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公开(公告)号：EP2223249B1
公开(公告)日：2019-11-06
申请号：EP08851398.1
申请日：2008-11-25
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2.发明授权PEPTIDE WITH THE ENZYMATIC ACTIVITY OF A DICER-LIKE PROTEIN, A METHOD FOR PREPARING SHORT RNA MOLECULES, AND USE THEREOF 有权具有类似蛋白质的蛋白质的酶活性的肽，制备短RNA分子的方法及其用途
公开(公告)号：EP2726619B1
公开(公告)日：2017-12-20
申请号：EP12738654.8
申请日：2012-06-25
发明人： FIGLEROWICZ, Marek , TWORAK, Aleksander , PODKOWINSKI, Jan , KORALEWSKA, Natalia , KURZYNSKA-KOKORNIAK, Anna
IPC分类号： C12N15/82
CPC分类号： C12N9/22 , C12N15/8218 , C12P19/34
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3.发明公开NUCLEIC ACID MOLECULE, EXPRESSION CASSETTE, EXPRESSION VECTOR, EUKARYOTIC HOST CELL, INDUCTION METHOD OF RNA INTERFERENCE IN EUKARYOTIC HOST AND USE OF NUCLEIC ACID MOLECULE IN THERAPY OF DISEASES INDUCED BY EXPANSION OF TRINUCLEOTIDE CAG REPEATS 审中-公开核酸分子的表达盒，表达载体的真核宿主细胞，真核宿主RNA干扰的方法和使用分子NUCLEIC IN THERAPY OF因膨胀三核苷酸CAG重复INITIATED病杂志
公开(公告)号：EP3041936A2
公开(公告)日：2016-07-13
申请号：EP14781962.7
申请日：2014-09-02
IPC分类号： C12N15/113 , A61K31/713 , C12N5/10
CPC分类号： C12N15/113 , C12N2310/141 , C12N2310/334 , C12N2310/335 , C12N2310/336 , C12N2310/531 , C12N2310/533 , C12N2320/34 , C12N2330/51 , C12N2310/14
摘要： Subjects of the invention are: nucleic acid molecule, expression cassette, expression vector, eukaryotic host cell, induction method of RNA interference in eukaryotic host and use of nucleic acid molecule in therapy of diseases induced by expansion of trinucleotide CAG-type repeats. Solution relates to the new concept of treating hereditary human neurological diseases caused by expansion of CAG-type trinucleotide repeats using RNA interference technology.
摘要翻译： 本发明的主题是：核酸分子，表达盒，表达载体，真核宿主细胞，在真核宿主中和的诱导三核苷酸扩张CAG重复类型的疾病治疗中的用途的核酸分子的RNA干扰的诱导方法。 溶液涉及人的治疗通过使用RNA干扰技术CAG三核苷酸重复型的膨胀引起的遗传性神经系统疾病的新概念。
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4.发明公开A CYTOSINE ANALOGUE, A METHOD OF PREPARATION OF A CYTOSINE ANALOGUE, A DNA METHYLTRANSFERASE 1 INHIBITOR, A METHOD FOR DNA METHYLATION INHIBITION, THE USE OF THE ANALOGUE IN THE TREATMENT OF DISEASES ASSOCIATED WITH DEVIATIONS FROM NORMAL DNA METHYLATION 审中-公开胞嘧啶类似物，PROCESS FOR受到与正常DNA甲基化变异产生胞嘧啶类似物，DNA甲基转移酶1抑制剂，METHODS FOR DNA甲基化抑制，使用疾病治疗的模拟
公开(公告)号：EP2556081A2
公开(公告)日：2013-02-13
申请号：EP11716084.6
申请日：2011-03-17
发明人： BARCISZEWSKI, Jan , MARKIEWICZ, Wojciech, T. , ADAMSKA, Ewelina , PLITTA, Beata , GIEL-PIETRASZUK, Malgorzata , WYSZKO, Eliza , MARKIEWICZ, Maria , FEDORUK-WYSZOMIRSKA, Agnieszka , KULINSKI, Tadeusz , CHMIELEWSKI, Marcin
IPC分类号： C07H19/073 , C07D405/12 , A61K31/7068 , A61P35/00 , C07D239/47 , C07D401/12
CPC分类号： C07H19/073 , C07D239/47 , C07D401/12 , C07D405/12
摘要： This invention provides a cytosine analogue, a method of preparation of a cytosine analogue, a DNA rhethyltransferase 1 inhibitor, a method for DNA methylation inhibition, the use of the analogue in the treatment of diseases associated with deviations from normal DNA methylation. More precisely, the invention relates to various derivatives of cytosine, as well as methods of preparation of mono- and multi- 1,4,5 and 6-substituted cytosines. In general, the solution relates to providing effective modulators of DNA methylation which could be used in prevention and treatment of diseases associated with DNA methylation level disorders.
