE AND USE OF SAID PARTICLES FOR TREATING CANCER 有权

公开(公告)号：EP3430147B1

公开(公告)日：2020-09-09

申请号：EP16710729.1

申请日：2016-03-16

申请人： Institut Curie , INSERM (Institut National de la Santé et de la Recherche Médicale)

发明人： MANEL, Nicolas , GENTILI, Matteo , SATOH, Takeshi , REHWINKEL, Jan , BRIDGEMAN, Anne , DAVENNE, Tamara , MAELFAIT, Jonathan

IPC分类号： C12N15/86 , A61K9/51 , A61K31/7084 , A61P35/00

4.

发明公开
METHOD FOR PREPARING VIRAL PARTICLES WITH CYCLIC DINUCLEOTIDE AND USE OF SAID PARTICLES FOR TREATING CANCER 审中-公开

公开(公告)号：EP3770265A1

公开(公告)日：2021-01-27

申请号：EP20193607.7

申请日：2016-03-16

申请人： Institut Curie , Institut National de la Santé et de la Recherche Médicale

发明人： MANEL, Nicolas , GENTILI, Matteo , SATOH, Takeshi , REHWINKEL, Jan , BRIDGEMAN, Anne , DAVENNE, Tamara , MAELFAIT, Jonathan

IPC分类号： C12N15/86 , A61K9/51 , A61K31/7084 , A61K45/06 , A61K47/02 , A61P35/00 , A61K9/00

摘要： The present invention relates to methods for preparing virus-like particles comprising immunogenic cyclic dinucleotides and its use for treating cancer.

5.

发明公开
COMPOSITIONS AND METHODS FOR USE IN IMMUNOTHERAPY 审中-公开

公开(公告)号：EP4326769A1

公开(公告)日：2024-02-28

申请号：EP22723448.1

申请日：2022-04-20

申请人： Institut Curie , Institut National de la Santé et de la Recherche Médicale (INSERM) , Stimunity

发明人： MANEL, Nicolas , JNEID, Bakhos

IPC分类号： C07K16/28 , A61K31/00 , A61K39/395 , A61P35/00 , A61K31/7084 , A61K31/506

6.

发明公开
COMPOSITIONS AND METHODS FOR USE IN IMMUNOTHERAPY 审中-公开

公开(公告)号：EP4326321A1

公开(公告)日：2024-02-28

申请号：EP22720734.7

申请日：2022-04-20

申请人： Institut Curie , Institut National de la Santé et de la Recherche Médicale (INSERM) , Stimunity

发明人： MANEL, Nicolas , JNEID, Bakhos

IPC分类号： A61K39/395 , A61K38/16 , A61K31/7125 , A61P35/00 , A61P37/02