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公开(公告)号：EP2294420A2
公开(公告)日：2011-03-16
申请号：EP09759517.7
申请日：2009-06-05
申请人： The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services , British Columbia Cancer Agency Branch , UNIVERSITY OF ROCHESTER , Oregon Health&Science University , Arizona Board of Regents on behalf of The University of Arizona , Queen Mary And Westfield College, University Of London , Board of Regents of the University of Nebraska , University of Rochester , Universitat de Barcelona Hospital Clinic , Oslo University Hospital HF , Julius-Maximilians-University of Wuerzburg
发明人： STAUDT, Louis, M. , RIMSZA, Lisa , LISTER, Andrew T. , WEISENBURGER, Dennis , DELABIE, Jan , SMELAND, Erlend B. , HOLTE, Harald , KVALOY, Stein , BRAZIEL, Rita M. , FISHER, Richard I. , JARES, Pedro , LOPEZ-GUILLERMO, Armando , GUERRI, Elias Campo , JAFFE, Elaine S. , LENZ, George , WYNDHAM, Wilson H. , WRIGHT, George , DAVE, Sandeep S. , GASCOYNE, Randy D. , CONNORS, Joseph M. , MÜLLER-HERMELINK, Hans-Konrad , ROSENWALD, Andreas , OTT, German
IPC分类号： G01N33/574
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , G01N33/57407 , G01N2800/52 , G01N2800/56
摘要： The invention provides methods and materials related to a gene expression-based survival predictor for diffuse large B cell lymphoma (DLBCL) patients.
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公开(公告)号：EP3366313A1
公开(公告)日：2018-08-29
申请号：EP18167725.3
申请日：2012-04-06
申请人： Board Of Regents Of the University Of Texas System , Alzeca Biosciences, Llc , Board of Regents of the University of Houston System , Texas Children's Hospital
发明人： Annapragada, Ananth , Eriksen, Jason, L. , Tanifum, Eric, A. , Dasgupta, Indrani , Cook, Stephen, C.
CPC分类号： A61K49/1812 , A61K47/6911 , A61K49/0466
摘要： Lipid-based nanoparticle compositions are provided. The compositions generally comprise lipid-hydrophilic polymer-amyloid binding ligand conjugates, and may be liposomal compositions. The compositions, including the liposomal compositions, may be useful for imaging and/or the treatment of amyloid-β plaque deposits characteristic of Alzheimer's Disease.
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公开(公告)号：EP2294420B8
公开(公告)日：2015-10-21
申请号：EP09759517.7
申请日：2009-06-05
申请人： The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services , British Columbia Cancer Agency Branch , UNIVERSITY OF ROCHESTER , Oregon Health & Science University , Arizona Board of Regents on behalf of The University of Arizona , Queen Mary And Westfield College, University Of London , Board of Regents of the University of Nebraska , Universitat de Barcelona Hospital Clinic , Oslo University Hospital HF , Julius-Maximilians-University of Wuerzburg , Hospital Clinic
发明人： STAUDT, Louis, M. , RIMSZA, Lisa , LISTER, Andrew T. , WEISENBURGER, Dennis , DELABIE, Jan , SMELAND, Erlend B. , HOLTE, Harald , KVALOY, Stein , BRAZIEL, Rita M. , FISHER, Richard I. , JARES, Pedro , LOPEZ-GUILLERMO, Armando , GUERRI, Elias Campo , JAFFE, Elaine S. , LENZ, Georg , WYNDHAM, H.Wilson. , WRIGHT, George , DAVE, Sandeep S. , GASCOYNE, Randy D. , CONNORS, Joseph M. , MÜLLER-HERMELINK, Hans-Konrad , ROSENWALD, Andreas , OTT, German , WING, C Chan
IPC分类号： G01N33/574
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , G01N33/57407 , G01N2800/52 , G01N2800/56
摘要： The invention provides methods and materials related to a gene expression-based survival predictor for diffuse large B cell lymphoma (DLBCL) patients.
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公开(公告)号：EP3594359A1
公开(公告)日：2020-01-15
申请号：EP19170689.4
申请日：2014-11-05
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Services , British Columbia Cancer Agency Branch , Arizona Board of Regents on Behalf of University of Arizona , Universitat de Barcelona , Hospital Clínic de Barcelona , Cleveland Clinic , Board of Regents of the University of Nebraska , Oregon Health & Science University , Julius-Maximilians-University of Wuerzburg , Oslo University Hospital HF
发明人： STAUDT, Louis M. , WRIGHT, George W. , SCOTT, David William , CONNORS, Joseph M. , GASCOYNE, Randy D. , RIMSZA, Lisa , CAMPO GUERRI, Elias , GREINER, Timothy C. , COOK, James Robert , FU, Kai , WILLIAMS, Paul Michael , LIH, Chih-Jian , JAFFE, Elaine S. , BRAZIEL, Rita M. , ROSENWALD, Andreas , SMELAND, Erlend B. , CHAN, Wing C. , OTT, German , DELABIE, Jan , WEISENBURGER, Dennis , TUBBS, Raymond
IPC分类号： C12Q1/68
摘要： The invention is directed to methods for selecting a treatment option for an activated B cell-like diffuse large B cell lymphoma (ABC DLBCL) subject, a germinal center B cell-like diffuse large B cell lymphoma (GCB DLBCL) subject, a primary mediastinal B cell lymphoma (PMBL) subject, a Burkitt lymphoma (BL) subject, or a mantle cell lymphoma (MCL) subject by analyzing digital gene expression data obtained from the subject, e.g., from a biopsy sample.
