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1.发明公开MODIFIED GENE OF HUMAN ACTIVATION-INDUCED CYTIDINE DEAMINASE (AID), A METHOD OF MODIFICATION OF HUMAN AID GENE, A COMPOSITION SHOWING AID ACTIVITY, A METHOD OF PREPARATION OF SUCH COMPOSITION IN A BACTERIAL SYSTEM AND USE OF THE COMPOSITION IN THE ANALYSES OF DNA/RNA AMINATION/DEAMINATION AND/OR METHYLATION/DEMETHYLATION 有权人活化诱导的胞苷脱氨酶（AID），METHOD FOR MODIFICATION HUMAN AID-GEN，WITH AID活性，方法用于制造这样的组合物中中DNA / RNA胺化分析细菌系统和组合物的使用组成部分的修饰的基因/ - 脱氨和/或甲基化/去甲基化
公开(公告)号：EP2870241A1
公开(公告)日：2015-05-13
申请号：EP14703938.2
申请日：2014-01-14
CPC分类号： C12Q1/6827 , C07K2319/21 , C07K2319/23 , C07K2319/50 , C12N9/78 , C12Y305/04005
摘要： The subject of the invention is a modified gene of human activation-induced cytidine deaminase (AID), a method of modification of human AID gene, a composition showing AID activity, and a method of preparation of such composition. In particular, the invention concerns a modified gene of human AID for the production of an active enzyme in a bacterial system and use of the composition in the analyses of DNA/RNA amination/deamination and/or methylation/demethylatiori.
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2.发明授权A COMPOSITION SHOWING ACTIVATION-INDUCED CYTIDINE DEAMINASE (AID) ACTIVITY, A METHOD OF PREPARATION OF SUCH COMPOSITION IN A BACTERIAL SYSTEM AND USE OF THE COMPOSITION IN THE ANALYSES OF DNA/RNA AMINATION/DEAMINATION AND/OR METHYLATION/DEMETHYLATION 有权显示活化诱导的细胞色素脱氨酶（辅助）活性的组合物，细菌系统中这种组合物的制备方法以及组合物用于DNA / RNA氨化/脱氨和/或甲基化/二甲基化分析中的用途
公开(公告)号：EP2870241B1
公开(公告)日：2018-03-14
申请号：EP14703938.2
申请日：2014-01-14
CPC分类号： C12Q1/6827 , C07K2319/21 , C07K2319/23 , C07K2319/50 , C12N9/78 , C12Y305/04005
摘要： The subject of the invention is a modified gene of human activation-induced cytidine deaminase (AID), a method of modification of human AID gene, a composition showing AID activity, and a method of preparation of such composition. In particular, the invention concerns a modified gene of human AID for the production of an active enzyme in a bacterial system and use of the composition in the analyses of DNA/RNA amination/deamination and/or methylation/demethylatiori.
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