专利检索 cpc:"C12N2310/334120130101" 第 1 页

1.

发明公开
GAPMER ANTISENSE OLIGONUCLEOTIDES WITH MODIFIED BACKBONE CHEMISTRIES 审中-公开

公开(公告)号：EP4441224A1

公开(公告)日：2024-10-09

申请号：EP22902232.2

申请日：2022-12-02

申请人： Quralis Corporation

发明人： HINCKLEY, Sandra , BROWN, Duncan , ELBAUM, Daniel

IPC分类号： C12N15/113 , A61K31/7115 , A61K31/712 , A61K31/7125

CPC分类号： C12N15/113 , C12Y115/01001 , C12Y301/03016 , C12N2310/1120130101 , C12N2310/31820130101 , C12N2310/34120130101 , C12N15/1137 , C12N2310/2020170501 , C12N2310/334120130101 , C12N2310/32120130101 , A61K45/06

2.

发明公开
COMPOUNDS AND METHODS FOR REDUCING PSD3 EXPRESSION 审中-实审

公开(公告)号：EP4426837A2

公开(公告)日：2024-09-11

申请号：EP22886294.2

申请日：2022-10-31

申请人： Ionis Pharmaceuticals, Inc.

发明人： BUI, Huynh-Hoa , FREIER, Susan M. , LEE, Richard

IPC分类号： C12N15/113 , A61K31/712 , A61K31/7125

CPC分类号： C12N15/113 , C12N2310/31520130101 , C12N2310/334120130101 , C12N2310/323120130101 , C12N2310/32220130101 , C12N2310/34120130101

3.

发明公开
COMPOSITIONS AND METHODS FOR ENHANCING GENE SILENCING ACTIVITY OF OLIGONUCLEOTIDE COMPOUNDS 审中-实审

公开(公告)号：EP4413135A1

公开(公告)日：2024-08-14

申请号：EP22802312.3

申请日：2022-10-04

申请人： Amgen Inc.

发明人： LU, Jiamiao , OLLMANN, Michael , COLLINS, Patrick , LI, Chi-Ming , WANG, Songli

IPC分类号： C12N15/113

CPC分类号： C12N15/1137 , C12N15/113 , C12N2310/1420130101 , C12N2310/2020170501 , C12N2310/351520130101 , C12N2310/32120130101 , C12N2310/32220130101 , C12N2310/31520130101 , C12N2310/31720130101 , C12N2310/34520130101 , C12N2310/34620130101 , C12Y306/05002 , C12N2310/1120130101 , C12N2310/323120130101 , C12N2310/334120130101 , C12Y203/01051

4.

发明公开
PRE-MRNA SPLICE SWITCHING OR MODULATING OLIGONUCLEOTIDES COMPRISING BICYCLIC SCAFFOLD MOIETIES, WITH IMPROVED CHARACTERISTICS FOR THE TREATMENT OF GENETIC DISORDERS 审中-实审

公开(公告)号：EP4252845A3

公开(公告)日：2024-05-22

申请号：EP23175111.6

申请日：2017-07-05

申请人： BioMarin Technologies B.V.

发明人： VAN DEUTEKOM, Judith Christina Theodora , DE VISSER, Peter Christian

IPC分类号： C12N15/113 , A61K31/712 , A61K31/7125 , A61P21/00

CPC分类号： C12N15/113 , C12N2310/1120130101 , C12N2310/31520130101 , C12N2310/32120130101 , C12N2310/323120130101 , C12N2310/334120130101 , C12N2310/34620130101 , C12N2320/3320130101 , A61K31/34 , A61K31/712 , A61P21/00 , A61P21/04 , A61P43/00

摘要： The current invention provides antisense splice-switching oligonucleotides with improved characteristics that enhance clinical applicability for treating, ameliorating, preventing, and/or delaying neuromuscular disorders, such as DMD.

5.

发明公开
COMPOSITIONS AND METHODS FOR MODULATING APOLIPOPROTEIN C-III EXPRESSION 审中-公开

公开(公告)号：EP4438129A2

公开(公告)日：2024-10-02

申请号：EP24189241.3

申请日：2014-05-01

申请人： Ionis Pharmaceuticals, Inc.

发明人： PRAKASH, Thazha, P. , SETH, Punit, P. , SWAYZE, Eric, E. , GRAHAM, Mark, J.

IPC分类号： A61P43/00

CPC分类号： C12N2320/3220130101 , C12N2310/35120130101 , C12N2310/31520130101 , C12N2310/334120130101 , C12N2310/34120130101 , C12N2310/34620130101 , C12N2310/323120130101 , C12Y301/03048 , A61P25/00 , A61P43/00 , A61K47/549 , A61K47/59 , C12N2310/1120130101 , C12N15/1137 , C12N15/113 , C12N2310/351520130101

摘要： Provided herein are oligomeric compounds with conjugate groups targeting apoplipoprotein C-III (ApoCIII). In certain embodiments, the ApoCIII targeting oligomeric compounds are conjugated to N-Acetylgalactosamine. Also disclosed herein are conjugated oligomeric compounds targeting ApoCIII for use in decreasing ApoCIII to treat, prevent, or ameliorate diseases, disorders or conditions related to ApoCIII. Certain diseases, disorders or conditions related to ApoCIII include inflammatory, cardiovascular and/or metabolic diseases, disorders or conditions. The conjugated oligomeric compounds disclosed herein can be used to treat such diseases, disorders or conditions in an individual in need thereof.