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公开(公告)号：EP3066215B1
公开(公告)日：2019-04-24
申请号：EP14803288.1
申请日：2014-11-05
申请人： The United States of America, represented by the Secretary, Department of Health and Human Services , British Columbia Cancer Agency Branch , Arizona Board of Regents on Behalf of University of Arizona , Universitat de Barcelona , Hospital Clínic de Barcelona , Cleveland Clinic , Board of Regents of the University of Nebraska , Oregon Health & Science University , Julius-Maximilians-University of Wuerzburg , Oslo University Hospital HF
发明人： STAUDT, Louis M. , WRIGHT, George W. , SCOTT, David William , CONNORS, Joseph M. , GASCOYNE, Randy D. , RIMSZA, Lisa , CAMPO GUERRI, Elias , GREINER, Timothy C. , COOK, James Robert , FU, Kai , WILLIAMS, Paul Michael , LIH, Chih-Jian , JAFFE, Elaine S. , BRAZIEL, Rita M. , ROSENWALD, Andreas , SMELAND, Erlend B. , CHAN, Wing C. , OTT, German , DELABIE, Jan , WEISENBURGER, Dennis , TUBBS, Raymond
IPC分类号： C12Q1/68
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公开(公告)号：EP2694116B1
公开(公告)日：2018-06-13
申请号：EP12767275.6
申请日：2012-04-06
申请人： Board of Regents of the University of Texas System , Alzeca Biosciences, Llc , Board of Regents of the University of Houston System , Texas Children's Hospital
发明人： ANNAPRAGADA, Ananth , ERIKSEN, Jason, L. , TANIFUM, Eric, A. , DASGUPTA, Indrani , COOK, Stephen, C.
CPC分类号： A61K49/1812 , A61K47/6911 , A61K49/0466
摘要： Lipid-based nanoparticle compositions are provided. The compositions generally comprise lipid-hydrophilic polymer-amyloid binding ligand conjugates, and may be liposomal compositions. The compositions, including the liposomal compositions, may be useful for imaging and/or the treatment of amyloid-β plaque deposits characteristic of Alzheimer's Disease.
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7.发明公开METHOD FOR SUBTYPING LYMPHOMA TYPES BY MEANS OF EXPRESSION PROFILING 审中-公开VERFAHREN ZUR SUBTYPISIERUNG VON LYMPHOMTYPEN MITTELS EXPRESSIONSPROFILIERUNG
公开(公告)号：EP3066215A1
公开(公告)日：2016-09-14
申请号：EP14803288.1
申请日：2014-11-05
申请人： The United States of America, represented by the Secretary, Department of Health and Human Services , British Columbia Cancer Agency Branch , Arizona Board of Regents on Behalf of University of Arizona , Universitat de Barcelona , Hospital Clínic de Barcelona , Cleveland Clinic , Board of Regents of the University of Nebraska , Oregon Health & Science University , Julius-Maximilians-University of Wuerzburg , Oslo University Hospital HF
发明人： STAUDT, Louis M. , WRIGHT, George W. , SCOTT, David William , CONNORS, Joseph M. , GASCOYNE, Randy D. , RIMSZA, Lisa , CAMPO GUERRI, Elias , GREINER, Timothy C. , COOK, James Robert , FU, Kai , WILLIAMS, Paul Michael , LIH, Chih-Jian , JAFFE, Elaine S. , BRAZIEL, Rita M. , ROSENWALD, Andreas , SMELAND, Erlend B. , CHAN, Wing C. , OTT, German , DELABIE, Jan , WEISENBURGER, Dennis , TUBBS, Raymond
IPC分类号： C12Q1/68
CPC分类号： G06F19/20 , C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/158 , C12Q2600/166 , G06F19/12
摘要： The invention is directed to methods for selecting a treatment option for an activated B cell-like diffuse large B cell lymphoma (ABC DLBCL) subject, a germinal center B cell-like diffuse large B cell lymphoma (GCB DLBCL) subject, a primary mediastinal B cell lymphoma (PMBL) subject, a Burkitt lymphoma (BL) subject, or a mantle cell lymphoma (MCL) subject by analyzing digital gene expression data obtained from the subject, e.g., from a biopsy sample.
