-
1.发明公开USE OF A MIR172 MOLECULE FOR DECREASING INFLAMMATION 审中-公开VERWENDUNG EINES MIR172-MOLEKÜLSZUR LINDERUNG VONENTZÜNDUNGEN
公开(公告)号：EP3035941A1
公开(公告)日：2016-06-29
申请号：EP14766010.4
申请日：2014-08-13
发明人： LUKASIK, Anna , ZIELENKIEWICZ, Piotr , SZWEYKOWSKA-KULINSKA, Zofia , PACZEK, Leszek , NOWACZYK, Maria
IPC分类号： A61K31/7088 , C12N15/113
CPC分类号： C12N15/113 , C12N2310/141
摘要： An exemplary embodiment relates to a method of using a plant-derived miR172 molecule or its synthetic equivalent, selected from amongst miR172a or miR172b, for decreasing inflammatory processes in an organism, a method of decreasing B and T lymphocyte proliferation, as well as a method of reducing protein FAN (Factor Associated with Neutral Sphingomyelinase Activation) level. Exemplary embodiments provide a novel therapeutic method based on miRNA molecules, which through the interaction with mRNA encoding FAN protein, negatively regulate its expression and decrease the inflammatory response of the organism.
摘要翻译： 示例性实施方案涉及使用植物来源的miR172分子或其选自miR172a或miR172b的合成等价物以减少生物体内炎症过程的方法，降低B和T淋巴细胞增殖的方法，以及方法 的降低蛋白质FAN（与中性鞘磷脂酶激活相关的因子）水平。 示例性实施方案提供了基于miRNA分子的新型治疗方法，其通过与编码FAN蛋白的mRNA的相互作用负调节其表达并降低生物体的炎症反应。
-
公开(公告)号：EP3035941B1
公开(公告)日：2018-10-03
申请号：EP14766010.4
申请日：2014-08-13
发明人： LUKASIK, Anna , ZIELENKIEWICZ, Piotr , SZWEYKOWSKA-KULINSKA, Zofia , PACZEK, Leszek , NOWACZYK, Maria
IPC分类号： A61K31/7088 , C12N15/113
CPC分类号： C12N15/113 , C12N2310/141
摘要： An exemplary embodiment relates to a method of using a plant-derived miR172 molecule or its synthetic equivalent, selected from amongst miR172a or miR172b, for decreasing inflammatory processes in an organism, a method of decreasing B and T lymphocyte proliferation, as well as a method of reducing protein FAN (Factor Associated with Neutral Sphingomyelinase Activation) level. Exemplary embodiments provide a novel therapeutic method based on miRNA molecules, which through the interaction with mRNA encoding FAN protein, negatively regulate its expression and decrease the inflammatory response of the organism.
-
3.发明授权COMPOUNDS AS MODULATORS OF A MUTANT CFTR PROTEIN AND THEIR USE FOR TREATING DISEASES ASSOCIATED WITH CFTR PROTEIN MALFUNCTION 有权化合物作为突变CFTR蛋白调制器和它们用于疾病治疗的蛋白质CFTR障碍有关
公开(公告)号：EP2616444B1
公开(公告)日：2015-08-26
申请号：EP11736202.0
申请日：2011-06-20
发明人： ODOLCZYK, Norbert , ZIELENKIEWICZ, Piotr , WIECZOREK, Grzegorz , EDELMAN, Aleksander , TONDELIER, Danielle , FRITSCH, Janine
IPC分类号： C07D219/10 , C07D473/30 , C07F9/30 , C07C233/65 , A61K31/663 , A61K31/435 , C07D401/12 , C07D473/22 , C07C235/84
CPC分类号： A61K31/194 , A61K31/496 , A61K31/52 , A61K31/663 , C07C233/65 , C07C235/84 , C07C2603/18 , C07D219/10 , C07D401/12 , C07D473/22 , C07D473/30 , C07F9/304 , C07F9/305
-
-
搜索结果
3 条记录 (耗时 0.011 秒)
