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公开(公告)号：EP3911677A1
公开(公告)日：2021-11-24
申请号：EP20701897.9
申请日：2020-01-15
发明人： ATTAR, Ricardo , GANESAN, Rajkumar , GAUDET, Francois , HEIDRICH, Bradley J. , JONES, Carmen Baca , LEE, John , LI, Yingzhe , SINGH, Sanjaya , VENKATARAMANI, Sathya
IPC分类号： C07K16/28 , A61P35/00 , C07K14/725 , A61K35/17 , A61K39/00
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公开(公告)号：EP3793606A2
公开(公告)日：2021-03-24
申请号：EP19803950.5
申请日：2019-05-15
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3.发明公开
公开(公告)号：EP4153317A1
公开(公告)日：2023-03-29
申请号：EP21727576.7
申请日：2021-05-18
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公开(公告)号：EP3802606A2
公开(公告)日：2021-04-14
申请号：EP19737216.2
申请日：2019-05-21
IPC分类号： C07K16/28 , A61K39/395 , A61P35/02
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5.发明公开PROSTATE SPECIFIC MEMBRANE ANTIGEN (PSMA) BISPECIFIC BINDING AGENTS AND USES THEREOF 审中-公开前列腺特异性膜抗原（PSMA）双特异性结合剂及其用途
公开(公告)号：EP3291836A2
公开(公告)日：2018-03-14
申请号：EP16790175.0
申请日：2016-05-06
发明人： ANDERSON, Glenn , CARDOSO, Rosa , DIEM, Michael , GAUDET, Francois , GOLDBERG, Shalom , HARMAN, Benjamin C. , HYUN, Linus , JACOBS, Steven , KLEIN, Donna , LI, Yingzhe , LUO, Jinquan , MCDAID, Ronan , NEMETH-SEAY, Jennifer , O'NEIL, Karyn , POMERANTZ, Steven C. , CHANDRA RAO, Galla , SPINKA-DOMS, Tracy , TEPLYAKOV, Alexey , WU, Sheng-Jiun , MOONEY, Jill , LUISTRO, Leopoldo
IPC分类号： A61K39/395 , A61P35/00 , C07K16/00 , C07K16/28
CPC分类号： C07K16/2809 , A61K45/06 , A61K47/6803 , A61K47/6869 , A61K49/0045 , A61K49/0058 , A61K2039/505 , C07K14/78 , C07K16/3069 , C07K2317/24 , C07K2317/31 , C07K2317/524 , C07K2317/53 , C07K2317/55 , C07K2317/70 , C07K2317/73 , C07K2317/92 , C07K2317/94 , C07K2318/20 , C07K2319/30 , C12Y304/17021
摘要： Provided herein are isolated CD3×PSMA-bispecific antigen-binding molecules or bispecific antigen-binding fragment thereof wherein a FN3 domain specifically binds human prostate specific membrane antigen (PSMA) and a second antigen-binding site immunospecifically binds CD3. Also described are fusion proteins and related polynucleotides capable of encoding the provided fusion proteins and, cells expressing the provided fusion proteins. In addition, methods of using the provided isolated CD3×PSMA-bispecific antigen-binding molecules or bispecific antigen-binding fragment thereof are described.
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公开(公告)号：EP4340942A1
公开(公告)日：2024-03-27
申请号：EP22726817.4
申请日：2022-05-16
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公开(公告)号：EP3802608A2
公开(公告)日：2021-04-14
申请号：EP19737219.6
申请日：2019-05-21
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公开(公告)号：EP3793599A1
公开(公告)日：2021-03-24
申请号：EP19739378.8
申请日：2019-05-15
IPC分类号： A61K39/395 , A61K45/06 , C07K16/28 , C07K16/30 , A61K39/00
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公开(公告)号：EP3405493A1
公开(公告)日：2018-11-28
申请号：EP17702264.7
申请日：2017-01-19
发明人： ANDERSON, Glenn Mark , ATTAR, Ricardo , BALDWIN, Eric T. , CARDOSO, Rosa M.F. , GAUDET, Francois , HARMAN, Benjamin , LI, Yingzhe , LUO, Jinquan , MCDAID, Ronan , NEMETH-SEAY, Jennifer F. , POMERANTZ, Steven C. , TEPLYAKOV, Alexey , TAM, Susan H. , WU, Sheng-Jiun
IPC分类号： C07K16/28 , A61P35/00 , A61K39/395
CPC分类号： C07K16/28 , A61K2039/505 , C07K16/2803 , C07K16/2809 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/565 , C07K2317/73 , C07K2317/92
摘要： Provided herein are isolated antibodies that immunospecifically bind to ROR1, bispecific antibodies comprising an antigen-binding site that immunospecifically binds to ROR1 and an antigen-binding site that immunospecifically binds to CD3, and methods of using the same.
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