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1.发明公开A SET OF GELDANAMYCIN DERIVATIVES AND THEIR PREPARATION METHODS 审中-公开VERFAHREN ZU IHRER HERSTELLUNG的EINE GRUPPE VON GELDANAMYCINDERIVATEN
公开(公告)号：EP2253621A1
公开(公告)日：2010-11-24
申请号：EP09703551.3
申请日：2009-01-19
发明人： LI, Zhuorong , PENG, Zonggen , LI, Yanping , ZHU, Jianhua , TAO, Peizhen , FAN, Bo , WANG, Yuping , SHAN, Guangzhi , WANG, Shuqin , ZHANG, Tian , JIANG, Jiandong
IPC分类号： C07D225/06 , C07H19/06 , C07D401/12 , A61K31/395 , A61K31/4427 , A61P31/12 , A61P35/00
CPC分类号： C07D225/06 , C07D401/12 , C07D401/14 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07H19/067
摘要： A set of geldanamycin derivatives and their preparation methods. Pharmaceutical compositions comprising the said compounds as an active ingredient which are used as antivirus and antitumor agents. The said derivatives are used in the manufacture of heat shock protein 90(Hsp 90) inhibiting agents which have the utility as antivirus and antitumor agents.
摘要翻译： 一组格尔德霉素衍生物及其制备方法。 药物组合物，其包含所述化合物作为活性成分，用作抗病毒剂和抗肿瘤剂。 所述衍生物用于制造具有抗病毒和抗肿瘤剂作用的热休克蛋白90（Hsp90）抑制剂。
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2.发明授权A GROUP OF AMINO SUBSTITUTED BENZOYL DERIVATIVES AND THEIR PREPARATION AND THEIR USE 有权GROUP氨基取代的苯甲酰基和其生产和使用
公开(公告)号：EP2351731B1
公开(公告)日：2016-02-10
申请号：EP09817185.3
申请日：2009-09-28
发明人： JIANG, Jiandong , YU, Liyan , CEN, Shan , LI, Zhuorong , LI, Yanping , XU, Jian
IPC分类号： C07C237/44 , C07C309/76 , C07C311/46 , A61K31/167 , A61K31/16 , A61P31/12 , C07C327/28 , C07D207/36 , C07D213/75 , C07D239/47 , C07D239/52 , C07D307/66 , C07C233/43 , C07C233/54 , C07C255/57 , C07C229/60
CPC分类号： C07C327/28 , C07C229/60 , C07C233/25 , C07C233/33 , C07C233/43 , C07C233/54 , C07C237/42 , C07C237/44 , C07C255/57 , C07C309/76 , C07C311/08 , C07C311/29 , C07C311/44 , C07C311/46 , C07D207/36 , C07D213/75 , C07D239/42 , C07D239/47 , C07D239/52 , C07D307/66
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3.发明公开A GROUP OF AMINO SUBSTITUTED BENZOYL DERIVATIVES AND THEIR PREPARATION AND THEIR USE 有权DEREN VERWENDUNG DEREN HERSTELLUNG的GRUPPE AMINOSUTITUIERTER BENZOYLDERIVATE
公开(公告)号：EP2351731A1
公开(公告)日：2011-08-03
申请号：EP09817185.3
申请日：2009-09-28
发明人： JIANG, Jiandong , YU, Liyan , CEN, Shan , LI, Zhuorong , LI, Yanping , XU, Jian
IPC分类号： C07C237/44 , C07C233/12 , C07C229/54 , C07C327/16 , C07C307/02 , C07C303/26 , C07D239/52 , A61K31/21 , A61K31/165 , A61K31/255 , A61P31/12
CPC分类号： C07C327/28 , C07C229/60 , C07C233/25 , C07C233/33 , C07C233/43 , C07C233/54 , C07C237/42 , C07C237/44 , C07C255/57 , C07C309/76 , C07C311/08 , C07C311/29 , C07C311/44 , C07C311/46 , C07D207/36 , C07D213/75 , C07D239/42 , C07D239/47 , C07D239/52 , C07D307/66
摘要： A group of amino substituted benzoyl derivatives, their preparation and their use. The screening and research on an antiviral drug with hA3G/Vif as a target point proves that the 3-amino benzoyl derivatives not only have the combined activity for the hA3G/Vif, but also have a function of inhibiting replication of viruses. The present invention provides the possible breakthrough progress for the problem of HIV drug resistance, thereby providing a novel clinical antiviral drug which has higher efficiency.
摘要翻译： 一组氨基取代的苯甲酰基衍生物，其制备及其用途。 以hA3G / Vif为靶点的抗病毒药物的筛选和研究证明，3-氨基苯甲酰基衍生物不仅具有hA3G / Vif的组合活性，而且具有抑制病毒复制的功能。 本发明提供了HIV耐药性问题可能的突破性进展，从而提供了具有更高效率的新型临床抗病毒药物。
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公开(公告)号：EP3339287A1
公开(公告)日：2018-06-27
申请号：EP16836341.4
申请日：2016-08-17
发明人： LI, Yanping , LI, Zhuorong , PENG, Zonggen , LI, Jianrui , JIANG, Xinbei , CHEN, Jinhua , JIANG, Jiandong
IPC分类号： C07C255/50 , C07D213/84 , C07D241/04 , A61K31/44 , A61K31/495 , A61P31/14 , A61P31/20
CPC分类号： C07C255/50 , A61P31/16 , C07C255/58 , C07D211/56 , C07D213/85 , C07D241/04 , C07D295/13 , C07D295/155 , C07D401/04
摘要： Provided are a new aromatic cyanogen compound and a preparation method thereof. The present invention also relates to the use of such compound in antiviral drugs, in particular the use thereof in anti-HCV drugs.
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