公开(公告)号：EP3405493A1

公开(公告)日：2018-11-28

申请号：EP17702264.7

申请日：2017-01-19

申请人： Janssen Biotech, Inc.

发明人： ANDERSON, Glenn Mark ,  ATTAR, Ricardo ,  BALDWIN, Eric T. ,  CARDOSO, Rosa M.F. ,  GAUDET, Francois ,  HARMAN, Benjamin ,  LI, Yingzhe ,  LUO, Jinquan ,  MCDAID, Ronan ,  NEMETH-SEAY, Jennifer F. ,  POMERANTZ, Steven C. ,  TEPLYAKOV, Alexey ,  TAM, Susan H. ,  WU, Sheng-Jiun

IPC分类号： C07K16/28 ,  A61P35/00 ,  A61K39/395

CPC分类号： C07K16/28 ,  A61K2039/505 ,  C07K16/2803 ,  C07K16/2809 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/92

摘要： Provided herein are isolated antibodies that immunospecifically bind to ROR1, bispecific antibodies comprising an antigen-binding site that immunospecifically binds to ROR1 and an antigen-binding site that immunospecifically binds to CD3, and methods of using the same.