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1.发明公开PYRIDAZINE DERIVATIVES AND USE THEREOF AS MEDICAMENTS FOR TREATING MICRORNA VIRAL INFECTION 有权哒嗪和它们作为药物的微RNA病毒感染的治疗
公开(公告)号：EP2602252A1
公开(公告)日：2013-06-12
申请号：EP11814093.8
申请日：2011-08-02
发明人： LI, Song , WANG, Hongliang , XIAO, Junhai , ZHANG, Xian , WANG, Lili , ZHENG, Zhibing , ZHONG, Wu , XIE, Yunde , LI, Xingzhou , ZHOU, Xinbo , ZHAO, Guoming , WANG, Xiaokui
IPC分类号： C07D401/04 , A61K31/501 , A61P31/16
CPC分类号： C07D237/20
摘要： Disclosed are pyridazine derivatives represented by formula I or pharmaceutically acceptable salts or hydrates thereof, pharmaceutical compositions comprising the compounds, and the use of the compounds in preparing the medicaments for treating and/or preventing diseases or disorders associated with viral infections. The compounds represented by formula I have antiviral activity, especially anti-microRNA viral activity. Symbols in the compounds represented are described in the specification.
摘要翻译： 本发明公开了哒嗪衍生物由式I或其药学上可接受的盐或它们的水合物，药物组合物包含所述化合物，和在制备药物用于治疗和/或预防与病毒感染相关的疾病或病症中使用的化合物。 由式I化合物具有抗病毒活性，尤其是爱抗病毒微小RNA活性。 符号所表示的化合物中的描述在说明书中。
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公开(公告)号：EP3381910A1
公开(公告)日：2018-10-03
申请号：EP16867999.1
申请日：2016-11-24
发明人： LI, Song , XIAO, Junhai , XU, Libao , CAO, Ruiyuan , CAO, Fangyuan , WANG, Hongliang , ZHONG, Wu , ZHENG, Zhibing , XIE, Yunde , LI, Xingzhou , ZHOU, Xinbo , WANG, Xiaokui
IPC分类号： C07D277/52 , A61K31/426 , A61P31/12 , A61P31/16 , A61P11/04 , A61P1/16 , A61P31/18 , A61P31/14
CPC分类号： A61K31/426 , C07D277/52 , Y02A50/465
摘要： The present invention relates to a compound represented by Formula I, a racemate or optical isomer thereof, or a pharmaceutically acceptable salt, a solvate or a hydrate thereof, a pharmaceutical composition comprising the compound, and a use thereof in the manufacture of a medicament for preventing and/or treating a disease or disorder associated with a viral infection.
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3.发明授权THIAZOLAMINE DERIVATIVE AND USE THEREOF AS ANTI-PICORNAVIRAL INFECTION MEDICAMENT 有权THIAZOLAMINDERIVAT及其作为药物的用途反对小核糖核酸病毒感染
公开(公告)号：EP2650292B1
公开(公告)日：2015-08-26
申请号：EP11847007.9
申请日：2011-12-06
发明人： LI, Song , WANG, Hongliang , XIAO, Junhai , ZHANG, Xian , WANG, Lili , ZHENG, Zhibing , ZHONG, Wu , XIE, Yunde , LI, Xingzhou , ZHOU, Xinbo , ZHAO, Guoming , WANG, Xiaokui
IPC分类号： C07D417/04 , A61K31/496 , A61P31/14 , A61P31/16
CPC分类号： C07D417/04 , A61K31/496 , C07D277/42 , Y02A50/465
摘要： Disclosed is as a substituted thiazolamine derivative represented by Formula I or a pharmaceutically acceptable salt thereof or a hydrate thereof (the definitions of each group in the formula are as presented in the description), and the application thereof in the prevention and/or treatment of viral diseases induced by picornavirus. Also disclosed is a pharmaceutical composition containing the compound.
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公开(公告)号：EP3424913A1
公开(公告)日：2019-01-09
申请号：EP17759268.0
申请日：2017-03-02
发明人： LI, Song , XIAO, Junhai , ZHANG, Xiaoye , WANG, Hongliang , ZHONG, Wu , ZHENG, Zhibing , XIE, Yunde , LI, Xingzhou , ZHOU, Xinbo , WANG, Xiaokui
IPC分类号： C07D303/48 , C07D301/00 , C07D405/12 , A61K31/336 , A61K31/4523 , A61K31/4025 , A61K31/5377 , A61K31/541 , A61K31/427 , A61P35/00
摘要： The present invention relates to a 2,3-epoxy succinyl derivative, a preparation method and a use thereof, in particular, the present invention relates to a compound represented by Formula (1), a racemate or an optical isomer thereof, a solvate thereof, or a pharmaceutically acceptable salt thereof. The compound according to the present invention has good inhibitory activity and/or selectivity against cathepsin, especially Cathepsin B, can be used in the treatment of multiple diseases associated with cathepsin, for example, osteoporosis, rheumatoid arthritis and osteoarthritis that are associated with Cathepsin K, Ebola virus infection, a degenerative disease and an autoimmune disease that are associated with Cathepsin L, S, especially Cathepsin B-related tumor diseases, such as gastric cancer, cervical cancer, lung cancer, breast cancer, prostate cancer, bladder cancer, colon cancer, neuroglioma, and melanoma.
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5.发明授权PYRIDAZINE DERIVATIVES AND USE THEREOF AS MEDICAMENTS FOR TREATING MICRORNA VIRAL INFECTION 有权哒嗪和它们作为药物的微RNA病毒感染的治疗
公开(公告)号：EP2602252B1
公开(公告)日：2016-05-04
申请号：EP11814093.8
申请日：2011-08-02
发明人： LI, Song , WANG, Hongliang , XIAO, Junhai , ZHANG, Xian , WANG, Lili , ZHENG, Zhibing , ZHONG, Wu , XIE, Yunde , LI, Xingzhou , ZHOU, Xinbo , ZHAO, Guoming , WANG, Xiaokui
IPC分类号： C07D401/04 , A61K31/501 , A61P31/16
CPC分类号： C07D237/20
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