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1.发明授权JOINT PRODUCT CONTAINING PHENTERMINE AND TOPIRAMATE AND PREPARATION METHOD THEREFOR 有权随着产品芬特明和托吡酯及其制造方法CONNECTION
公开(公告)号：EP2829266B1
公开(公告)日：2016-11-30
申请号：EP13763543.9
申请日：2013-03-20
发明人： LI, Song , GAO, Chunsheng , ZHONG, Wu , WANG, Yuli , YANG, Meiyan , SHAN, Li , ZHOU, Xinbo , ZHENG, Zhibing , WANG, Xiaokui
IPC分类号： A61K9/16 , A61K9/52 , A61K31/35 , A61K31/357 , A61K9/50 , A61K9/48 , A61K31/137
CPC分类号： A61K31/357 , A61K9/4808 , A61K9/5047 , A61K9/5078 , A61K9/5084 , A61K9/5089 , A61K31/137 , A61K2300/00
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公开(公告)号：EP2829270B1
公开(公告)日：2020-11-11
申请号：EP13764754.1
申请日：2013-03-22
发明人： LI, Song , GAO, Chunsheng , ZHONG, Wu , WANG, Yuli , YANG, Meiyan , SHAN, Li , ZHOU, Xinbo , ZHENG, Zhibing , WANG, Xiaokui
IPC分类号： A61K31/357 , A61K31/137 , A61K9/30 , A61K9/16 , A61P3/04 , A61K9/50
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3.发明授权
公开(公告)号：EP2829267B1
公开(公告)日：2020-05-06
申请号：EP13763714.6
申请日：2013-03-07
发明人： LI, Song , GAO, Chunsheng , ZHONG, Wu , WANG, Yuli , YANG, Meiyan , SHAN, Li , ZHOU, Xinbo , ZHENG, Zhibing , WANG, Xiaokui
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4.发明公开TOPIRAMATE SUSTAINED-RELEASE PHARMACEUTICAL COMPOSITION, METHOD FOR PREPARING SAME, AND USE THEREOF 审中-公开制药TOPIRAMATZUSAMMENSETZUNG缓释方法其生产及其用途
公开(公告)号：EP2829267A1
公开(公告)日：2015-01-28
申请号：EP13763714.6
申请日：2013-03-07
发明人： LI, Song , GAO, Chunsheng , ZHONG, Wu , WANG, Yuli , YANG, Meiyan , SHAN, Li , ZHOU, Xinbo , ZHENG, Zhibing , WANG, Xiaokui
IPC分类号： A61K9/22 , A61K31/7048 , A61K47/38 , A61K47/32 , A61P25/06 , A61P25/08 , A61P3/10 , A61P25/00 , A61P25/24 , A61P25/18 , A61P9/12
CPC分类号： A61K31/357 , A61K9/1676 , A61K9/5026 , A61K9/5042 , A61K9/5078 , A61K9/5089 , A61K31/7048
摘要： A sustained-release pharmaceutical composition of topiramate, which is free of binding agent. The sustained-release pharmaceutical composition of topiramate is a sustained-release pellet, comprising a blank pellet core, a drug layer, and a sustained-release coating layer.
摘要翻译： 托吡酯的缓释药物组合物，所有这些都可以自由结合剂。 托吡酯的缓释药物组合物是持续释放球粒，其包含空白丸芯，药物层和缓释包衣层。
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5.发明公开JOINT PRODUCT CONTAINING PHENTERMINE AND TOPIRAMATE AND PREPARATION METHOD THEREFOR 有权含有中间体和TOPIMAMATE的联合产品及其制备方法
公开(公告)号：EP2829266A1
公开(公告)日：2015-01-28
申请号：EP13763543.9
申请日：2013-03-20
发明人： LI, Song , GAO, Chunsheng , ZHONG, Wu , WANG, Yuli , YANG, Meiyan , SHAN, Li , ZHOU, Xinbo , ZHENG, Zhibing , WANG, Xiaokui
IPC分类号： A61K9/16 , A61K9/52 , A61K31/35 , A61K31/357
CPC分类号： A61K31/357 , A61K9/4808 , A61K9/5047 , A61K9/5078 , A61K9/5084 , A61K9/5089 , A61K31/137 , A61K2300/00
摘要： The present invention provides a combination product, which comprises immediate release pellet of phentermine and sustained-release pellet of topiramate, wherein the pellet of topiramate includes: a) a blank pellet core; b) an active drug layer that contains topiramate and is free of binding agent, the layer being located on surface of the blank pellet core; c) a sustained-release coating layer containing ethyl cellulose and PVP K30, the sustained-release coating layer being located on external of the active drug layer. The present invention further discloses a method for preparing the combination product.
摘要翻译： 本发明提供一种组合产品，其包含苯丁胺和托吡酯缓释小丸的速释小丸，其中托吡酯小丸包括：a）空白小丸芯; b）含有托吡酯且不含结合剂的活性药物层，所述层位于空白丸芯的表面上; c）含有乙基纤维素和PVP K30的缓释包衣层，缓释包衣层位于活性药物层的外部。 本发明还公开了一种制备组合产品的方法。
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公开(公告)号：EP2829270A1
公开(公告)日：2015-01-28
申请号：EP13764754.1
申请日：2013-03-22
发明人： LI, Song , GAO, Chunsheng , ZHONG, Wu , WANG, Yuli , YANG, Meiyan , SHAN, Li , ZHOU, Xinbo , ZHENG, Zhibing , WANG, Xiaokui
IPC分类号： A61K31/357 , A61K31/137 , A61K9/30 , A61K9/16 , A61P3/04
摘要： The present invention provides a joint product comprising synephrine and topiramate, in which the synephrine or salt thereof is administered in form of rapid-release preparation, preferably rapid-release pellet, having daily dose of 2mg to 25mg, preferably 5mg to 20mg; the topiramate is administered in form of sustained-release or controlled-release preparation, preferably sustained-release pellet, having daily dose of 20mg to 100mg, preferably 23mg to 92mg. The composition is used for treatment of obesity or other diseases associated with obesity.
摘要翻译： 本发明提供了含有辛弗林和托吡酯的联合产品，其中辛弗林或其盐以快速释放制剂形式给药，优选快速释放小丸，其日剂量为2mg至25mg，优选5mg至20mg; 托吡酯以缓释或控释制剂的形式给药，优选缓释小丸，其每日剂量为20mg至100mg，优选23mg至92mg。 该组合物用于治疗肥胖或其他与肥胖有关的疾病。
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