公开(公告)号：EP2581376A1

公开(公告)日：2013-04-17

申请号：EP11774274.2

申请日：2011-04-29

申请人： Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences

发明人： JIANG, Jiandong ,  SONG, Danqing ,  DU, Nana ,  PENG, Zonggen ,  WANG, Yuping ,  GAO, Limei ,  HAN, Yanxing ,  LI, Xin ,  LI, Chunxin

IPC分类号： C07D471/16 ,  C07D471/22 ,  A61K31/4375 ,  A61P31/14

CPC分类号： C07D471/16 ,  C07D471/22

摘要： The present invention relates to a N-substituted matrinic acid derivative or matrine derivative, and its preparation method and uses. Specifically, the present invention relates to a compound of Formula (I) or (II) (wherein all the definitions of substituted groups are those mentioned in the specification), or a pharmaceutically acceptable salt, geometric isomer, stereoisomer, solvate, ester or prodrug thereof. The present invention further relates to a method for preparing the compound of the present invention, a pharmaceutical composition containing the compound, and uses thereof in manufacture of a medicament. The compound of the present invention can be used for prophylaxis and/or treatment of a disease or disorder associated with viral infection such as hepatitis B and/orhepatitis C and/orAIDS.

摘要翻译： N-取代的甘草酸衍生物或苦参碱衍生物及其制备方法和用途。 具体而言，本发明涉及式（I）或（II）的化合物（其中所有取代基的定义均为说明书中提及的那些），或其药学上可接受的盐，几何异构体，立体异构体，溶剂化物，酯或前药 它们。 本发明进一步涉及制备本发明化合物的方法，含有该化合物的药物组合物及其在制备药物中的用途。 本发明的化合物可以用于预防和/或治疗与病毒感染有关的疾病或病症，例如乙型和/或丙型肝炎和/或艾滋病。

公开(公告)号：EP2253621A1

公开(公告)日：2010-11-24

申请号：EP09703551.3

申请日：2009-01-19

申请人： Institute Of Medicinal Biotechnology, Chinese Academy of Medical Sciences

发明人： LI, Zhuorong ,  PENG, Zonggen ,  LI, Yanping ,  ZHU, Jianhua ,  TAO, Peizhen ,  FAN, Bo ,  WANG, Yuping ,  SHAN, Guangzhi ,  WANG, Shuqin ,  ZHANG, Tian ,  JIANG, Jiandong

IPC分类号： C07D225/06 ,  C07H19/06 ,  C07D401/12 ,  A61K31/395 ,  A61K31/4427 ,  A61P31/12 ,  A61P35/00

CPC分类号： C07D225/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07H19/067

摘要： A set of geldanamycin derivatives and their preparation methods. Pharmaceutical compositions comprising the said compounds as an active ingredient which are used as antivirus and antitumor agents. The said derivatives are used in the manufacture of heat shock protein 90(Hsp 90) inhibiting agents which have the utility as antivirus and antitumor agents.

摘要翻译： 一组格尔德霉素衍生物及其制备方法。 药物组合物，其包含所述化合物作为活性成分，用作抗病毒剂和抗肿瘤剂。 所述衍生物用于制造具有抗病毒和抗肿瘤剂作用的热休克蛋白90（Hsp90）抑制剂。