公开(公告)号：EP1457218A1

公开(公告)日：2004-09-15

申请号：EP02790796.3

申请日：2002-12-18

申请人： JMS Co., Ltd. ,  Kitakyushu Institute of Biophysics Co.,Ltd.

发明人： KIM, Sung-Teh ,  TAOKA, Masahiro c/o Kitakyushu Nefurokuriniku ,  YAMAMOTO, Chieko ,  YAMANAKA, Kunihiko ,  MASAOKA, Katunori c/o JMS CO., ChiyodaFactory

IPC分类号： A61M1/14

CPC分类号： A61M1/3626 ,  A61M1/16 ,  A61M1/1605 ,  A61M1/165 ,  A61M1/34 ,  A61M1/3403 ,  A61M1/3607 ,  A61M1/3643 ,  A61M1/3644 ,  A61M1/3646 ,  A61M1/3649 ,  A61M2205/15 ,  A61M2205/33 ,  A61M2205/3331 ,  A61M2205/3334 ,  A61M2205/3344 ,  A61M2205/3365 ,  A61M2205/3379 ,  A61M2205/3389

摘要： An apparatus for blood dialysis composed at least of a hemodialyzer (a) whereby blood is brought into contact with a dialysate via a semipermeable membrane and thus purified; a blood circulation system (b) composed of a blood circuit in the arterial side whereby blood is taken out from a patient and flown into the hemodialyzer and another blood circuit in the venous side whereby the blood flown out from the hemodialyzer is returned to the patient; a dialysate supplying/discharging system (c) for supplying and discharging the dialysate composed of a dialysate-supply line for supplying the dialysate to the hemodialyzer and a dialysate-discharge line for discharging the dialysate flown out from the hemodialyzer, and a means (d) of controlling the back-filtration speed. Owing to this constitution, individual steps from the preparation of the dialysis (treatment) to the completion of the treatment and the change from a specific step to the next step can be safely, surely and quickly carried out in most cases. Moreover, a series of therapeutic procedures (i.e., blood collection, initiation of blood dialysis, collection and completion) can be automated.

摘要翻译： 至少由血液透析器（a）构成的用于血液透析的装置，其中血液通过半透膜与透析液接触并由此净化; 血液循环系统（b），其由动脉侧的血液回路构成，从患者体内取出血液并流入血液透析器，在静脉侧流通血液回路，使从血液透析器流出的血液返回到患者体内 ; 用于向由血液透析器供给透析液的透析液供给管路的透析液供给排出用的透析液供给排出系统（c）和从血液透析器流出的透析液的排出管线， ）控制回滤速度。 由于这种结构，在大多数情况下，可以安全，可靠和快速地进行从准备透析（治疗）到完成治疗的各个步骤以及从特定步骤到下一步骤的改变。 此外，可以自动化一系列治疗程序（即采血，开始血液透析，收集和完成）。

公开(公告)号：EP1295617A1

公开(公告)日：2003-03-26

申请号：EP01941049.7

申请日：2001-06-14

申请人： JMS Co., Ltd. ,  Kitakyushu Institute of Biophysics Co.,Ltd.

发明人： KIM, Sung-Teh ,  TAOKA, Masahiro Kitakyushu Nefurokuriniku ,  YAMAMOTO, Tieko ,  YAMANAKA, Kunihiko ,  MASAOKA, Katunori

IPC分类号： A61M1/14

CPC分类号： A61M1/16 ,  A61M1/1645 ,  A61M1/3427 ,  A61M1/3465 ,  A61M1/3643 ,  A61M1/3644 ,  A61M1/3646 ,  A61M1/3649 ,  Y10S128/03

摘要： An automatic dialyzer for purifying blood brought into contact with a dialysate via a semi-impermeable membrane, comprising at least a blood circulating system and a dialysate supply/discharge system, characterized in that the blood line of the blood circulating system is connected to an overflow line having a reversibly-rotatable blood pump and also having a blood chamber and an open/close means for overflowing of liquid from the blood chamber to the outside of the blood line, and liquid supply means, for supplying liquid in both forward and reverse directions and being able to regulate the supply amount of the dialysate for water removing/liquid replenishing, are provided to a first bypass line and/or a second bypass line, the supply speed of the liquid supply means and the supply speed of the blood pump being regulatable in conjunction with each other; and a dialyzing method using the automatic dialyzer.

摘要翻译： 一种用于净化通过半不透膜与透析液接触的血液的自动透析器，其包括至少一个血液循环系统和透析液供给/排出系统，其特征在于，血液循环系统的血液线连接到溢流 具有可逆旋转的血液泵，并且还具有用于使液体从血液室向血液管线溢出的血液腔和打开/关闭装置的液体供给装置，用于向前后方向供给液体 并且能够调节用于除水/液体补充的透析液的供给量，设置在第一旁通管线和/或第二旁通管路上，液体供给装置的供给速度和血液泵的供给速度为 相互配合; 和使用自动透析器的透析法。

公开(公告)号：EP1867353A1

公开(公告)日：2007-12-19

申请号：EP06730779.3

申请日：2006-03-31

申请人： JMS Co. ,  Kitakyushu Institute of Biophysics Co.,Ltd.

发明人： KIM, Sung-Teh ,  YAMAMOTO, Chieko ,  SEGAWA, Kayoko, Espoir Asakawa 205 ,  YAMANAKA, Kunihiko, c/o JMS CO. ,  MASAOKA, Katsunori, c/o JMS CO.

IPC分类号： A61M1/14 ,  B01D61/30 ,  B01D65/02

CPC分类号： A61M1/16 ,  A61M1/1609 ,  A61M1/3612 ,  A61M1/365 ,  A61M2205/3331 ,  A61M2205/50 ,  A61M2205/7554 ,  B01D61/32 ,  B01D65/02 ,  B01D2321/04

摘要： Provided is a hemodialyzer in which deterioration in membrane performance of a hollow fiber with time can be grasped accurately during dialysis and the performance can be recovered quickly and positively. The hemodialyzer, constituted by connecting an artery side blood circuit (2) having a blood pump (7) to the artery side of a dialyzer (1), connecting a vein side blood circuit (3) to the vein side of the dialyzer (1), and connecting a dialysate supply line (4) and a dialysate discharge line (5), respectively, to the side face of the dialyzer (1), is provided with a detector (15) for determining the pressure in the blood circuit, and a detector (16) for determining the pressure in the dialysate line, in which transmembrane pressure is calculated based on the determined pressures, and reverse filtering is performed by the dialyzer (1) when the transmembrane pressure exceeds a predetermined level. Reverse filtering is performed by flushing operation and clogging of pores of the dialyzing membrane in the dialyzer (1) is eliminated thus recovering performance of the dialyzer (1).

摘要翻译： 本发明提供一种血液透析器，能够在透析期间精确地掌握中空纤维的膜性能劣化，能够迅速而正确地回收。 将具有血液泵（7）的动脉侧血液回路（2）与透析器（1）的动脉侧连接的血液透析器，将静脉侧血液回路（3）连接到透析器（1）的静脉侧 ）和将透析液供给管线（4）和透析液排出管线（5）分别连接到透析器（1）的侧面，设置有用于确定血液回路中的压力的​​检测器（15） 以及用于确定透析液线中的压力的​​检测器（16），其中基于所确定的压力计算跨膜压力，并且当跨膜压力超过预定水平时，由透析器（1）进行反向过滤。 通过冲洗操作进行反向过滤，消除透析器（1）中透析膜孔的堵塞，从而恢复透析器（1）的性能。