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1.发明授权PEPTIDE WITH THE ENZYMATIC ACTIVITY OF A DICER-LIKE PROTEIN, A METHOD FOR PREPARING SHORT RNA MOLECULES, AND USE THEREOF 有权具有类似蛋白质的蛋白质的酶活性的肽，制备短RNA分子的方法及其用途
公开(公告)号：EP2726619B1
公开(公告)日：2017-12-20
申请号：EP12738654.8
申请日：2012-06-25
发明人： FIGLEROWICZ, Marek , TWORAK, Aleksander , PODKOWINSKI, Jan , KORALEWSKA, Natalia , KURZYNSKA-KOKORNIAK, Anna
IPC分类号： C12N15/82
CPC分类号： C12N9/22 , C12N15/8218 , C12P19/34
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2.发明公开MODIFIED GENE OF HUMAN ACTIVATION-INDUCED CYTIDINE DEAMINASE (AID), A METHOD OF MODIFICATION OF HUMAN AID GENE, A COMPOSITION SHOWING AID ACTIVITY, A METHOD OF PREPARATION OF SUCH COMPOSITION IN A BACTERIAL SYSTEM AND USE OF THE COMPOSITION IN THE ANALYSES OF DNA/RNA AMINATION/DEAMINATION AND/OR METHYLATION/DEMETHYLATION 有权人活化诱导的胞苷脱氨酶（AID），METHOD FOR MODIFICATION HUMAN AID-GEN，WITH AID活性，方法用于制造这样的组合物中中DNA / RNA胺化分析细菌系统和组合物的使用组成部分的修饰的基因/ - 脱氨和/或甲基化/去甲基化
公开(公告)号：EP2870241A1
公开(公告)日：2015-05-13
申请号：EP14703938.2
申请日：2014-01-14
CPC分类号： C12Q1/6827 , C07K2319/21 , C07K2319/23 , C07K2319/50 , C12N9/78 , C12Y305/04005
摘要： The subject of the invention is a modified gene of human activation-induced cytidine deaminase (AID), a method of modification of human AID gene, a composition showing AID activity, and a method of preparation of such composition. In particular, the invention concerns a modified gene of human AID for the production of an active enzyme in a bacterial system and use of the composition in the analyses of DNA/RNA amination/deamination and/or methylation/demethylatiori.
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3.发明公开AN RNA OLIGOMER, METHODS FOR REGULATING A MICRORNA PRODUCTION PROCESS AND RNA OLIGOMERS USED AS MICRORNA PRODUCTION PROCESS REGULATORS 审中-公开RNA低聚物的方法用于控制的微小RNA的生产工艺和作为使用RNA低聚物的microRNA调节器的方法
公开(公告)号：EP2817408A1
公开(公告)日：2014-12-31
申请号：EP13711481.5
申请日：2013-02-20
发明人： KURZYNSKA-KOKORNIAK, Anna , KORALEWSKA, Natalia , FIGLEROWICZ, Marek , TYCZEWSKA, Agata , TWARDOWSKI, Tomasz
IPC分类号： C12N15/115
CPC分类号： C12N15/115 , C12N2310/16
摘要： The present invention relates to an RNA oligomer, methods for regulating ' a miRNA production process and RNA oligomers used as miRNA production process regulators. More precisely, the present invention relates to use of RNA oligomers disrupting a pre-miRNA structure as miRNA production process regulators. Oligomer interactions with a miRNA precursor (pre-miRNA) change the precursor' s secondary and tertiary structure. In consequence, the pre-miRNA is not specifically recognised and cleaved by the Dicer ribonuclease, and the specific miRNA is not produced.
