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公开(公告)号：EP3389670A1
公开(公告)日：2018-10-24
申请号：EP16871732.0
申请日：2016-12-05
发明人： SPECTOR, David, L. , DIERMEIER, Sarah, Daniela , RIGO, Frank , BENNETT, C., Frank , FREIER, Susan, M. , ARUN, Gayatri , CHANG, Kung-chi
IPC分类号： A61K31/7088 , A61P35/00 , C12N15/11 , C12N15/113
CPC分类号： A61K31/713 , A61K45/06 , C12N15/113 , C12N2310/113 , C12N2310/315 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , A61K2300/00 , C12N2310/321 , C12N2310/3525
摘要： Provided herein are methods, compounds, and compositions for reducing expression of a MaTAR in an animal. Such methods, compounds, and compositions are useful to treat, prevent, delay, or ameliorate breast cancer in an individual in need.
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公开(公告)号：EP3548620A1
公开(公告)日：2019-10-09
申请号：EP17877203.4
申请日：2017-12-01
发明人： YU, Allen, Tingjin , SPECTOR, David, L. , RIGO, Frank , FREIER, Susan, M. , BERMANN, Jan , BERASAIN, Carmen
IPC分类号： C12N15/113 , C12N15/11
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公开(公告)号：EP4402260A1
公开(公告)日：2024-07-24
申请号：EP22870970.5
申请日：2022-09-16
发明人： FREIER, Susan, M. , BUI, Huynh-Hoa
IPC分类号： C12N15/11 , A61K31/7088 , A61K31/712 , A61K31/7125 , C07H21/00
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公开(公告)号：EP4396351A1
公开(公告)日：2024-07-10
申请号：EP22865773.0
申请日：2022-08-31
发明人： RIGO, Frank , SWAYZE, Eric, E. , JAFAR-NEJAD, Paymaan , OESTERGAARD, Michael , LING, Kar, Yun Karen , FREIER, Susan, M. , BUI, Huynh-Hoa
IPC分类号： C12N15/113 , A61K31/7125 , A61K9/00
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公开(公告)号：EP4294406A1
公开(公告)日：2023-12-27
申请号：EP22756940.7
申请日：2022-02-17
发明人： FREIER, Susan, M. , BUI, Huynh-Hoa
IPC分类号： A61K31/7088 , C12N15/113 , A61P13/12 , A61K48/00
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公开(公告)号：EP3978610A2
公开(公告)日：2022-04-06
申请号：EP21187734.5
申请日：2015-03-19
发明人： FREIER, Susan, M. , HUNG, Gene , BENNETT, C. Frank
IPC分类号： C12N15/113
摘要： Disclosed herein are antisense compounds and methods for decreasing Ataxin 2 mRNA and protein expression. Such methods, compounds, and compositions are useful to treat, prevent, or ameliorate Ataxin 2 associated diseases, disorders, and conditions. Such Ataxin 2 associated diseases include spinocerebellar ataxia type 2 (SCA2), amyotropic sclerosis (ALS), and parkinsonism.
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公开(公告)号：EP3974534A1
公开(公告)日：2022-03-30
申请号：EP21196639.5
申请日：2015-05-01
发明人： PRAKASH, Thazha, P. , SETH, Punit, P. , SWAYZE, Eric, E. , BHANOT, Sanjay , FREIER, Susan, M. , BUI, Huynh-Hoa
IPC分类号： C12N15/113 , A61K31/712 , A61K31/7125 , C07H21/02 , A61P5/06 , A61P19/00 , A61P43/00
摘要： The present embodiments provide methods, compounds, and compositions for treating, preventing, or ameliorating a disease associated with excess growth hormone using antisense compounds or oligonucleotides targeted to growth hormone receptor (GHR).
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公开(公告)号：EP3938514A1
公开(公告)日：2022-01-19
申请号：EP20773689.3
申请日：2020-03-13
发明人： BUI, Huynh-Hoa , FREIER, Susan, M.
IPC分类号： C12N15/113 , A61P25/08 , A61P25/24
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公开(公告)号：EP3822352A2
公开(公告)日：2021-05-19
申请号：EP20180985.2
申请日：2013-05-23
IPC分类号： C12N15/113 , A61P3/00 , A61P9/00 , A61P9/10 , A61P29/00
摘要： Disclosed herein are antisense compounds and methods for decreasing apo(a) to treat, prevent, or ameliorate diseases, disorders or conditions related to apo(a) or Lp(a). Certain diseases, disorders or conditions related to apo(a) or Lp(a) include inflammatory, cardiovascular and/or metabolic diseases, disorders or conditions. The antisense compounds disclosed herein can be used to treat such diseases, disorders or conditions in an individual in need thereof.
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