公开(公告)号：EP0914830A4

公开(公告)日：2002-03-20

申请号：EP97907445

申请日：1997-03-24

申请人： JURIDICAL FOUNDATION

发明人： HAMURO TSUTORNU ,  NAKAHARA YO ,  TAKEMOTO SUMIYO ,  MIYAMOTO SEIJI

IPC分类号： A61K38/57 ,  A61P35/00 ,  A61K38/55

CPC分类号： A61K38/57 ,  Y10S514/885 ,  Y10S514/886 ,  Y10S514/914

摘要： An inhibitor for neovascularization caused by the proliferation of vascular endothelial cells characterized by containing a tissue factor pathway inhibitor (TFPI) as the active ingredient. The TFPI-containing inhibitor can effectively inhibit the neovascularization, so that it is useful as a preventive or remedy for pathological conditions accompanying neovascularization, such as malignant tumor.

公开(公告)号：EP0867450A4

公开(公告)日：2000-01-19

申请号：EP96935411

申请日：1996-10-23

申请人： JURIDICAL FOUNDATION

发明人： NAKAHARA YO ,  HARA SABURO ,  KAMIKUBO YUICHI ,  TAKEMOTO SUMIYO ,  MIYAMOTO SEIJI

IPC分类号： A61K38/00 ,  C07K7/06 ,  C07K7/08 ,  C07K14/47 ,  C07K14/745 ,  C07K14/81 ,  C07K19/00 ,  A61K38/36

CPC分类号： C07K7/06 ,  A61K38/00 ,  C07K7/08 ,  C07K14/47 ,  C07K14/745 ,  C07K14/8114 ,  C07K19/00 ,  C07K2319/00

摘要： A peptide comprising a peptide (A) of an amino acid sequence being abundant in basic amino acid residues and a peptide (B) of an amino acid sequence comprising at least two consecutive, hydrophobic amino acid residues wherein the peptide (B) is linked to the C-terminal of the peptide (A) directly or via several amino acid residues. The novel peptide of the present invention has the activity to inhibit growth of smooth muscle cells and a pharmaceutical composition comprising said peptide is useful for preventing or treating pathological conditions associated with growth of smooth muscle cells such as arteriosclerosis, restenosis after angioplasty, luminal stenosis after grafting blood vessel and smooth muscle sarcoma.

公开(公告)号：EP1118660A4

公开(公告)日：2003-04-23

申请号：EP99970118

申请日：1999-09-29

申请人： JURIDICAL FOUNDATION

发明人： MORIKAWA WATARU ,  KAMINAKA KAZUYOSHI-GADENKOTO-M ,  TAKEMOTO SUMIYO ,  MAEDA HIROAKI ,  NOZAKI CHIKATERU ,  MIYAMOTO SEIJI

IPC分类号： C12N15/09 ,  A61K31/00 ,  A61K35/00 ,  A61K38/00 ,  A61K38/46 ,  A61P27/00 ,  A61P27/02 ,  A61P35/00 ,  A61P35/04 ,  A61P43/00 ,  C07K14/52 ,  C07K14/745 ,  C12N9/64 ,  C12N9/68 ,  C12N15/00 ,  A61K38/48 ,  C07K1/22 ,  C07K14/78 ,  C12N9/50

CPC分类号： C12N9/6454 ,  A61K35/00 ,  C12N9/6435 ,  C12N9/6478 ,  C12Y304/21007

摘要： An aspartic acid enzyme having a high homology with a cathepsin D precursor, which is a protein starting at the N-terminal amino acid residue with LVRIPLHKFT and showing a molecular weight of about 45 kDa in non-reductive SDS electrophoresis and can degrade plasma proteins typified by plasminogen molecular species to give a plasma protein fragment having an effect of inhibiting cancer metastasis; the plasma protein fragment having an effect of inhibiting cancer metastasis which is prepared via the degradation with the above enzyme; a process for preparing the protein fragment having an effect of inhibiting cancer metastasis which comprises degrading a plasma protein with the above enzyme; and remedies against cancer metastasis which contain as the major ingredient the above enzyme or a fragmented plasma protein.