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公开(公告)号：EP2368899B8
公开(公告)日：2017-10-18
申请号：EP09829169.3
申请日：2009-11-27
申请人： JAPAN AS REPRESENTED BY THE DIRECTOR-GENERAL OF NATIONAL INSTITUTE OF INFECTIOUS DISEASES , NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY , Saitama Medical University , NOF CORPORATION
IPC分类号： C07K7/06 , A61K9/127 , A61K39/00 , A61K47/28 , A61P31/16 , A61P37/04 , A61K9/00 , C07K14/005 , A61K39/145 , A61K39/12
CPC分类号： A61K39/145 , A61K9/0019 , A61K9/127 , A61K9/1277 , A61K39/12 , A61K2039/55555 , A61K2039/55561 , C07K14/005 , C12N2740/16222 , C12N2740/16234
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公开(公告)号：EP2368899B1
公开(公告)日：2017-09-06
申请号：EP09829169.3
申请日：2009-11-27
申请人： JAPAN AS REPRESENTED BY THE DIRECTOR-GENERAL OF NATIONAL INSTITUTE OF INFECTIOUS DISEASES , National University Corporation Hokkaido University , Saitama Medical University , NOF CORPORATION
IPC分类号： C07K7/06 , A61K9/127 , A61K39/00 , A61K47/28 , A61P31/16 , A61P37/04 , A61K9/00 , C07K14/005 , A61K39/145 , A61K39/12
CPC分类号： A61K39/145 , A61K9/0019 , A61K9/127 , A61K9/1277 , A61K39/12 , A61K2039/55555 , A61K2039/55561 , C07K14/005 , C12N2740/16222 , C12N2740/16234
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公开(公告)号：EP2615104B1
公开(公告)日：2017-03-22
申请号：EP11823616.5
申请日：2011-09-07
申请人： Saitama Medical University , JAPAN AS REPRESENTED BY THE DIRECTOR-GENERAL OF NATIONAL INSTITUTE OF INFECTIOUS DISEASES , NOF CORPORATION
IPC分类号： C07K7/06 , A61K9/127 , A61K39/29 , A61K39/39 , A61P31/14 , C12N5/0783 , C12N15/117
CPC分类号： A61K47/6911 , A61K31/7088 , A61K39/12 , A61K39/29 , A61K47/544 , A61K2039/55555 , A61K2039/572 , A61K2039/6018 , C12N7/00 , C12N15/117 , C12N2310/17 , C12N2710/24143 , C12N2770/24234
摘要： The present invention provides a peptide-bound liposome wherein the peptide contains a partial amino acid sequence having a length of not less than 9 amino acids in the amino acid sequence of hepatitis C virus NS3 protein, has a length of 9 to 11 amino acids, and is capable of inducing cytotoxic T lymphocytes, the liposome contains a phospholipid containing an acyl group having 14 to 24 carbon atoms and one unsaturated bond or a hydrocarbon group having 14 to 24 carbon atoms and one unsaturated bond, and a liposome stabilizer, and the peptide is bound to the surface of the liposome; a cytotoxic T lymphocyte activator containing the peptide-bound liposome; and a hepatitis C virus vaccine.
摘要翻译： 本发明提供肽结合的脂质体，其中肽含有在丙型肝炎病毒NS3蛋白的氨基酸序列中长度不少于9个氨基酸的部分氨基酸序列，长度为9至11个氨基酸， 并且能够诱导细胞毒性T淋巴细胞，脂质体含有含有14〜24个碳原子的酰基和1个不饱和键或14〜24个碳原子的烃基和1个不饱和键的磷脂和脂质体稳定剂， 肽结合到脂质体的表面; 含有肽结合脂质体的细胞毒性T淋巴细胞激活剂; 和丙型肝炎病毒疫苗。
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公开(公告)号：EP2368899A1
公开(公告)日：2011-09-28
申请号：EP09829169.3
申请日：2009-11-27
申请人： Japan As Represented By Director-General Of National Institute Of Infectious Diseases , National University Corporation Hokkaido University , Saitama Medical University , NOF Corporation
CPC分类号： A61K39/145 , A61K9/0019 , A61K9/127 , A61K9/1277 , A61K39/12 , A61K2039/55555 , A61K2039/55561 , C07K14/005 , C12N2740/16222 , C12N2740/16234
摘要： The present invention provides an avian influenza vaccine containing a peptide-bound liposome wherein;
the peptide contains:
(1) an amino acid sequence shown by any one of SEQ ID NO:1 to 9, or
(2) an amino acid sequence shown by any one of SEQ ID NO:1 to 9 wherein one or two amino acids are substituted,
has a length of 9 to 11 amino acids, and
is capable of inducing HLA-restricted cytotoxic T lymphocytes; wherein the liposome contains a phospholipid having an acyl group with 14 to 24 carbon atoms and one unsaturated bond or a hydrocarbon group with 14 to 24 carbon atoms and one unsaturated bond, and a liposome stabilizer; and
wherein the peptide is bound to the surface of the liposome.-
公开(公告)号：EP2615104A1
公开(公告)日：2013-07-17
申请号：EP11823616.5
申请日：2011-09-07
申请人： Saitama Medical University , Japan as Represented by Director-General of National Institute of Infectious Diseases , NOF Corporation
IPC分类号： C07K7/06 , A61K9/127 , A61K39/29 , A61K39/39 , A61P31/14 , C12N5/0783 , C12N15/117
CPC分类号： A61K47/6911 , A61K31/7088 , A61K39/12 , A61K39/29 , A61K47/544 , A61K2039/55555 , A61K2039/572 , A61K2039/6018 , C12N7/00 , C12N15/117 , C12N2310/17 , C12N2710/24143 , C12N2770/24234
摘要： The present invention provides a peptide-bound liposome wherein the peptide contains a partial amino acid sequence having a length of not less than 9 amino acids in the amino acid sequence of hepatitis C virus NS3 protein, has a length of 9 to 11 amino acids, and is capable of inducing cytotoxic T lymphocytes, the liposome contains a phospholipid containing an acyl group having 14 to 24 carbon atoms and one unsaturated bond or a hydrocarbon group having 14 to 24 carbon atoms and one unsaturated bond, and a liposome stabilizer, and the peptide is bound to the surface of the liposome; a cytotoxic T lymphocyte activator containing the peptide-bound liposome; and a hepatitis C virus vaccine.
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