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5.发明授权A SEQUENCE OF DSRNA: ATN-RNA, INTERVENTION USING IRNAI, USE OF A SEQUENCE OF DSRNA: ATN-RNA, A METHOD OF TREATING AND INHIBITING A BRAIN TUMOR, A KIT FOR INHIBITING CANCER CELL WHICH EXPRESSES TENASCIN, A METHOD FOR A KIT PREPARATION IN A BRAIN TUMOR THERAPY 有权的dsRNA：ATN-RNA序列，干预USING IRNAI，采用的dsRNA：ATN-RNA序列，METHOD用于治疗和抑制的脑肿瘤，KIT用于抑制肌腱蛋白表达癌细胞，METHOD FOR套件WITH A BRAIN CANCER THERAPY PRODUCTION
公开(公告)号：EP2121927B1
公开(公告)日：2012-10-10
申请号：EP07793958.5
申请日：2007-07-30
申请人： Instytut Chemii Bioorganicznej PAN , Bioinfobank Sp. Z O.O. , Uniwersytet Medyczny Im. Karola Marcinkowskiego
发明人： BARCISZEWSKI, Jan , BARCISZEWSKA, Miroslawa , RYCHLEWSKI, Leszek , WYSZKO, Eliza , GAWRONSKA, Iwona , ZUKIEL, Ryszard , ROLLE, Katarzyna , NOWAK, Stanisaw
IPC分类号： C12N15/113
CPC分类号： C12N15/1136 , C12N15/113 , C12N2310/14
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6.发明公开COMPUTER-BASED MODELING AND DESIGNING OF PHOSPHOFRUCTOKINASE 1 (PFK) MODULATORS 审中-公开计算机辅助设计您的建模和磷酸果糖激酶1调制器（PFK）
公开(公告)号：EP2232394A2
公开(公告)日：2010-09-29
申请号：EP08851787.5
申请日：2008-11-25
IPC分类号： G06F19/00
CPC分类号： G06F19/706 , C12N9/1205 , C12Y207/01011 , G06F19/16
摘要： The subject matters of the invention are: a crystallographic model of the binding site and a modulator regulating the catalytic activity of phosphofructokinase (PFK), a method of designing, selecting and producing a PFK modulator, a computer-based method for the analysis of the interaction between the modulator and PFK, a computer-based method the analysis of molecular structures, a method of assessing the ability of the potential modulator to interact in the binding site on the PFK surface, a method of providing data for generating structures and/or performing design for ligands binding PFK, PFK homologues or analogues, complexes of PFK with a potential modulator, or complexes of PFK homologues or analogues with potential modulators, a computer system. The invention makes it possible to design a suitable activator, which could be used to modulate PFK activity, taking advantage of PFKs capability to bind in its effector site phosphate groups or other groups with a similar potential to interact, which correspond with the substituents in positions 1, 2 and 6 of the fructose ring, or groups corresponding with positions of the fructose ring groups interacting in the PFK effector site.
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7.发明公开METHOD OF OBTAINING OF 4-N-FURFURYLCYTOSINE AND/OR ITS DERIVATIVES, AN ANTI-AGING COMPOSITION AND USE OF 4-N-FURFURYLCYTOSINE AND/OR ITS DERIVATIVES IN THE MANUFACTURE OF ANTI-AGING COMPOSITION 有权PROCESS FOR PRODUCING 4-N-FURFURYLCYTOSIN和/或它的衍生物，组合物AGAINST老化和4-N-FURFURYLCYTOSIN和/或它的衍生物用于生产抗老化A组合物
公开(公告)号：EP2225228A2
公开(公告)日：2010-09-08
申请号：EP08851400.5
申请日：2008-11-25
发明人： BARCISZEWSKI, Jan , MARKIEWICZ, Wojciech T. , WYSZKO, Eliza , MARKIEWICZ, Maria , NOWAK, Monika , ROLLE, Katarzyna , ADAMSKA, Ewelina , CHMIELEWSKI, Marcin, K.
