-
1.发明公开METHODS AND PHARMACEUTICAL COMPOSITIONS FOR THE CARDIOPROTECTION 有权VERFAHREN UND PHARMAZEUTISCHE ZUSAMMENSETZUNGEN ZUR KARDIOPROTEKTION
公开(公告)号：EP2943212A1
公开(公告)日：2015-11-18
申请号：EP14700845.2
申请日：2014-01-14
申请人： Institut National de la Santé et de la Recherche Médicale (INSERM) , UNIVERSITE DE MONTPELLIER , Université Montpellier 2, Sciences et Techniques , Assistance Publique Hôpitaux De Paris , Université d'Angers , Université Paris-Est Créteil Val de Marne
发明人： LACAMPAGNE, Alain , THIREAU, Jérôme , CAZORLA, Olivier , LE GUENNEC, Jean-Yves , FAUCONNIER, Jérémy , MARTINEZ, Maria Del Carmen , ANDRIANTSITOHAINA, Ramaroson , GALEH-MARZBAN, Bijan , SOLETI, Raffaella
CPC分类号： A61K38/1709 , A61K9/0019 , A61K9/16 , A61P9/06 , A61P9/10 , C07K14/47 , C07K14/4705 , C07K2319/30
摘要： The present invention relates to methods and pharmaceutical compositions for cardioprotection of subjects who experienced a myocardial infarction. In particular, the present invention relates to a ligand of the sonic hedgehog signaling pathway for use in the cardioprotection of a subject who experienced a myocardial infarction.
摘要翻译： 本发明涉及心脏保护用于经历心肌梗塞的受试者的方法和药物组合物。 特别地，本发明涉及用于经历心肌梗塞的受试者的心脏保护的声音刺猬蛋白信号传导途径的配体。
-
公开(公告)号：EP2943212B8
公开(公告)日：2018-05-16
申请号：EP14700845.2
申请日：2014-01-14
申请人： Institut National de la Santé et de la Recherche Médicale (INSERM) , UNIVERSITE DE MONTPELLIER , Assistance Publique Hôpitaux De Paris , Université d'Angers , Université Paris-Est Créteil Val de Marne
发明人： LACAMPAGNE, Alain , THIREAU, Jérôme , CAZORLA, Olivier , LE GUENNEC, Jean-Yves , FAUCONNIER, Jérémy , MARTINEZ, Maria Del Carmen , ANDRIANTSITOHAINA, Ramaroson , GALEH-MARZBAN, Bijan , SOLETI, Raffaella
CPC分类号： A61K38/1709 , A61K9/0019 , A61K9/16 , A61P9/06 , A61P9/10 , C07K14/47 , C07K14/4705 , C07K2319/30
摘要： The present invention relates to methods and pharmaceutical compositions for cardioprotection of subjects who experienced a myocardial infarction. In particular, the present invention relates to a ligand of the sonic hedgehog signaling pathway for use in the cardioprotection of a subject who experienced a myocardial infarction.
-
公开(公告)号：EP2943212B1
公开(公告)日：2018-03-28
申请号：EP14700845.2
申请日：2014-01-14
申请人： Institut National de la Santé et de la Recherche Médicale (INSERM) , UNIVERSITE DE MONTPELLIER , Université Montpellier 2, Sciences et Techniques , Assistance Publique Hôpitaux De Paris , Université d'Angers , Université Paris-Est Créteil Val de Marne
发明人： LACAMPAGNE, Alain , THIREAU, Jérôme , CAZORLA, Olivier , LE GUENNEC, Jean-Yves , FAUCONNIER, Jérémy , MARTINEZ, Maria Del Carmen , ANDRIANTSITOHAINA, Ramaroson , GALEH-MARZBAN, Bijan , SOLETI, Raffaella
CPC分类号： A61K38/1709 , A61K9/0019 , A61K9/16 , A61P9/06 , A61P9/10 , C07K14/47 , C07K14/4705 , C07K2319/30
摘要： The present invention relates to methods and pharmaceutical compositions for cardioprotection of subjects who experienced a myocardial infarction. In particular, the present invention relates to a ligand of the sonic hedgehog signaling pathway for use in the cardioprotection of a subject who experienced a myocardial infarction.
-
4.发明公开CASPASE INHIBITORS FOR TREATING PATHOLOGIES RESULTING FROM ISCHEMIA 审中-公开半胱氨酸蛋白酶抑制剂用于PATHOLOGIES缺血的治疗
公开(公告)号：EP2173384A2
公开(公告)日：2010-04-14
申请号：EP08776545.9
申请日：2008-06-27
申请人： CHIESI FARMACEUTICI S.p.A. , Institut National de la Santé et de la Recherche Médicale (INSERM)
CPC分类号： C07K7/02 , A61K47/545 , A61K47/58 , A61K47/60 , A61K47/645
摘要： The inventors have studied the kinetic and hierarchy of activation of apoptogenic caspases during myocardial ischemia and have found that caspase 2 plays a major role during the cardiac pathology by a very fast activation after an ischemic episode. Experiments were carried out on animal models of transitory or permanent myocardial ischemia. It was then observed that electrophysiological remodeling and post-ischemic fibrosis were prevented by using caspase-2 specific inhibitors. The invention is then based on the demonstration that caspase-2 and its activation represents an early and transitory step of the cardiac apoptotic mechanisms resulting from a myocardial ischemic and involved in the development of hypertrophy and cardiac insufficiency. The invention thus relates to a method of treatment of cardiovascular pathologies resulting from ischemia by using certain caspase-2 specific inhibitors.
-
-
-
搜索结果
4 条记录 (耗时 0.025 秒)
