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1.发明授权SUBSTITUTED PHENOXY N-ALKYLATED THIAZOLEDINEDIONE AS ESTROGEN RELATED RECEPTOR-ALPHA MODULATORS 有权取代的苯氧基-N-烷基化THIAZOLEDINDIONE作为雌激素相关受体α调节剂
公开(公告)号：EP2132188B1
公开(公告)日：2011-12-14
申请号：EP08731517.2
申请日：2008-03-06
IPC分类号： C07D277/34
CPC分类号： C07D277/34 , C07D417/06
摘要： The present invention relates to compounds of Formula (I), methods for preparing these compounds, compositions, intermediates and derivatives thereof and for treating a condition including but not limited to ankylosing spondylitis, artherosclerosis, arthritis (such as rheumatoid arthritis, infectious arthritis, childhood arthritis, psoriatic arthritis, reactive arthritis), bone-related diseases (including those related to bone formation), breast cancer (including those unresponsive to anti-estrogen therapy), cardiovascular disorders, cartilage-related disease (such as cartilage injury/loss, cartilage degeneration, and those related to cartilage formation), chondrodysplasia, chondrosarcoma, chronic back injury, chronic bronchitis, chronic inflammatory airway disease, chronic obstructive pulmonary disease, diabetes, disorders of energy homeostasis, gout, pseudogout, lipid disorders, metabolic syndrome, multiple myeloma, obesity, osteoarthritis, osteogenesis imperfecta, osteolytic bone metastasis, osteomalacia, osteoporosis, Paget's disease, periodontal disease, polymyalgia rheumatica, Reiter's syndrome, repetitive stress injury, hyperglycemia, elevated blood glucose level, and insulin resistance.
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2.发明公开SUBSTITUTED PHENOXY THIAZOLIDINEDIONES AS ESTROGEN RELATED RECEPTOR-ALPHA MODULATORS 审中-公开取代PHENOXYTHIAZOLIDINDIONE作为雌激素相关受体α调节剂
公开(公告)号：EP2129668A1
公开(公告)日：2009-12-09
申请号：EP08731504.0
申请日：2008-03-06
发明人： GAUL, Michael , KIM, Alexander , SEARLE, Lily, Lee , PATCH, Raymond , RENTZEPERIS, Dionisios , XU, Guozhang , ZHU, Xizhen
IPC分类号： C07D263/44 , C07D277/34 , A61P11/00 , A61P19/00 , A61P3/04 , A61P3/10 , A61P35/00 , A61K31/426 , A61K31/421
CPC分类号： C07D277/34 , C07D263/44
摘要： The present invention relates to compounds of Formula (I): methods for preparing these compounds, compositions, intermediates and derivatives thereof and for treating a condition including but not limited to ankylosing spondylitis, artherosclerosis, arthritis (such as rheumatoid arthritis, infectious arthritis, childhood arthritis, psoriatic arthritis, reactive arthritis), bone-related diseases (including those related to bone formation), breast cancer (including those unresponsive to anti-estrogen therapy), cardiovascular disorders, cartilage-related disease (such as cartilage injury/loss, cartilage degeneration, and those related to cartilage formation), chondrodysplasia, chondrosarcoma, chronic back injury, chronic bronchitis, chronic inflammatory airway disease, chronic obstructive pulmonary disease, diabetes, disorders of energy homeostasis, gout, pseudogout, lipid disorders, metabolic syndrome, multiple myeloma, obesity, osteoarthritis, osteogenesis imperfecta, osteolytic bone metastasis, osteomalacia, osteoporosis, Paget's disease, periodontal disease, polymyalgia rheumatica, Reiter's syndrome, repetitive stress injury, hyperglycemia, elevated blood glucose level, and insulin resistance.
