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1.发明公开A CYTOSINE ANALOGUE, A METHOD OF PREPARATION OF A CYTOSINE ANALOGUE, A DNA METHYLTRANSFERASE 1 INHIBITOR, A METHOD FOR DNA METHYLATION INHIBITION, THE USE OF THE ANALOGUE IN THE TREATMENT OF DISEASES ASSOCIATED WITH DEVIATIONS FROM NORMAL DNA METHYLATION 审中-公开胞嘧啶类似物，PROCESS FOR受到与正常DNA甲基化变异产生胞嘧啶类似物，DNA甲基转移酶1抑制剂，METHODS FOR DNA甲基化抑制，使用疾病治疗的模拟
公开(公告)号：EP2556081A2
公开(公告)日：2013-02-13
申请号：EP11716084.6
申请日：2011-03-17
发明人： BARCISZEWSKI, Jan , MARKIEWICZ, Wojciech, T. , ADAMSKA, Ewelina , PLITTA, Beata , GIEL-PIETRASZUK, Malgorzata , WYSZKO, Eliza , MARKIEWICZ, Maria , FEDORUK-WYSZOMIRSKA, Agnieszka , KULINSKI, Tadeusz , CHMIELEWSKI, Marcin
IPC分类号： C07H19/073 , C07D405/12 , A61K31/7068 , A61P35/00 , C07D239/47 , C07D401/12
CPC分类号： C07H19/073 , C07D239/47 , C07D401/12 , C07D405/12
摘要： This invention provides a cytosine analogue, a method of preparation of a cytosine analogue, a DNA rhethyltransferase 1 inhibitor, a method for DNA methylation inhibition, the use of the analogue in the treatment of diseases associated with deviations from normal DNA methylation. More precisely, the invention relates to various derivatives of cytosine, as well as methods of preparation of mono- and multi- 1,4,5 and 6-substituted cytosines. In general, the solution relates to providing effective modulators of DNA methylation which could be used in prevention and treatment of diseases associated with DNA methylation level disorders.
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