公开(公告)号：EP4347588A1

公开(公告)日：2024-04-10

申请号：EP22729029.3

申请日：2022-05-30

申请人： JANSSEN Pharmaceutica NV

发明人： CAI, Wei ,  THURING, Johannes Wilhelmus J. ,  HULPIA, Fabian ,  DAI, Xuedong ,  LI, Ming ,  DENG, Xiangjun ,  LIANG, Chao ,  NG, Alicia Tee Fuay ,  SUN, Zhen ,  ZHANG, Zhigao ,  DEMIN, Samuël Dominique ,  DYUBANKOVA, Natalia Nikolaevna ,  JOUFFROY, Matthieu, Dominique ,  LEPRI, Susan ,  DARVILLE, Nicolas Freddy Jacques Bruno ,  PANDE, Vineet ,  SCHEPENS, Wim Bert Griet ,  EDWARDS, James Patrick ,  QUEROLLE, Olivier Alexis Georges

IPC分类号： C07D471/04 ,  C07D487/04 ,  A61P35/00

公开(公告)号：EP3974428A1

公开(公告)日：2022-03-30

申请号：EP21199207.8

申请日：2016-08-25

申请人： Janssen Pharmaceutica NV

发明人： WU, Tongfei ,  BREHMER, Dirk ,  BEKE, Lijs ,  BOECKX, An ,  DIELS, Gaston Stanislas Marcella ,  GILISSEN, Ronaldus Arnodus Hendrika Joseph ,  LAWSON, Edward Charles ,  PANDE, Vineet ,  PARADE, Marcus Cornelis Bernardus Catharina ,  SCHEPENS, Wim Bert Griet ,  THURING, Johannes Wilhelmus John F. ,  VIELLEVOYE, Marcel ,  SUN, Weimei ,  MEERPOEL, Lieven

IPC分类号： C07D471/04 ,  A61K31/519 ,  A61K31/53

摘要： The present invention relates novel 6-6 bicyclic aromatic ring substituted nucleoside analogues of Formula (I)

wherein the variables have the meaning defined in the claims. The compounds according to the present invention are useful as PRMT5 inhibitors. The invention further relates to pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.

公开(公告)号：EP3519413A1

公开(公告)日：2019-08-07

申请号：EP17781060.3

申请日：2017-10-02

申请人： Janssen Pharmaceutica NV

发明人： WU, Tongfei ,  BREHMER, Dirk ,  BEKE, Lijs ,  BOECKX, An ,  DIELS, Gaston Stanislas Marcella ,  LAWSON, Edward Charles ,  MEERPOEL, Lieven ,  PANDE, Vineet ,  PARADÉ, Marcus Cornelis Bernardus Catharina ,  SCHEPENS, Wim Bert Griet ,  SUN, Weimei ,  THURING, Johannes Wilhelmus John F. ,  VIELLEVOYE, Marcel

IPC分类号： C07D487/04 ,  C07D519/00 ,  A61K31/519 ,  A61P35/00 ,  A61P37/00