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公开(公告)号：EP3485901A1
公开(公告)日：2019-05-22
申请号：EP18197990.7
申请日：2013-11-21
发明人： ANDERSON, Mark , ATTAR, Ricardo , DIEM, Michael , HYUN, Linus , JACOBS, Steven , KING, Alastair , KLEIN, Donna , MOORES, Sheri , O'NEIL, Karyn , PICHA, Kristen
摘要： Monospecific and bispecific EGFR and/or c-Met FN3 domain containing molecules, isolated nucleotides encoding the molecules, vectors, host cells, and methods of making thereof are useful in the generation of therapeutic molecules and treatment and diagnosis of diseases and disorders.
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公开(公告)号：EP4061405A1
公开(公告)日：2022-09-28
申请号：EP20811745.7
申请日：2020-11-13
发明人： ATTAR, Ricardo , DEHART, Jason , KHAN, Selina , KRISHNA, Vinod , LUM, Jenifer , MAINE, Christian , SANDERS, Barbara , SEPULVEDA, Manuel Alejandro , WILKINSON, Patrick , ZAHN, Roland
IPC分类号： A61K39/00 , A61K39/395 , C07K16/28 , C12N15/62 , C12N15/861 , C12N15/863 , A61P35/00
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公开(公告)号：EP4023670A1
公开(公告)日：2022-07-06
申请号：EP21201889.9
申请日：2013-11-21
发明人： ANDERSON, Mark , ATTAR, Ricardo , DIEM, Michael , HYUN, Linus , JACOBS, Steven , KING, Alastair , KLEIN, Donna , MOORES, Sheri , O'NEIL, Karyn , PICHA, Kristen
IPC分类号： C07K16/00 , A61K39/395 , A61K31/4545 , A61K31/517 , A61K45/06 , A61K31/437 , A61K31/5377 , A61K33/24 , C07K16/28 , A61P35/00 , C07K14/47 , C07K14/705 , C07K14/71 , C07K14/78
摘要： Monospecific and bispecific EGFR and/or c-Met FN3 domain containing molecules, isolated nucleotides encoding the molecules, vectors, host cells, and methods of making thereof are useful in the generation of therapeutic molecules and treatment and diagnosis of diseases and disorders.
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公开(公告)号：EP3405493A1
公开(公告)日：2018-11-28
申请号：EP17702264.7
申请日：2017-01-19
发明人： ANDERSON, Glenn Mark , ATTAR, Ricardo , BALDWIN, Eric T. , CARDOSO, Rosa M.F. , GAUDET, Francois , HARMAN, Benjamin , LI, Yingzhe , LUO, Jinquan , MCDAID, Ronan , NEMETH-SEAY, Jennifer F. , POMERANTZ, Steven C. , TEPLYAKOV, Alexey , TAM, Susan H. , WU, Sheng-Jiun
IPC分类号： C07K16/28 , A61P35/00 , A61K39/395
CPC分类号： C07K16/28 , A61K2039/505 , C07K16/2803 , C07K16/2809 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/565 , C07K2317/73 , C07K2317/92
摘要： Provided herein are isolated antibodies that immunospecifically bind to ROR1, bispecific antibodies comprising an antigen-binding site that immunospecifically binds to ROR1 and an antigen-binding site that immunospecifically binds to CD3, and methods of using the same.
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公开(公告)号：EP3471750A2
公开(公告)日：2019-04-24
申请号：EP17816128.7
申请日：2017-06-21
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公开(公告)号：EP3154581A1
公开(公告)日：2017-04-19
申请号：EP15747597.1
申请日：2015-06-15
申请人： The United States Of America, As Represented By The Secretary, Department Of Health And Human Services , Janssen Biotech, Inc.