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4.发明授权A COMPOSITION SHOWING ACTIVATION-INDUCED CYTIDINE DEAMINASE (AID) ACTIVITY, A METHOD OF PREPARATION OF SUCH COMPOSITION IN A BACTERIAL SYSTEM AND USE OF THE COMPOSITION IN THE ANALYSES OF DNA/RNA AMINATION/DEAMINATION AND/OR METHYLATION/DEMETHYLATION 有权显示活化诱导的细胞色素脱氨酶（辅助）活性的组合物，细菌系统中这种组合物的制备方法以及组合物用于DNA / RNA氨化/脱氨和/或甲基化/二甲基化分析中的用途
公开(公告)号：EP2870241B1
公开(公告)日：2018-03-14
申请号：EP14703938.2
申请日：2014-01-14
CPC分类号： C12Q1/6827 , C07K2319/21 , C07K2319/23 , C07K2319/50 , C12N9/78 , C12Y305/04005
摘要： The subject of the invention is a modified gene of human activation-induced cytidine deaminase (AID), a method of modification of human AID gene, a composition showing AID activity, and a method of preparation of such composition. In particular, the invention concerns a modified gene of human AID for the production of an active enzyme in a bacterial system and use of the composition in the analyses of DNA/RNA amination/deamination and/or methylation/demethylatiori.
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5.发明授权METHOD TO INHIBIT RIBONUCLEASE DICER, RIBONUCLEASE DICER INHIBITOR, AND USE OF RNA APTAMERS AS RIBONUCLEASE DICER INHIBITORS 有权于抑制核糖核酸酶Dicer酶，核糖核酸酶Dicer酶抑制剂和RNA适体核糖核酸酶Dicer酶的使用方法抑制剂
公开(公告)号：EP2255002B1
公开(公告)日：2014-04-02
申请号：EP09709670.5
申请日：2009-02-09
IPC分类号： C12N15/11
CPC分类号： C12N15/115 , C12N2310/141 , C12N2310/16
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公开(公告)号：EP2908852A1
公开(公告)日：2015-08-26
申请号：EP13795005.1
申请日：2013-10-21
CPC分类号： C07K14/43527 , A61K38/00 , A61K39/00 , A61K39/0003 , A61K39/0225 , A61K39/39 , A61K45/06 , C07K14/445 , C12N15/64 , C12N15/86 , Y02A50/401
摘要： The present invention relates to a Lyme disease vaccine, a genetic construct, recombinant protein, method for genetic construct design, method for vaccine delivery, method for recombinant proteins delivery, use of recombinant proteins in the production of Lyme disease vaccine. In particular, the method concerns the use of TROSPA and TROSPA-Salp15 recombinant proteins derived from castor bean tick (Ixodes riccinus) as a component of Lyme disease vaccine for animals. The antibodies present in blood of an immunized vertebrate directed against the TROSPA proteins considerably reduce the chance of infecting new ticks by blocking or hindering the interaction of TROSPA protein with OspA protein of Borrelia burgdorferi sensu lato. The interaction is crucial in the process of the spirochete entering a tick. The antibodies directed against the TROSPA-Salp15 protein protect vertebrates from infection on the stage of Borellia diffusion by destroying their protective coating formed at the surface as a result of the interaction between the Salp15 tick protein and OspC spirochete protein. The vaccine based on TROSPA tick proteins and TROSPA-Salp15 proteins may be used independently or together with the OspA recombinant proteins and OspC protein of Borrelia burgdorferi sensu lato.
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公开(公告)号：EP2908852B1
公开(公告)日：2017-06-14
申请号：EP13795005.1
申请日：2013-10-21
CPC分类号： C07K14/43527 , A61K38/00 , A61K39/00 , A61K39/0003 , A61K39/0225 , A61K39/39 , A61K45/06 , C07K14/445 , C12N15/64 , C12N15/86 , Y02A50/401
摘要： The present invention relates to a Lyme disease vaccine, a genetic construct, recombinant protein, method for genetic construct design, method for vaccine delivery, method for recombinant proteins delivery, use of recombinant proteins in the production of Lyme disease vaccine. In particular, the method concerns the use of TROSPA and TROSPA-Salp15 recombinant proteins derived from castor bean tick (Ixodes riccinus) as a component of Lyme disease vaccine for animals. The antibodies present in blood of an immunized vertebrate directed against the TROSPA proteins considerably reduce the chance of infecting new ticks by blocking or hindering the interaction of TROSPA protein with OspA protein of Borrelia burgdorferi sensu lato. The interaction is crucial in the process of the spirochete entering a tick. The antibodies directed against the TROSPA-Salp15 protein protect vertebrates from infection on the stage of Borellia diffusion by destroying their protective coating formed at the surface as a result of the interaction between the Salp15 tick protein and OspC spirochete protein. The vaccine based on TROSPA tick proteins and TROSPA-Salp15 proteins may be used independently or together with the OspA recombinant proteins and OspC protein of Borrelia burgdorferi sensu lato.