IPC分类号： C07D405/12 , C07D405/14 , A61K8/49 , C07H19/167 , C07H19/173 , A61K31/513
CPC分类号： C07D405/12 , A61K8/49 , A61Q19/08 , C07D405/14
摘要： The subjects of the present invention are the method of preparation of 4-furfurylcytosine and/or its derivatives, its use in the manufacture of anti-aging compositions and an anti- aging composition. As 4-furfurylcytosine and/or its derivatives possesses a series of biological properties it might be use as a composition having excellent anti-aging effect to prevent the sagging of skin and loss of luster and to improve sufficiently its aesthetic appearance without significantly change the growth rate and the total growth ability of the skin. Optimal methods of manufacturing this compound, while at the same time obtaining the highest possible process efficiency, with particular emphasis on its utility in the pharmaceutical and cosmetic industries are presented.
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8.发明授权METHOD OF OBTAINING OF 4-N-FURFURYLCYTOSINE AND/OR ITS DERIVATIVES, AN ANTI-AGING COMPOSITION AND USE OF 4-N-FURFURYLCYTOSINE AND/OR ITS DERIVATIVES IN THE MANUFACTURE OF ANTI-AGING COMPOSITION 有权PROCESS FOR PRODUCING 4-N-FURFURYLCYTOSIN和/或它的衍生物，组合物AGAINST老化和4-N-FURFURYLCYTOSIN和/或它的衍生物用于生产抗老化A组合物
公开(公告)号：EP2225228B1
公开(公告)日：2016-10-12
申请号：EP08851400.5
申请日：2008-11-25
发明人： BARCISZEWSKI, Jan , MARKIEWICZ, Wojciech T. , WYSZKO, Eliza , MARKIEWICZ, Maria , NOWAK, Monika , ROLLE, Katarzyna , ADAMSKA, Ewelina , CHMIELEWSKI, Marcin, K.
IPC分类号： C07D405/12 , C07D405/14 , A61K8/49 , C07H19/167 , C07H19/173 , A61K31/513
CPC分类号： C07D405/12 , A61K8/49 , A61Q19/08 , C07D405/14
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9.发明公开MODIFIED GENE OF HUMAN ACTIVATION-INDUCED CYTIDINE DEAMINASE (AID), A METHOD OF MODIFICATION OF HUMAN AID GENE, A COMPOSITION SHOWING AID ACTIVITY, A METHOD OF PREPARATION OF SUCH COMPOSITION IN A BACTERIAL SYSTEM AND USE OF THE COMPOSITION IN THE ANALYSES OF DNA/RNA AMINATION/DEAMINATION AND/OR METHYLATION/DEMETHYLATION 有权人活化诱导的胞苷脱氨酶（AID），METHOD FOR MODIFICATION HUMAN AID-GEN，WITH AID活性，方法用于制造这样的组合物中中DNA / RNA胺化分析细菌系统和组合物的使用组成部分的修饰的基因/ - 脱氨和/或甲基化/去甲基化
公开(公告)号：EP2870241A1
公开(公告)日：2015-05-13
申请号：EP14703938.2
申请日：2014-01-14
CPC分类号： C12Q1/6827 , C07K2319/21 , C07K2319/23 , C07K2319/50 , C12N9/78 , C12Y305/04005
摘要： The subject of the invention is a modified gene of human activation-induced cytidine deaminase (AID), a method of modification of human AID gene, a composition showing AID activity, and a method of preparation of such composition. In particular, the invention concerns a modified gene of human AID for the production of an active enzyme in a bacterial system and use of the composition in the analyses of DNA/RNA amination/deamination and/or methylation/demethylatiori.
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10.发明公开AN RNA OLIGOMER, METHODS FOR REGULATING A MICRORNA PRODUCTION PROCESS AND RNA OLIGOMERS USED AS MICRORNA PRODUCTION PROCESS REGULATORS 审中-公开RNA低聚物的方法用于控制的微小RNA的生产工艺和作为使用RNA低聚物的microRNA调节器的方法
公开(公告)号：EP2817408A1
公开(公告)日：2014-12-31
申请号：EP13711481.5
申请日：2013-02-20
发明人： KURZYNSKA-KOKORNIAK, Anna , KORALEWSKA, Natalia , FIGLEROWICZ, Marek , TYCZEWSKA, Agata , TWARDOWSKI, Tomasz
IPC分类号： C12N15/115
CPC分类号： C12N15/115 , C12N2310/16
摘要： The present invention relates to an RNA oligomer, methods for regulating ' a miRNA production process and RNA oligomers used as miRNA production process regulators. More precisely, the present invention relates to use of RNA oligomers disrupting a pre-miRNA structure as miRNA production process regulators. Oligomer interactions with a miRNA precursor (pre-miRNA) change the precursor' s secondary and tertiary structure. In consequence, the pre-miRNA is not specifically recognised and cleaved by the Dicer ribonuclease, and the specific miRNA is not produced.
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