专利检索 ap:("Isis Pharmaceuticals, Inc." OR "Board of Regents of the University of Texas System") AND inv:"COREY, David" 第 1 页

1.

发明公开
METHODS AND COMPOUNDS USEFUL IN CONDITIONS RELATED TO REPEAT EXPANSION 有权
标题翻译：方法和化合物与重复扩增相关疾病

公开(公告)号：EP2751269A1

公开(公告)日：2014-07-09

申请号：EP12827475.0

申请日：2012-08-29

申请人： Isis Pharmaceuticals, Inc. , Board of Regents of the University of Texas System

发明人： PRAKASH, Thazha, P. , SWAYZE, Eric, E. , COREY, David , YU, Dongbo

IPC分类号： C12N15/11 , C07H21/04 , C12N5/00

CPC分类号： C12N15/113 , A61K31/7088 , C12N2310/113 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/323 , C12N2310/3341 , C12N2310/341 , C12N2310/343 , C12N2310/344 , C12N2310/351 , C12N2310/3521 , C12N2310/3533 , C12N2310/533 , C12N2320/34

摘要： Described are compounds and methods useful for the treatment and investigation of diseases and disorders associated with expanded repeat-containing RNA molecules.

2.

发明公开
METHODS AND COMPOUNDS USEFUL IN CONDITIONS RELATED TO REPEAT EXPANSION 审中-公开
标题翻译：在与重复扩增有关的条件中使用的方法和化合物

公开(公告)号：EP3027617A2

公开(公告)日：2016-06-08

申请号：EP14832900.6

申请日：2014-07-31

申请人： Ionis Pharmaceuticals, Inc. , Board of Regents of the University of Texas System

发明人： PRAKASH, Thazha, P. , HU, Jiaxin , LIU, Jing , YU, Dongbo , COREY, David , SWAYZE, Eric, E.

IPC分类号： C07D471/04

CPC分类号： C07H21/02 , C12N15/113 , C12N2310/11 , C12N2310/32 , C12N2320/34

摘要： Described are compounds and methods useful for the treatment and investigation of diseases and disorders associated with expanded repeat-containing RNA molecules. In certain embodiments, compounds and methods useful for the modulation of ATXN-3 pre-mRNA are described. In certain embodiments, compounds and methods useful for the modulation of ATN-1 mRNA are described.

摘要翻译： 描述了用于治疗和研究与包含扩增重复的RNA分子相关的疾病和病症的化合物和方法。在某些实施方案中，描述了用于调节ATXN-3前体mRNA的化合物和方法。在某些实施方案中，描述了用于调节ATN-1mRNA的化合物和方法。

3.

发明授权
METHODS AND COMPOUNDS USEFUL IN CONDITIONS RELATED TO REPEAT EXPANSION 有权
标题翻译：方法和化合物与重复扩增相关疾病

公开(公告)号：EP2751269B1

公开(公告)日：2016-03-23

申请号：EP12827475.0

申请日：2012-08-29

申请人： Ionis Pharmaceuticals, Inc. , Board of Regents of the University of Texas System

发明人： PRAKASH, Thazha, P. , SWAYZE, Eric, E. , COREY, David , YU, Dongbo

IPC分类号： C12N15/11 , C07H21/04 , C12N5/00

CPC分类号： C12N15/113 , A61K31/7088 , C12N2310/113 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/323 , C12N2310/3341 , C12N2310/341 , C12N2310/343 , C12N2310/344 , C12N2310/351 , C12N2310/3521 , C12N2310/3533 , C12N2310/533 , C12N2320/34

摘要： Described are compounds and methods useful for the treatment and investigation of diseases and disorders associated with expanded repeat-containing RNA molecules.

4.

发明公开
METHODS AND COMPOSITIONS USEFUL IN TREATMENT OF DISEASES OR CONDITIONS RELATED TO REPEAT EXPANSION 审中-公开
标题翻译：用于疾病的治疗或方法和组合物遭受具有重复加宽CONNECTION

公开(公告)号：EP2536738A1

公开(公告)日：2012-12-26

申请号：EP11740540.7

申请日：2011-02-08

申请人： Isis Pharmaceuticals, Inc. , Board Of Regents

发明人： COREY, David , BENNETT, C., Frank , SWAYZE, Eric, E. , GAGNON, Keith

IPC分类号： C07H21/04 , C12N15/11

CPC分类号： C12N15/113 , C12N2310/11 , C12N2310/315 , C12N2310/322 , C12N2310/3231 , C12N2310/341 , C12N2310/344 , C12N2310/346

摘要： The present invention is drawn to chemically-modified oligomers that are complementary to, and capable of hybridizing within the repeat region of CAG, CUG, or CCUG nucleotide repeat-containing RNAs (NRRs).