摘要翻译： 本发明涉及莱姆病疫苗，基因构建体，重组蛋白质，遗传构建体设计方法，疫苗递送方法，重组蛋白质递送方法，重组蛋白质在莱姆病疫苗生产中的应用。 具体而言，该方法涉及使用来自蓖麻蜱（Ixodes riccinus）的TROSPA和TROSPA-Salp15重组蛋白作为动物莱姆病疫苗的组分。 存在于针对TROSPA蛋白质的免疫脊椎动物的血液中的抗体通过阻断或阻碍TROSPA蛋白与伯氏疏螺旋体的OspA蛋白的相互作用而显着降低感染新蜱的机会。 在螺旋体进入蜱的过程中，相互作用是至关重要的。 由于Salp15蜱蛋白和OspC螺旋体蛋白之间的相互作用，针对TROSPA-Salp15蛋白的抗体通过破坏它们在表面形成的保护性涂层来保护脊椎动物免于在Borellia扩散阶段的感染。 基于TROSPA蜱蛋白和TROSPA-Salp15蛋白的疫苗可独立使用或与OspA重组蛋白和Borrelia burgdorferi sensu lato的OspC蛋白一起使用。
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8.发明公开PEPTIDE WITH THE ENZYMATIC ACTIVITY OF A DICER-LIKE PROTEIN, A METHOD FOR PREPARING SHORT RNA MOLECULES, AND USE THEREOF 有权WITH A Dicer酶蛋白的酶活性肽，用于生产短链RNA分子及其用途
公开(公告)号：EP2726619A1
公开(公告)日：2014-05-07
申请号：EP12738654.8
申请日：2012-06-25
发明人： FIGLEROWICZ, Marek , TWORAK, Aleksander , PODKOWINSKI, Jan , KORALEWSKA, Natalia , KURZYNSKA-KOKORNIAK, Anna
IPC分类号： C12N15/82
CPC分类号： C12N9/22 , C12N15/8218 , C12P19/34
摘要： The subject of the invention is a peptide with the enzymatic activity of a Dicer-like protein, a method for preparing short RNA molecules, and use thereof. The purpose of the solution was to develop a new method of producing short RNA molecules, using a new, MtDCLlpepA peptide of a Dicer protein activity designed by inventors.
摘要翻译： 在本发明的主题是具有切酶 - 样蛋白，用于制备短RNA分子的方法的酶活性的肽，以及它们的使用。 溶液什么开发生产短RNA分子，使用由发明人设计了一种切酶蛋白活性的一种新的，MtDCL1pepA肽的新方法的目的。
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9.发明公开METHOD TO INHIBIT RIBONUCLEASE DICER, RIBONUCLEASE DICER INHIBITOR, AND USE OF RNA APTAMERS AS RIBONUCLEASE DICER INHIBITORS 有权于抑制核糖核酸酶Dicer酶，核糖核酸酶Dicer酶抑制剂和RNA适体核糖核酸酶Dicer酶的使用方法抑制剂
公开(公告)号：EP2255002A2
公开(公告)日：2010-12-01
申请号：EP09709670.5
申请日：2009-02-09
IPC分类号： C12N15/11
CPC分类号： C12N15/115 , C12N2310/141 , C12N2310/16
摘要： The subject of the present invention is a method to inhibit ribonuclease Dicer, ribonuclease Dicer inhibitor, and use of RNA aptamers to inhibit ribonuclease Dicer. More specifically, this solution relates to using RNA aptamers as ribonuclease Dicer inhibitors that acts upon the competition basis (aptamers as competence inhibitors), use of RNA aptamers as allosteric ribonuclease Dicer inhibitors, and use of RNA aptamers as selective inhibitors of emergence of the selected miRNAs.
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