6.

发明公开
CONJUGATED OLIGONUCLEOTIDES AND USES THEREOF 审中-实审转让

公开(公告)号：EP4408433A1

公开(公告)日：2024-08-07

申请号：EP22877591.2

申请日：2022-09-29

申请人： Ionis Pharmaceuticals, Inc. , Bicycle TX Limited

发明人： SETH, Punit, P. , OESTERGAARD, Michael , CARRER, Michele , TANOWITZ, Michael , RIGBY, Michael , SKYNNER, Michael , STANWAY, Steven , URBONAS, Liudvikas , VAN RIETSCHOTEN, Katerine

IPC分类号： A61K31/70 , A61K31/7088 , A61K31/713 , A61K47/50 , A61K47/51 , A61K47/68 , A61K31/00 , A61K47/00

CPC分类号： C12N15/113 , A61K47/64 , A61K47/60 , C12Y207/11 , C12N15/1137 , C12N15/111 , C12N2310/1120130101 , C12N2310/351320130101 , C12N2320/3220130101 , C12N2310/334120130101 , C12N2310/31520130101 , C12N2310/323120130101 , C12N2310/1420130101 , C12Y204/02008 , C12N2310/351520130101 , A61K31/7088

7.

发明公开
OLIGONUCLEOTIDE-BASED DELIVERY VEHICLE FOR OLIGONUCLEOTIDES AGENTS AND METHODS OF USE THEREOF 审中-实审

公开(公告)号：EP4367244A1

公开(公告)日：2024-05-15

申请号：EP22836938.5

申请日：2022-07-06

申请人： Ractigen Therapeutics

发明人： KANG, Moorim , LI, Longcheng , PLACE, Robert F.

IPC分类号： C12N15/113 , A61K38/14

CPC分类号： C12N2310/1420130101 , C12N2310/31520130101 , C12N2310/33520130101 , C12N2310/334120130101 , C12N2310/312520130101 , C12N2310/32120130101 , C12N2310/32220130101 , C12N2310/351920130101 , C12N2310/1120130101 , C12N15/1137 , C12Y115/01001 , C12N2310/351720130101 , A61K31/712 , A61K31/7115

8.

发明公开
MUSCLE TARGETING COMPLEXES AND USES THEREOF FOR TREATING MYOTONIC DYSTROPHY 审中-实审

公开(公告)号：EP4367143A1

公开(公告)日：2024-05-15

申请号：EP22838591.0

申请日：2022-07-08

申请人： Dyne Therapeutics, Inc.

发明人： ZANOTTI, Stefano , PICARIELLO, Tyler , WEEDEN, Timothy , DESJARDINS, Cody, A. , SUBRAMANIAN, Romesh, R. , QATANANI, Mohammed, T. , QUINN, Brendan , NAJIM, John

IPC分类号： C07K16/28 , A61K39/395 , A61K48/00 , A61P21/00 , C07K14/79 , C12N15/113

CPC分类号： A61P21/00 , C12Y207/11001 , C12N2310/1120130101 , C12N15/1137 , C12N2310/31520130101 , C12N2310/351320130101 , C12N2310/34120130101 , C12N2310/34620130101 , C12N2310/33520130101 , C12N2310/334120130101 , C12N2310/32220130101 , C12N2310/323120130101 , A01K2207/1520130101 , A01K2227/10520130101 , A01K2217/0020130101 , A61K47/6807 , A61K47/6849 , A61K47/6889 , C07K16/2881 , C07K2317/5520130101 , A61K2039/50520130101 , C07K2317/7720130101

9.

发明公开
LEUCINE-RICH REPEAT KINASE 2 (LRRK2) IRNA AGENT COMPOSITIONS AND METHODS OF USE THEREOF 审中-实审

公开(公告)号：EP4363588A1

公开(公告)日：2024-05-08

申请号：EP22834164.0

申请日：2022-06-29

申请人： Alnylam Pharmaceuticals Inc.

发明人： DANG, Lan Thi Hoang , MCININCH, James D. , SCHLEGEL, Mark K. , CASTORENO, Adam , NGUYEN, Tuyen M. , BARRY, Joseph , STRICOS, Matthew , LEBLANC, Sarah

IPC分类号： C12N15/113 , A61P25/16 , A61K31/7125

CPC分类号： A61P25/16 , C12N2310/1420130101 , C12N15/1137 , C12Y207/11001 , C12N2310/35120130101 , C12N2310/31520130101 , C12N2310/334120130101 , C12N2310/31820130101 , A61K31/713

10.

发明公开
OPA1 ANTISENSE OLIGOMERS FOR TREATMENT OF CONDITIONS AND DISEASES 审中-实审

公开(公告)号：EP4429714A2

公开(公告)日：2024-09-18

申请号：EP22893527.6

申请日：2022-11-08

申请人： Stoke Therapeutics, Inc.

发明人： AZNAREZ, Isabel , LIM, Kian Huat , KACH, Jacob

IPC分类号： A61K48/00 , A61K31/7088 , A61K39/395 , A61P27/02

CPC分类号： A61K31/712 , C12Y306/05005 , C12N15/1137 , C12N2310/1120130101 , C12N2310/31520130101 , C12N2320/1020130101 , C12N2320/3320130101 , C12N2310/323120130101 , C12N2310/334120130101 , C12N2310/34320130101 , C12N9/16