IPC分类号： A61K39/395 , C07K16/28 , A61P35/00 , A61P37/00
CPC分类号： C07K16/2896 , A61K39/39558 , A61P35/02 , A61P37/00 , C07K2317/21 , C07K2317/54 , C07K2317/73 , C07K2317/732 , A61K2300/00
摘要： Provided herein are methods of inhibiting growth or proliferation of cells expressing CD38 by contacting the CD38-expressing cells with 1) NK cells bound to an anti-CD38 F(ab′)2 fragment and 2) an anti-CD38 antibody, in either order or simultaneously. Also provided herein are methods of treating or inhibiting a hyperproliferative disorder or an autoimmune disorder in a subject by administering to the subject 1) NK cells bound to an anti-CD38 F(ab′)2 fragment and 2) an anti-CD38 antibody, in either order or simultaneously.
摘要翻译： 本文提供了通过使表达CD38的细胞与1）结合抗CD38F（ab'）2片段的NK细胞和2）抗CD38抗体以任何顺序接触来抑制表达CD38的细胞的生长或增殖的方法 或同时进行。 本文还提供了通过向受试者施用1）与抗CD38F（ab'）2片段结合的NK细胞和2）抗CD38抗体治疗或抑制受试者过度增殖性病症或自身免疫病症的方法， 以任何顺序或同时进行。
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公开(公告)号：EP3911677A1
公开(公告)日：2021-11-24
申请号：EP20701897.9
申请日：2020-01-15
发明人： ATTAR, Ricardo , GANESAN, Rajkumar , GAUDET, Francois , HEIDRICH, Bradley J. , JONES, Carmen Baca , LEE, John , LI, Yingzhe , SINGH, Sanjaya , VENKATARAMANI, Sathya
IPC分类号： C07K16/28 , A61P35/00 , C07K14/725 , A61K35/17 , A61K39/00
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公开(公告)号：EP3154581B1
公开(公告)日：2019-02-20
申请号：EP15747597.1
申请日：2015-06-15
申请人： The United States Of America, As Represented By The Secretary, Department Of Health And Human Services , Janssen Biotech, Inc.
IPC分类号： A61K39/395 , C07K16/28 , A61P35/00 , A61P37/00
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公开(公告)号：EP2922566B1
公开(公告)日：2018-10-03
申请号：EP13856353.1
申请日：2013-11-21
发明人： ANDERSON, Mark , ATTAR, Ricardo , DIEM, Michael , HYUN, Linus , JACOBS, Steven , KING, Alastair , KLEIN, Donna , MOORES, Sheri , O'NEIL, Karyn , PICHA, Kristen
CPC分类号： C07K14/78 , A61K38/00 , A61K45/06 , A61K2039/505 , C07K14/47 , C07K14/705 , C07K14/71 , C07K16/28 , C07K16/2863 , C07K2317/31 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2318/20 , C07K2319/70
摘要： Monospecific and bispecific EGFR and/or c-Met FN3 domain containing molecules, isolated nucleotides encoding the molecules, vectors, host cells, and methods of making thereof are useful in the generation of therapeutic molecules and treatment and diagnosis of diseases and disorders.
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公开(公告)号：EP2922566A2
公开(公告)日：2015-09-30
申请号：EP13856353.1
申请日：2013-11-21
发明人： ANDERSON, Mark , ATTAR, Ricardo , DIEM, Michael , HYUN, Linus , JACOBS, Steven , KING, Alastair , KLEIN, Donna , MOORES, Sheri , O'NEIL, Karyn , PICHA, Kristen
CPC分类号： C07K14/78 , A61K38/00 , A61K45/06 , A61K2039/505 , C07K14/47 , C07K14/705 , C07K14/71 , C07K16/28 , C07K16/2863 , C07K2317/31 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2318/20 , C07K2319/70
摘要： Monospecific and bispecific EGFR and/or c-Met FN3 domain containing molecules, isolated nucleotides encoding the molecules, vectors, host cells, and methods of making thereof are useful in the generation of therapeutic molecules and treatment and diagnosis of diseases and disorders.
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