公开(公告)号：EP1694641A2

公开(公告)日：2006-08-30

申请号：EP04801246.2

申请日：2004-12-01

申请人： JOHNSON MATTHEY PUBLIC LIMITED COMPANY

发明人： CLISSOLD, Derek Wyndham ,  CRAIG, Stuart Wilbert ,  GADIKOTA, Rajendrakumar, Reddy ,  HE, Min ,  JURAYJ, Jurjus Fayez ,  KAZERANI, Shahrokh ,  RANNALA, Erwin ,  SHARMA, Pradeep, Kumar

IPC分类号： C07C405/00 ,  C07D309/12

CPC分类号： C07D307/935 ,  C07C405/00 ,  C07C405/0016 ,  C07D309/12 ,  C07D407/12 ,  Y02P20/55

摘要： A process for the preparation of prostaglandin compounds having the formula (I); wherein A is selected from the group consisting Of C1-C6 alkyl; C7-C16 aralkyl wherein the aryl group is optionally substituted with one to three substituents selected from the group consisting Of C1 -C6 alkyl, halo and CF3; and (CH2)nOR' wherein n is from 1 to 3 and R' represents a C6-Cl0 aryl group which is optionally substituted with one to three substituents selected from the group consisting Of C1-C6 alkyl, halo and CF3; B is selected from OR' and NHR' wherein R' is C1-C6 alkyl; and formula (a) represents a double bond or a single bond, is disclosed. Novel intermediates are also disclosed.

公开(公告)号：EP1694641B1

公开(公告)日：2009-04-15

申请号：EP04801246.2

申请日：2004-12-01

申请人： JOHNSON MATTHEY PUBLIC LIMITED COMPANY

发明人： CLISSOLD, Derek Wyndham ,  CRAIG, Stuart Wilbert ,  GADIKOTA, Rajendrakumar, Reddy ,  HE, Min ,  JURAYJ, Jurjus Fayez ,  KAZERANI, Shahrokh ,  RANNALA, Erwin ,  SHARMA, Pradeep, Kumar

IPC分类号： C07C405/00 ,  C07D309/12

CPC分类号： C07D307/935 ,  C07C405/00 ,  C07C405/0016 ,  C07D309/12 ,  C07D407/12 ,  Y02P20/55

摘要： A process for the preparation of prostaglandin compounds having the formula (I); wherein A is selected from the group consisting Of C1-C6 alkyl; C7-C16 aralkyl wherein the aryl group is optionally substituted with one to three substituents selected from the group consisting Of C1 -C6 alkyl, halo and CF3; and (CH2)nOR' wherein n is from 1 to 3 and R' represents a C6-Cl0 aryl group which is optionally substituted with one to three substituents selected from the group consisting Of C1-C6 alkyl, halo and CF3; B is selected from OR' and NHR' wherein R' is C1-C6 alkyl; and formula (a) represents a double bond or a single bond, is disclosed. Novel intermediates are also disclosed.