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3.发明公开ARYLIDENES FOR THE TREATMENT OF ESTROGEN RELATED RECEPTOR-ALPHA MEDIATED DISEASES 审中-公开Arylidenes雌激素相关受体-α介导的疾病的治疗
公开(公告)号：EP1781271A1
公开(公告)日：2007-05-09
申请号：EP05769266.7
申请日：2005-07-08
IPC分类号： A61K31/085 , A61K31/415 , A61K31/4152 , A61K31/426 , A61P3/04 , A61P3/06 , A61P3/10 , A61P9/00 , A61P9/10 , A61P11/08 , A61P19/00 , A61P35/00
CPC分类号： A61K31/198 , A61K31/085 , A61K31/277 , A61K31/415 , A61K31/4152 , A61K31/42 , A61K31/426
摘要： Therapeutic methods of using certain heterocyclic arylidene aryl ether compounds for treating diseases or disorders mediated through modulation of estrogen related receptor alpha are described.
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4.发明公开SUBSTITUTED PHENOXY AMINOTHIAZOLONES AS ESTROGEN RELATED RECEPTOR-ALPHA MODULATORS 审中-公开取代PHENOXYAMINOTHIAZOLONE AS与雌激素有关受体-α的调节剂
公开(公告)号：EP2134698A1
公开(公告)日：2009-12-23
申请号：EP08731528.9
申请日：2008-03-06
IPC分类号： C07D277/34 , C07D417/04 , A61K31/427 , A61P19/00 , A61P35/00
CPC分类号： C07D277/34 , C07D417/04
摘要： The present invention relates to compounds of Formula (I), methods for preparing these compounds, compositions, intermediates and derivatives thereof and for treating a condition including but not limited to ankylosing spondylitis, artherosclerosis, arthritis (such as rheumatoid arthritis, infectious arthritis, childhood arthritis, psoriatic arthritis, reactive arthritis), bone-related diseases (including those related to bone formation), breast cancer (including those unresponsive to anti-estrogen therapy), cardiovascular disorders, cartilage-related disease (such as cartilage injury/loss, cartilage degeneration, and those related to cartilage formation), chondrodysplasia, chondrosarcoma, chronic back injury, chronic bronchitis, chronic inflammatory airway disease, chronic obstructive pulmonary disease, diabetes, disorders of energy homeostasis, gout, pseudogout, lipid disorders, metabolic syndrome, multiple myeloma, obesity, osteoarthritis, osteogenesis imperfecta, osteolytic bone metastasis, osteomalacia, osteoporosis, Paget's disease, periodontal disease, polymyalgia rheumatica, Reiter's syndrome, repetitive stress injury, hyperglycemia, elevated blood glucose level, and insulin resistance.
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5.发明公开SUBSTITUTED PHENOXY N-ALKYLATED THIAZOLEDINEDIONE AS ESTROGEN RELATED RECEPTOR-ALPHA MODULATORS 有权取代的苯氧基-N-烷基化THIAZOLEDINDIONE作为雌激素相关受体α调节剂
公开(公告)号：EP2132188A2
公开(公告)日：2009-12-16
申请号：EP08731517.2
申请日：2008-03-06
IPC分类号： C07D277/34
CPC分类号： C07D277/34 , C07D417/06
摘要： The present invention relates to compounds of Formula (I), methods for preparing these compounds, compositions, intermediates and derivatives thereof and for treating a condition including but not limited to ankylosing spondylitis, artherosclerosis, arthritis (such as rheumatoid arthritis, infectious arthritis, childhood arthritis, psoriatic arthritis, reactive arthritis), bone-related diseases (including those related to bone formation), breast cancer (including those unresponsive to anti-estrogen therapy), cardiovascular disorders, cartilage-related disease (such as cartilage injury/loss, cartilage degeneration, and those related to cartilage formation), chondrodysplasia, chondrosarcoma, chronic back injury, chronic bronchitis, chronic inflammatory airway disease, chronic obstructive pulmonary disease, diabetes, disorders of energy homeostasis, gout, pseudogout, lipid disorders, metabolic syndrome, multiple myeloma, obesity, osteoarthritis, osteogenesis imperfecta, osteolytic bone metastasis, osteomalacia, osteoporosis, Paget's disease, periodontal disease, polymyalgia rheumatica, Reiter's syndrome, repetitive stress injury, hyperglycemia, elevated blood glucose level, and insulin resistance.
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