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公开(公告)号：EP0945727A1
公开(公告)日：1999-09-29
申请号：EP99302242.5
申请日：1999-03-23
IPC分类号： G01N33/50 , G01N33/569
CPC分类号： G01N33/5091 , G01N33/56988 , G01N2333/715
摘要： The present invention provides a novel diagnostic method for HIV infection, which comprises utilising as aspecific index of infection a T-cell growth factor receptor (IL-9R) capable of expressing specifically in T-cell lymphocytes. HIV infection can be diagnosed by quantitation of an expressed amount of IL-9R in the culture supernatant of CD8-positive cells, etc.
摘要翻译： 本发明提供一种HIV感染的新型诊断方法，其包括利用能够在T细胞淋巴细胞中特异性表达的T细胞生长因子受体（IL-9R）作为感染的特异性指标。 通过定量CD8阳性细胞等的培养上清液中IL-9R的表达量可以诊断HIV感染。
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公开(公告)号：EP0945727B1
公开(公告)日：2003-06-11
申请号：EP99302242.5
申请日：1999-03-23
IPC分类号： G01N33/50 , G01N33/569
CPC分类号： G01N33/5091 , G01N33/56988 , G01N2333/715
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3.发明公开Cells expressing a chimera receptor and their uses 审中-公开Zellen，die einchimärischenRezeptor exprimieren，und deren Verwendungen
公开(公告)号：EP0950710A2
公开(公告)日：1999-10-20
申请号：EP99106794.3
申请日：1999-04-06
CPC分类号： C07K14/72 , C07K14/715 , C07K2319/00 , C07K2319/02
摘要： The present invention provides a chimera gene as constructed by fusing the gene for the extracelluar region of human growth hormone receptor with the genes for the transmembrane and cytoplasmic regions of thrombopoietin receptor, an expression plasmid for the said gene and animal cells capable of expressing the protein encoded by the said gene.
The human-growth-hormone dependent animal cell line transformed with an expression plasmid for the said gene are useful in screening hormones which show affinity for the chimera receptor, as well as their agonists and antagonists.摘要翻译： 本发明提供了通过将人生长激素受体的细胞外区域的基因与血小板生成素受体的跨膜和细胞质区域的基因融合而构建的嵌合体基因，所述基因的表达质粒和能够表达蛋白质的动物细胞 由所述基因编码。 用所述基因的表达质粒转化的人生长激素依赖性动物细胞系可用于筛选对嵌合体受体以及它们的激动剂和拮抗剂显示亲和力的激素。
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公开(公告)号：EP0892046A3
公开(公告)日：1999-06-30
申请号：EP98111352.5
申请日：1998-06-19
CPC分类号： C07K14/72
摘要： The present invention provides materials capable of screening human melatonin which comprise an animal cell containing an expression plasmid for the gene encoding a human melatonin receptor protein and having said protein expressed therein, as well as a method for screening the same, thus permitting not only human melatonin but also hormones showing affinity for the same, and their agonists or antagonists to be screened with an enhanced degree of precision.
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公开(公告)号：EP0950710A3
公开(公告)日：1999-10-27
申请号：EP99106794.3
申请日：1999-04-06
CPC分类号： C07K14/72 , C07K14/715 , C07K2319/00 , C07K2319/02
摘要： The present invention provides a chimera gene as constructed by fusing the gene for the extracelluar region of human growth hormone receptor with the genes for the transmembrane and cytoplasmic regions of thrombopoietin receptor, an expression plasmid for the said gene and animal cells capable of expressing the protein encoded by the said gene.
The human-growth-hormone dependent animal cell line transformed with an expression plasmid for the said gene are useful in screening hormones which show affinity for the chimera receptor, as well as their agonists and antagonists.摘要翻译： 本发明提供了通过将人生长激素受体的细胞外区域的基因与血小板生成素受体的跨膜和胞质区域的基因融合而构建的嵌合体基因，所述基因的表达质粒和能够表达该蛋白质的动物细胞 由所述基因编码。 用所述基因的表达质粒转化的人生长激素依赖性动物细胞系可用于筛选对嵌合受体显示亲和性的激素以及它们的激动剂和拮抗剂。
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6.发明公开Melatonin-receptor expression cells and their uses 失效Melatoninrezeptorexpressionszellen und deren Anwendung
公开(公告)号：EP0892046A2
公开(公告)日：1999-01-20
申请号：EP98111352.5
申请日：1998-06-19
CPC分类号： C07K14/72
摘要： The present invention provides materials capable of screening human melatonin which comprise an animal cell containing an expression plasmid for the gene encoding a human melatonin receptor protein and having said protein expressed therein, as well as a method for screening the same, thus permitting not only human melatonin but also hormones showing affinity for the same, and their agonists or antagonists to be screened with an enhanced degree of precision.
摘要翻译： 本发明提供能够筛选人褪黑激素的材料，其包含含有编码人褪黑素受体蛋白的基因的表达质粒的动物细胞，并且其中表达有所述蛋白质，以及其筛选方法，因此不仅允许人 褪黑激素以及激素显示出与之相似的激素，并且其激动剂或拮抗剂以更高的精度进行筛选。
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