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公开(公告)号：EP4440570A1
公开(公告)日：2024-10-09
申请号：EP22826074.1
申请日：2022-11-30
申请人： Institut National de la Santé et de la Recherche Médicale (INSERM) , APHP (Assistance Publique - Hôpitaux de Paris) , Fondation Imagine , Université Paris Cité , Centre National de la Recherche Scientifique
发明人： HERMINE, Olivier , WEIMERSHAUS, Mirjana , TROVATI MACIEL, Thiago , VAN ENDERT, Peter , DUSSIOT, Michael , RIGNAULT-BRICARD, Rachel , CARVALHO, Caroline
IPC分类号： A61K31/352 , A61P29/00
CPC分类号： A61K31/352 , A61P29/00 , A61K31/351 , A61K31/55 , A61K31/4709 , A61K31/713 , A61K31/395
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2.发明公开
公开(公告)号：EP3980012A1
公开(公告)日：2022-04-13
申请号：EP20728803.6
申请日：2020-06-03
申请人： Institut National de la Santé et de la Recherche Médicale (INSERM) , Université de Paris , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) , Assistance Publique-Hôpitaux de Paris (APHP) , Fondation Imagine , Conservatoire National des Arts et Métiers (CNAM)
发明人： LEPELLETIER, Yves , MONTES, Matthieu , DEMANGE, Luc , RAYNAUD, Françoise , RIGNAULT-BRICARD, Rachel , HERMINE, Olivier , LOPEZ, Nicolas
IPC分类号： A61K31/4184 , A61K31/437 , A61P35/00 , A61K45/06
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3.发明公开
公开(公告)号：EP4240761A1
公开(公告)日：2023-09-13
申请号：EP21802725.8
申请日：2021-11-04
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公开(公告)号：EP4065224A1
公开(公告)日：2022-10-05
申请号：EP20811388.6
申请日：2020-11-27
申请人： Institut National de la Santé et de la Recherche Médicale (INSERM) , Fondation Imagine , Assistance Publique-Hôpitaux de Paris (APHP) , Université de Paris Cité
IPC分类号： A61P15/00 , A61K38/18 , A61K39/395 , A61K31/4184
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5.发明公开
公开(公告)号：EP4059569A1
公开(公告)日：2022-09-21
申请号：EP22157031.0
申请日：2020-01-02
申请人： INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , Assistance Publique-Hôpitaux de Paris , Fondation Imagine , Centre national de la recherche scientifique , Université de Paris , Université Paris-Saclay
发明人： HERMINE, Olivier , ROSSIGNOL, Julien , BELAID-CHOUCAIR, Zakia , FOUQUET, Guillemette , COURONNE, Lucile , DUSSIOT, Michael , RIGNAULT-BRICARD, Rachel , COMAN, Tereza , GUILLEM, Flavia , LEPELLETIER, Yves , RENAND, Amédée , MILPIED, Pierre
IPC分类号： A61P35/00 , C07K16/28 , G01N33/574
摘要： Targeting immune checkpoints, such as Programmed cell Death 1 (PD1), has improved survival in cancer patients by unleashing exhausted CD8+ T-cell thereby restoring anti-tumor immune responses. Most patients, however, relapse or are refractory to immune checkpoint blocking therapies. Here, the inventors show that NRP1 is recruited in the cytolytic synapse of PD1+CD8+ T-cells, interacts and enhances PD-1 activity. In mice, CD8+ T-cell specific deletion of Nrp1 improves spontaneous and anti PD1 antibody anti-tumor immune responses. Likewise, in human metastatic melanoma, the expression of NRP1 in tumor infiltrating CD8+ T-cells predicts poor outcome of patients treated with anti-PDl (e.g. pembrolizumab). Finally, the combination of anti-NRPl and anti-PDl antibodies is synergistic in human, specifically in CD8+ T -cells anti-tumor response. Thus the therapeutic inhibition of NRP1 alone or combined with an immune checkpoint inhibitor (e.g. anti-PDl antibody) could efficiently repress tumor growth in human cancer. The present invention also relates to multispecific antibodies comprising at least one binding site that specifically binds to an immune checkpoint molecule (e.g. PD-1), and at least one binding site that specifically binds to NRP-1. The present invention also relates to a population of cells engineered to express a chimeric antigen receptor (CAR) and wherein the expression of NRP-1 in said cells is repressed.
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6.发明公开
公开(公告)号：EP3906415A1
公开(公告)日：2021-11-10
申请号：EP20700002.7
申请日：2020-01-02
申请人： INSERM (Institut National de la Santé et de la Recherche Médicale) , Assistance Publique-Hôpitaux de Paris (APHP) , Fondation Imagine , Université Paris Descartes , Centre National de la Recherche Scientifique (CNRS) , Université Paris-Saclay
发明人： HERMINE, Olivier , ROSSIGNOL, Julien , BELAID-CHOUCAIR, Zakia , FOUQUET, Guillemette , COURONNE, Lucile , DUSSIOT, Michael , RIGNAULT-BRICARD, Rachel , COMAN, Tereza , GUILLEM, Flavia , LEPELLETIER, Yves , RENAND, Amédée , MILPIED, Pierre
IPC分类号： G01N33/574
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公开(公告)号：EP4061371A1
公开(公告)日：2022-09-28
申请号：EP20807791.7
申请日：2020-11-20
申请人： AB Science , Université Paris Cité , ASSISTANCE PUBLIQUE HOPITAUX DE PARIS , Institut National de la Santé et de la Recherche Médicale , Imagine Institut des Maladies Génétiques Necker Enfants Malades
发明人： MOUSSY, Alain , KINET, Jean-Pierre , HERMINE, Olivier , TROVATI MACIEL, Thiago , ALLALI, Slimane , RIGNAULT-BRICARD, Rachel , CARVALHO, Caroline
IPC分类号： A61K31/496 , A61P7/06 , A61P11/00
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