公开(公告)号：EP0914830A4

公开(公告)日：2002-03-20

申请号：EP97907445

申请日：1997-03-24

申请人： JURIDICAL FOUNDATION

发明人： HAMURO TSUTORNU ,  NAKAHARA YO ,  TAKEMOTO SUMIYO ,  MIYAMOTO SEIJI

IPC分类号： A61K38/57 ,  A61P35/00 ,  A61K38/55

CPC分类号： A61K38/57 ,  Y10S514/885 ,  Y10S514/886 ,  Y10S514/914

摘要： An inhibitor for neovascularization caused by the proliferation of vascular endothelial cells characterized by containing a tissue factor pathway inhibitor (TFPI) as the active ingredient. The TFPI-containing inhibitor can effectively inhibit the neovascularization, so that it is useful as a preventive or remedy for pathological conditions accompanying neovascularization, such as malignant tumor.

公开(公告)号：EP0867450A4

公开(公告)日：2000-01-19

申请号：EP96935411

申请日：1996-10-23

申请人： JURIDICAL FOUNDATION

发明人： NAKAHARA YO ,  HARA SABURO ,  KAMIKUBO YUICHI ,  TAKEMOTO SUMIYO ,  MIYAMOTO SEIJI

IPC分类号： A61K38/00 ,  C07K7/06 ,  C07K7/08 ,  C07K14/47 ,  C07K14/745 ,  C07K14/81 ,  C07K19/00 ,  A61K38/36

CPC分类号： C07K7/06 ,  A61K38/00 ,  C07K7/08 ,  C07K14/47 ,  C07K14/745 ,  C07K14/8114 ,  C07K19/00 ,  C07K2319/00

摘要： A peptide comprising a peptide (A) of an amino acid sequence being abundant in basic amino acid residues and a peptide (B) of an amino acid sequence comprising at least two consecutive, hydrophobic amino acid residues wherein the peptide (B) is linked to the C-terminal of the peptide (A) directly or via several amino acid residues. The novel peptide of the present invention has the activity to inhibit growth of smooth muscle cells and a pharmaceutical composition comprising said peptide is useful for preventing or treating pathological conditions associated with growth of smooth muscle cells such as arteriosclerosis, restenosis after angioplasty, luminal stenosis after grafting blood vessel and smooth muscle sarcoma.