摘要翻译： 本发明涉及用于选择活化的B细胞样弥漫性大B细胞淋巴瘤（ABC DLBCL）受试者，生发中心B细胞样弥漫性大B细胞淋巴瘤（GCB DLBCL）受试者，原发性纵隔 B细胞淋巴瘤（PMBL）受试者，伯基特淋巴瘤（BL）受试者或套细胞淋巴瘤（MCL）受试者，通过分析从受试者获得的数字基因表达数据，例如来自活组织检查样品。
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公开(公告)号：EP2294420B1
公开(公告)日：2015-08-12
申请号：EP09759517.7
申请日：2009-06-05
申请人： The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services , British Columbia Cancer Agency Branch , UNIVERSITY OF ROCHESTER , Oregon Health & Science University , Arizona Board of Regents on behalf of The University of Arizona , Queen Mary And Westfield College, University Of London , Board of Regents of the University of Nebraska , University of Rochester , Universitat de Barcelona Hospital Clinic , Oslo University Hospital HF , Julius-Maximilians-University of Wuerzburg , Hospital Clinic
发明人： STAUDT, Louis, M. , RIMSZA, Lisa , LISTER, Andrew T. , WEISENBURGER, Dennis , DELABIE, Jan , SMELAND, Erlend B. , HOLTE, Harald , KVALOY, Stein , BRAZIEL, Rita M. , FISHER, Richard I. , JARES, Pedro , LOPEZ-GUILLERMO, Armando , GUERRI, Elias Campo , JAFFE, Elaine S. , LENZ, Georg , WYNDHAM, H.Wilson. , WRIGHT, George , DAVE, Sandeep S. , GASCOYNE, Randy D. , CONNORS, Joseph M. , MÜLLER-HERMELINK, Hans-Konrad , ROSENWALD, Andreas , OTT, German , WING, C Chan
IPC分类号： G01N33/574
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , G01N33/57407 , G01N2800/52 , G01N2800/56
摘要： The invention provides methods and materials related to a gene expression-based survival predictor for diffuse large B cell lymphoma (DLBCL) patients.
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公开(公告)号：EP2061872A2
公开(公告)日：2009-05-27
申请号：EP07814594.3
申请日：2007-08-30
申请人： The Board Of Regents For Oklahoma State University , The Board Of Regents Of The University Of Oklahoma
摘要： A novel clostridia bacterial species (Clostridium ragsdalei, ATCC BAA-622 and/or PTA-7826, 'P11') is provided. P11 is capable of synthesizing, from waste gases, products which are useful as biofuel. In particular, P11 can convert CO to ethanol. Thus, this novel bacterium transforms waste gases (e.g. syngas and refinery wastes) into useful products. P11 also catalyzes the production of acetate.
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10.发明授权Small molecule inhibitors of the pleckstrin homology domain and method for using same 有权pleckstrin同源结构域的小分子抑制剂及其使用方法
公开(公告)号：EP2428504B1
公开(公告)日：2017-05-17
申请号：EP11181871.2
申请日：2009-04-14
申请人： The Board of Regents of the University of Texas System , The Arizona Board of Regents on behalf of the University of Arizona
发明人： Mahadevan, Daruka , Meuillet, Emmanuelle, J , Mash, Eugene, A , Gokhale, Vijay, M , Powis, Garth , Zhang, Shuxing
IPC分类号： C07D213/75 , C07D237/18 , C07D239/42 , C07D239/69 , C07D263/40 , C07D271/10 , C07D285/12 , C07D333/36 , C07D403/12 , C07D405/12 , C07D413/12 , C07D417/12 , C07D285/135 , C07D295/135 , C07D285/125 , C07D401/12 , C07D417/10 , C07D417/06 , C07D413/06 , A61K31/433 , A61P35/00
CPC分类号： A61K31/433 , C07C59/90 , C07C65/40 , C07C233/75 , C07C235/64 , C07C237/42 , C07C271/22 , C07C311/21 , C07C317/14 , C07C317/18 , C07C317/28 , C07C317/44 , C07C323/65 , C07D213/50 , C07D213/643 , C07D213/74 , C07D213/76 , C07D231/06 , C07D231/12 , C07D231/20 , C07D231/38 , C07D231/42 , C07D233/20 , C07D233/26 , C07D233/64 , C07D237/08 , C07D237/18 , C07D239/26 , C07D239/34 , C07D239/38 , C07D239/42 , C07D239/52 , C07D261/08 , C07D261/20 , C07D263/32 , C07D263/42 , C07D263/56 , C07D271/10 , C07D271/113 , C07D277/52 , C07D277/64 , C07D285/12 , C07D285/125 , C07D285/135 , C07D295/135 , C07D295/192 , C07D295/26 , C07D333/38 , C07D401/12 , C07D403/12 , C07D405/12 , C07D413/06 , C07D417/06 , C07D417/10 , C07D417/12 , C07F9/65583
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