公开(公告)号：EP1865320A3

公开(公告)日：2008-02-20

申请号：EP07252322.8

申请日：2007-06-08

申请人： Institut Pasteur Korea

发明人： Emans, Neil ,  Altschuler, Yoram ,  Kwon, Yongjun

IPC分类号： G01N33/50 ,  G01N33/74 ,  C07K14/705

CPC分类号： G01N33/5035 ,  G01N33/5008 ,  G01N33/566 ,  G01N2333/5754 ,  G01N2333/70571 ,  G01N2333/726 ,  G01N2800/12 ,  G01N2800/32

摘要： A method for identifying a compound that modifies the cellular distribution of a GPCR in a population of cells comprising:
a) taking a population of cells expressing a GPCR
b) incubating said cells with a candidate compound and with a ligand of the GPCR
c) determining distribution of said GPCR in cells treated according to step b) and comparing with distribution of GPCR in cells incubated with a ligand of the GPCR in the absence of the candidate compound;

wherein altered distribution in cells incubated with the candidate compound is indicative that the candidate compound modifies GPCR cellular distribution.