公开(公告)号：EP3034076A4

公开(公告)日：2016-10-19

申请号：EP14836229

申请日：2014-08-13

申请人： JC WUXI COMPANY INC

发明人： CHENG JINGCAI ,  ZHANG CHUNXIA ,  CHENG ZHIWEI

IPC分类号： A61K31/26 ,  A61K45/06 ,  A61P35/00

CPC分类号： A61K31/26 ,  A61K31/16 ,  A61K31/165 ,  A61K31/167 ,  A61K31/17 ,  A61K31/282 ,  A61K31/33 ,  A61K31/337 ,  A61K31/4164 ,  A61K31/4166 ,  A61K31/4184 ,  A61K31/436 ,  A61K31/437 ,  A61K31/44 ,  A61K31/4412 ,  A61K31/4439 ,  A61K31/4745 ,  A61K31/475 ,  A61K31/4985 ,  A61K31/506 ,  A61K31/517 ,  A61K31/519 ,  A61K31/58 ,  A61K31/69 ,  A61K31/704 ,  A61K31/7068 ,  A61K31/7076 ,  A61K33/24 ,  A61K33/36 ,  A61K38/10 ,  A61K38/14 ,  A61K2300/00

摘要： The present invention relates to a combined application of isothiocyanate compounds and anti-cancer drugs, in particular to a composition, comprising: (A) a therapeutically effective amount of a first active ingredient, the first active ingredient being an isothiocyanate compound or derivative thereof; (B) a therapeutically effective amount of a second active ingredient, the second active ingredient being anti-cancer drugs effecting or influencing DNA, kinase inhibitor anti-cancer drugs or endocrine therapy hormonal anti-cancer drugs, the mass ratio of the first active ingredient and the second active ingredient being from 1:10000 to 10000:1. Also disclosed are an active ingredient composition, kit, pharmaceutical composition and uses thereof in the preparation of anti-cancer drugs. The composition, active ingredient composition and kit have excellent effect of inhibiting the growth of cancer cells.