公开(公告)号：EP1118660A4

公开(公告)日：2003-04-23

申请号：EP99970118

申请日：1999-09-29

申请人： JURIDICAL FOUNDATION

发明人： MORIKAWA WATARU ,  KAMINAKA KAZUYOSHI-GADENKOTO-M ,  TAKEMOTO SUMIYO ,  MAEDA HIROAKI ,  NOZAKI CHIKATERU ,  MIYAMOTO SEIJI

IPC分类号： C12N15/09 ,  A61K31/00 ,  A61K35/00 ,  A61K38/00 ,  A61K38/46 ,  A61P27/00 ,  A61P27/02 ,  A61P35/00 ,  A61P35/04 ,  A61P43/00 ,  C07K14/52 ,  C07K14/745 ,  C12N9/64 ,  C12N9/68 ,  C12N15/00 ,  A61K38/48 ,  C07K1/22 ,  C07K14/78 ,  C12N9/50

CPC分类号： C12N9/6454 ,  A61K35/00 ,  C12N9/6435 ,  C12N9/6478 ,  C12Y304/21007

摘要： An aspartic acid enzyme having a high homology with a cathepsin D precursor, which is a protein starting at the N-terminal amino acid residue with LVRIPLHKFT and showing a molecular weight of about 45 kDa in non-reductive SDS electrophoresis and can degrade plasma proteins typified by plasminogen molecular species to give a plasma protein fragment having an effect of inhibiting cancer metastasis; the plasma protein fragment having an effect of inhibiting cancer metastasis which is prepared via the degradation with the above enzyme; a process for preparing the protein fragment having an effect of inhibiting cancer metastasis which comprises degrading a plasma protein with the above enzyme; and remedies against cancer metastasis which contain as the major ingredient the above enzyme or a fragmented plasma protein.